{"id":56061,"date":"2023-04-20T18:04:37","date_gmt":"2023-04-20T16:04:37","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/poxel-announces-multiple-twymeeg-imeglimin-abstracts-accepted-for-oral-presentation\/"},"modified":"2023-04-20T18:04:37","modified_gmt":"2023-04-20T16:04:37","slug":"poxel-announces-multiple-twymeeg-imeglimin-abstracts-accepted-for-oral-presentation","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/poxel-announces-multiple-twymeeg-imeglimin-abstracts-accepted-for-oral-presentation\/","title":{"rendered":"Poxel Announces Multiple TWYMEEG\u00ae (Imeglimin) Abstracts Accepted for Oral Presentation"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<b>Nine Imeglimin abstracts to be presented at the 66<sup>th<\/sup> Annual Meeting of the Japanese Diabetes Society<\/b><\/li>\n<\/ul>\n<p>LYON, France&#8211;(BUSINESS WIRE)&#8211;Regulatory News:<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20230420005715\/en\/729490\/5\/POXEL_LOGO_Q.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20230420005715\/en\/729490\/21\/POXEL_LOGO_Q.jpg\"><\/a><\/p>\n<p>\n<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.poxel.com%2F&amp;esheet=53384820&amp;newsitemid=20230420005715&amp;lan=en-US&amp;anchor=POXEL+SA&amp;index=1&amp;md5=bde1c11690f61675349db3bfbfc40e70\" rel=\"nofollow noopener\" shape=\"rect\">POXEL SA<\/a> (Euronext: POXEL &#8211; FR0012432516) (Paris:POXEL), a clinical stage biopharmaceutical company developing innovative treatments for serious chronic diseases with metabolic pathophysiology, including non-alcoholic steatohepatitis (NASH) and rare metabolic disorders, announced today that nine abstracts based on Imeglimin Phase 2b and Phase 3 clinical trials have been accepted for oral presentations at the 66<sup>th<\/sup> Annual Meeting of the Japanese Diabetes Society (JDS), held in Kagoshima, Japan, May 11-13, 2023.<\/p>\n<p>\nPartnered in Japan with the diabetes market leader, Sumitomo Pharma (Sumitomo), TWYMEEG is Poxel\u2019s first commercialized product. Launched in 2021, sales have demonstrated a strong growth trajectory in recent months that led Sumitomo to increase its full year 2022 forecast<sup>1<\/sup>. Sumitomo is continuing to strengthen TWYMEEG\u2019s therapeutic profile, specifically exploring its potential benefits in Type-2-diabetes mellitus patients with chronic kidney disease with an open-label, multi-center Phase 4 study. The objective of this study is to assess the safety, efficacy and pharmacokinetics of TWYMEEG in Japanese type 2 diabetes patients with renal impairment.<\/p>\n<p>\nThe abstracts accepted for oral presentation<sup>2<\/sup> at the upcoming JDS are:<\/p>\n<ol class=\"bwlistdecimal\">\n<li>\nAnalysis of early responders to Imeglimin monotherapy:<br \/>\n<br \/>a post-hoc analysis of clinical trial data in Japanese patients with Type-2-diabetes mellitus<\/li>\n<li>\nTime analysis of treatment response and treatment failure to Imeglimin treatment:<br \/>\n<br \/>a post-hoc analysis of a study of Imeglimin monotherapy in Japanese patients with Type-2-diabetes mellitus<\/li>\n<li>\nCharacterization of responders to Imeglimin treatment:<br \/>\n<br \/>a post-hoc analysis of a study of Imeglimin add-on to insulin monotherapy in Japanese patients with Type-2-diabetes mellitus<\/li>\n<li>\nEfficacy and safety of Imeglimin by concomitant insulin type:<br \/>\n<br \/>a post-hoc analysis of a study of Imeglimin add-on to insulin therapy in patients with Type-2-diabetes mellitus<\/li>\n<li>\nEfficacy and safety of Imeglimin in Japanese patients with history of recent Type-2-diabetes mellitus: A post-hoc analysis of the Imeglimin monotherapy study<\/li>\n<li>\nEfficacy and safety of imeglimin in patients with and without drinking habit:<br \/>\n<br \/>a post-hoc analysis of a clinical study of Imeglimin in Japanese patients with Type-2-diabetes mellitus<\/li>\n<li>\nEfficacy and safety of Imeglimin in patients with and without smoking habit:<br \/>\n<br \/>a post-hoc analysis of a clinical trial of Imeglimin in Japanese patients with Type-2-diabetes mellitus<\/li>\n<li>\nAntihyperglycemic effect of Imeglimin monotherapy: an analysis of response trajectories using time series cluster analysis<\/li>\n<li>\nEffect of Imeglimin monotherapy on HOMA-\u03b2: a post-hoc analysis of a clinical study of Imeglimin in Japanese patients with type 2 diabetes mellitus.<\/li>\n<\/ol>\n<p>\nImeglimin is partnered with Sumitomo Pharma in Japan, and 12 other Asian countries<sup>3<\/sup>. Poxel is also considering potential additional partnerships in specific territories.<\/p>\n<p>\n<b>About Poxel SA<\/b><\/p>\n<p>\nPoxel is a <b>clinical stage biopharmaceutical company<\/b> developing <b>innovative treatments for chronic serious diseases with metabolic pathophysiology<\/b>, including <b>non-alcoholic steatohepatitis (NASH)<\/b> and rare disorders. For the treatment of NASH, <b>PXL065<\/b> (deuterium-stabilized <i>R<\/i>-pioglitazone) met its primary endpoint in a streamlined Phase 2 trial (DESTINY-1). In rare diseases, development of <b>PXL770<\/b>, a first-in-class direct adenosine monophosphate-activated protein kinase (AMPK) activator, is focused on the treatment of adrenoleukodystrophy (ALD) and autosomal dominant polycystic kidney disease (ADPKD). <b>TWYMEEG<sup>\u00ae<\/sup><\/b> (Imeglimin), Poxel\u2019s first-in-class product that targets mitochondrial dysfunction, is marketed for the treatment of type 2 diabetes in Japan by Sumitomo Pharma and Poxel expects to receive royalties and sales-based payments. Poxel has a strategic partnership with Sumitomo Pharma for Imeglimin in Japan, China, and eleven other Asian countries. Listed on Euronext Paris, Poxel is headquartered in Lyon, France, and has subsidiaries in Boston, MA, and Tokyo, Japan.<\/p>\n<p>\nFor more information, please visit: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.poxelpharma.com&amp;esheet=53384820&amp;newsitemid=20230420005715&amp;lan=en-US&amp;anchor=www.poxelpharma.com&amp;index=2&amp;md5=79c60f49687d72a8d8f796447fe338f1\" rel=\"nofollow noopener\" shape=\"rect\">www.poxelpharma.com<\/a><\/p>\n<p>\nAll statements other than statements of historical fact included in this press release about future events are subject to (i) change without notice and (ii) factors beyond the Company\u2019s control. These statements may include, without limitation, any statements preceded by, followed by or including words such as \u201ctarget,\u201d \u201cbelieve,\u201d \u201cexpect,\u201d \u201caim,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201canticipate,\u201d \u201cestimate,\u201d \u201cplan,\u201d \u201cproject,\u201d \u201cwill,\u201d \u201ccan have,\u201d \u201clikely,\u201d \u201cshould,\u201d \u201cwould,\u201d \u201ccould\u201d and other words and terms of similar meaning or the negative thereof. Forward-looking statements are subject to inherent risks and uncertainties beyond the Company\u2019s control that could cause the Company\u2019s actual results or performance to be materially different from the expected results or performance expressed or implied by such forward-looking statements. The Company does not endorse or is not otherwise responsible for the content of external hyperlinks referred to in this press release.<\/p>\n<p>\n&#8212;&#8212;&#8212;&#8211;<\/p>\n<p>\n<sup>1<\/sup> Sumitomo\u2019s fiscal year ends 0n March 31 2023.<br \/>\n<br \/><sup>2<\/sup> Official titles of presentations translated from original Japanese.<br \/>\n<br \/><sup>3<\/sup> Includes: China, South Korea, Taiwan, Indonesia, Vietnam, Thailand, Malaysia, Philippines, Singapore, Myanmar, Cambodia, Laos<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Contacts &#8211; Investor relations \/ Media<\/b><br \/>Aur\u00e9lie Bozza<br \/>\n<br \/>Investor Relations &amp; Communication Senior Director<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#97;&#x69;l&#116;&#x6f;&#x3a;a&#117;&#x72;&#x65;l&#105;&#x65;&#x2e;b&#111;&#x7a;&#x7a;a&#64;&#x70;&#x6f;x&#101;&#x6c;p&#104;&#97;&#x72;m&#97;&#x2e;&#x63;o&#109;\" rel=\"nofollow noopener\" shape=\"rect\">&#97;&#x75;&#114;&#x65;&#108;&#x69;e&#x2e;b&#111;&#x7a;&#122;&#x61;&#64;&#x70;o&#x78;e&#108;&#x70;&#104;&#x61;&#114;&#x6d;&#97;&#x2e;c&#x6f;m<\/a><br \/>+33 6 99 81 08 36<\/p>\n<p>\nElizabeth Woo<br \/>\n<br \/>Senior Vice President, Investor Relations &amp; Communication<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#x69;&#x6c;&#116;&#111;&#58;&#101;liz&#x61;&#x62;&#x65;&#x74;&#x68;&#46;&#119;&#111;o&#64;p&#x6f;&#x78;&#x65;&#x6c;&#x70;&#104;&#97;&#114;ma&#46;&#x63;&#x6f;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#x65;&#x6c;&#105;za&#x62;&#x65;&#116;&#104;&#46;&#x77;&#x6f;&#111;&#64;p&#x6f;&#x78;&#x65;&#108;ph&#x61;&#x72;&#109;&#97;&#46;&#x63;&#x6f;&#109;<\/a><\/p>\n<p>\nNewCap<br \/>\n<br \/>Emmanuel Huynh or Arthur Rouill\u00e9<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#105;&#108;t&#x6f;&#x3a;&#x70;&#111;xe&#x6c;&#x40;&#110;&#101;w&#x63;&#x61;&#x70;&#46;eu\" rel=\"nofollow noopener\" shape=\"rect\">&#x70;o&#x78;e&#x6c;&#64;&#x6e;&#101;w&#x63;a&#x70;&#46;&#x65;&#117;<\/a><br \/>+33 1 44 71 94 94<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nine Imeglimin abstracts to be presented at the 66th Annual Meeting of the Japanese Diabetes Society LYON, France&#8211;(BUSINESS WIRE)&#8211;Regulatory News: POXEL SA (Euronext: POXEL &#8211; FR0012432516) (Paris:POXEL), a clinical stage biopharmaceutical company developing innovative treatments for serious chronic diseases with metabolic pathophysiology, including non-alcoholic steatohepatitis (NASH) and rare metabolic disorders, announced today that nine abstracts &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/poxel-announces-multiple-twymeeg-imeglimin-abstracts-accepted-for-oral-presentation\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-56061","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Poxel Announces Multiple TWYMEEG\u00ae (Imeglimin) Abstracts Accepted for Oral Presentation - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/poxel-announces-multiple-twymeeg-imeglimin-abstracts-accepted-for-oral-presentation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Poxel Announces Multiple TWYMEEG\u00ae (Imeglimin) Abstracts Accepted for Oral Presentation - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Nine Imeglimin abstracts to be presented at the 66th Annual Meeting of the Japanese Diabetes Society LYON, France&#8211;(BUSINESS WIRE)&#8211;Regulatory News: POXEL SA (Euronext: POXEL &#8211; FR0012432516) (Paris:POXEL), a clinical stage biopharmaceutical company developing innovative treatments for serious chronic diseases with metabolic pathophysiology, including non-alcoholic steatohepatitis (NASH) and rare metabolic disorders, announced today that nine abstracts ... 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