{"id":55969,"date":"2023-04-18T21:03:28","date_gmt":"2023-04-18T19:03:28","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/palleon-pharmaceuticals-presents-initial-phase-1-results-from-the-glimmer-01-clinical-trial-for-e-602-the-first-ever-glyco-immune-checkpoint-inhibitor\/"},"modified":"2023-04-18T21:03:28","modified_gmt":"2023-04-18T19:03:28","slug":"palleon-pharmaceuticals-presents-initial-phase-1-results-from-the-glimmer-01-clinical-trial-for-e-602-the-first-ever-glyco-immune-checkpoint-inhibitor","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/palleon-pharmaceuticals-presents-initial-phase-1-results-from-the-glimmer-01-clinical-trial-for-e-602-the-first-ever-glyco-immune-checkpoint-inhibitor\/","title":{"rendered":"Palleon Pharmaceuticals Presents Initial Phase 1 Results from the GLIMMER-01 Clinical Trial for E-602, the First Ever Glyco-Immune Checkpoint Inhibitor"},"content":{"rendered":"
\n

\n– Proof of mechanism for novel glyco-immune checkpoint inhibitor established with evidence of dose dependent desialylation and immune system activation <\/i>–<\/p>\n

\n– E-602 was well-tolerated across the entire dose range with no dose-limiting toxicities –<\/i><\/p>\n

\n– Palleon to proceed with Phase 2 evaluation –<\/i><\/p>\n

WALTHAM, Mass.–(BUSINESS WIRE)–Palleon Pharmaceuticals<\/a>, a clinical-stage company pioneering glyco-immunology drug development to treat cancer and inflammatory diseases, today announced the initial Phase 1 results from the GLIMMER-01 trial of its lead EAGLE oncology platform program, E-602, at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, Florida.<\/p>\n

<\/a><\/p>\n

\nThe study demonstrated proof of mechanism for E-602, a first-in-class glyco-immune checkpoint inhibitor, including dose dependent desialylation and dose dependent immune system activation. Additionally, E-602 was found to be well tolerated across the entire dose range evaluated with no dose limiting toxicities. Having met pre-specified gating criteria based on safety and pharmacodynamic activity, Palleon announced plans to proceed with Phase 2 evaluation.<\/p>\n

\n\u201cE-602 represents a truly novel immuno-oncology candidate that builds on the promise of glycobiology, a field of study that offers unprecedented opportunities for drug development in cancer and other diseases,\u201d said David Feltquate, M.D., Ph.D., Chief Medical Officer of Palleon Pharmaceuticals. \u201cEstablishing proof of mechanism for this approach provides the validation necessary to initiate Phase 2 evaluation and take next steps towards our team\u2019s shared goal of offering new options for patients in need.\u201d<\/p>\n

\n\u201cIt is exciting to see the first clinical results generated from Palleon\u2019s EAGLE glyco-immunology drug development platform,\u201d said Carolyn Bertozzi, Ph.D., Palleon Scientific Co-Founder and 2022 Nobel laureate. \u201cPalleon is advancing an entirely new axis of immune modulation, defined by the interaction between sialoglycans and their receptors, which may benefit patients who do not respond to current medications.\u201d<\/p>\n

\nIn the initial results from the GLIMMER-01 trial presented by lead investigator, Jason Luke, M.D., of UPMC Hillman Cancer Center, 40 patients were treated with at least one dose of E-602, the most common tumors treated being colorectal (n=21) and pancreatic (n=10). Doses up to 30 mg\/kg were tolerated with no dose-limiting toxicities. Both dose-dependent desialylation and immune system activation, as measured by increases in activated (CD69+) immune cells in circulation and elevation of circulating cytokines and chemokines including IP-10\/CXCL10, were observed. Phase 2 studies will evaluate clinical activity of E-602 monotherapy in patients with lung cancer and melanoma.<\/p>\n

\nThe presentation can be found in the Palleon Publications section of the Education Hub page of our website.<\/p>\n

\nAbout Palleon Pharmaceuticals<\/b><\/p>\n

\nPalleon Pharmaceuticals, co-founded by Nobel laureate Carolyn Bertozzi, is a biotechnology company pioneering glyco-immunology drug development to transform the treatment of cancer and inflammatory diseases. The Company\u2019s proprietary platforms overcome technical barriers unique to glycobiology to enable drug discovery, patient selection, and indication prioritization to de-risk clinical development. The company\u2019s lead program in oncology, E-602, is a first-in-class, glyco-immune checkpoint inhibitor which restores antitumor immunity by enzymatically degrading immunosuppressive sialoglycans on hypersialylated tumors and immune cells. It is being evaluated in a Phase 1\/2 clinical trial. Palleon has a rich pipeline of additional drug candidates including several advancing toward IND-enabling studies.<\/p>\n

Contacts<\/b> <\/p>\n

\nMedia Contact<\/b>
Thomas Stephenson
\n
Ten Bridge Communications
\n
thomas@tenbridgecommunications.com<\/a>
(857) 244-0246<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

– Proof of mechanism for novel glyco-immune checkpoint inhibitor established with evidence of dose dependent desialylation and immune system activation – – E-602 was well-tolerated across the entire dose range with no dose-limiting toxicities – – Palleon to proceed with Phase 2 evaluation – WALTHAM, Mass.–(BUSINESS WIRE)–Palleon Pharmaceuticals, a clinical-stage company pioneering glyco-immunology drug development … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-55969","6":"format-standard","7":"category-industry"},"yoast_head":"\nPalleon Pharmaceuticals Presents Initial Phase 1 Results from the GLIMMER-01 Clinical Trial for E-602, the First Ever Glyco-Immune Checkpoint Inhibitor - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/palleon-pharmaceuticals-presents-initial-phase-1-results-from-the-glimmer-01-clinical-trial-for-e-602-the-first-ever-glyco-immune-checkpoint-inhibitor\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Palleon Pharmaceuticals Presents Initial Phase 1 Results from the GLIMMER-01 Clinical Trial for E-602, the First Ever Glyco-Immune Checkpoint Inhibitor - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"– Proof of mechanism for novel glyco-immune checkpoint inhibitor established with evidence of dose dependent desialylation and immune system activation – – E-602 was well-tolerated across the entire dose range with no dose-limiting toxicities – – Palleon to proceed with Phase 2 evaluation – WALTHAM, Mass.–(BUSINESS WIRE)–Palleon Pharmaceuticals, a clinical-stage company pioneering glyco-immunology drug development ... 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