{"id":57478,"date":"2023-05-26T10:03:29","date_gmt":"2023-05-26T08:03:29","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/transgene-to-present-data-on-its-two-therapeutic-cancer-vaccines-at-the-2023-american-society-of-clinical-oncology-asco-annual-meeting\/"},"modified":"2023-05-26T10:03:29","modified_gmt":"2023-05-26T08:03:29","slug":"transgene-to-present-data-on-its-two-therapeutic-cancer-vaccines-at-the-2023-american-society-of-clinical-oncology-asco-annual-meeting","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/transgene-to-present-data-on-its-two-therapeutic-cancer-vaccines-at-the-2023-american-society-of-clinical-oncology-asco-annual-meeting\/","title":{"rendered":"Transgene to Present Data on its Two Therapeutic Cancer Vaccines at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting"},"content":{"rendered":"
\n

\nPresentations include new data further demonstrating the immune responses induced by TG4001 and recently updated results from the adjuvant Phase I trial of neoantigen vaccine TG4050 in head and neck cancer<\/p>\n

<\/a><\/p>\n

STRASBOURG, France–(BUSINESS WIRE)–#HBV<\/a>–Regulatory News:<\/p>\n

\nTransgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer,<\/b> announced two poster presentations at the 2023 American Association of Clinical Oncology (ASCO) annual meeting <\/b>to be held in Chicago, IL (June 2-6).<\/p>\n

\nThe posters will highlight that in challenging clinical settings<\/b>:<\/p>\n

\n\u2713 TG4001 induced T-cell responses against HPV16 antigens in the ongoing Phase II trial.
\n
<\/b>\u2713 TG4050: 100% of the patients treated with the individualized therapeutic cancer vaccine developed multiple functional T cell responses against targeted neoantigens, <\/b>which may be associated with an improved outcome in patients with head and neck cancer in the adjuvant setting.<\/p>\n

\nDetails for the presentations are as follows:<\/p>\n

\nTG4001
\n
Abstract Title: <\/b>Immunogenicity and clinical activity of tipapkinogen sovacivec (TG4001), an HPV-16 cancer vaccine: A randomized phase 2 study in advanced anogenital cancers.
\n
<\/i>Abstract Number: <\/b>2630
\n
Session Title: <\/b>Developmental Therapeutics\u2014Immunotherapy
\n
Session Date and Time: <\/b>Saturday, June 3, 2023, 8:00 AM-11:00 AM (CDT)
\n
Link to the abstract: click here<\/a><\/p>\n

\nTG4050
\n
Abstract Title: <\/b>Safety and immunogenicity of TG4050: A personalized cancer vaccine in head and neck carcinoma.
\n
<\/i>Abstract Number: <\/b>6082
\n
Session Title: <\/b>Head and Neck Cancer
\n
Session Date and Time<\/b>: Monday, June 5, 2023, 1:15 PM-4:15 PM <\/b>(CDT)
\n
Link to the abstract: click here<\/a><\/p>\n

\nThe abstracts are available on Transgene\u2019s website<\/a>.<\/p>\n

\n***<\/p>\n

\nAbout TG4001
\n
<\/i><\/b>TG4001 is an investigational therapeutic vaccine based on a non-propagative, highly attenuated Vaccinia vector (MVA), which is engineered to express HPV16 antigens (E6 & E7) and an adjuvant (IL-2). TG4001 is designed to have a two-pronged antiviral approach: to alert the immune system specifically to cells presenting the HPV16 E6 and E7 antigens, that can be found in HPV16-related tumors, and to further stimulate the infection-clearing activity of the immune system through interleukin 2 (IL-2). TG4001 has been administered to more than 350 individuals, demonstrating good safety and promising efficacy results [1]<\/a><\/sup>. Its mechanism of action and good safety profile make TG4001 an excellent candidate for combinations with other therapies in HPV-mediated solid tumors.<\/p>\n

\nIt is currently evaluated in a multi-center, open label, randomized Phase II trial (NCT03260023) designed to compare the efficacy of the combination of TG4001 and avelumab versus avelumab alone in patients with advanced, recurrent and\/or metastatic HPV16-positive anogenital cancers who have disease progression after a maximum of one line of systemic treatment, or who are not eligible for first-line chemotherapy.<\/p>\n

\nAbout TG4050
\n
<\/i><\/b>TG4050 is an individualized immunotherapy being developed for solid tumors that is based on Transgene\u2019s myvac<\/i>\u00ae technology and powered by NEC\u2019s longstanding artificial intelligence (AI) expertise. This virus-based therapeutic vaccine encodes neoantigens (patient-specific mutations) identified and selected by NEC\u2019s Neoantigen Prediction System. The prediction system is based on more than two decades of expertise in AI and has been trained on proprietary data allowing it to accurately prioritize and select the most immunogenic sequences.<\/p>\n

\nTG4050 is designed to stimulate the immune system of patients in order to induce a T-cell response that is able to recognize and destroy tumor cells based on their own neoantigens. This individualized immunotherapy is developed and produced for each patient.<\/p>\n

\nTG4050 is being evaluated in two Phase I clinical trials for patients with HPV-negative head and neck cancers (NCT04183166<\/a>) and ovarian cancer (NCT03839524<\/a>), and has shown promising initial results.<\/p>\n

\nAbout Transgene
\n
<\/i><\/b>Transgene (Euronext: TNG) is a biotechnology company focused on designing and developing targeted immunotherapies for the treatment of cancer. Transgene\u2019s programs utilize viral vector technology with the goal of indirectly or directly killing cancer cells.<\/p>\n

\nThe Company\u2019s clinical-stage programs consist of a portfolio of therapeutic vaccines and oncolytic viruses:<\/p>\n

\nTG4050, the first individualized therapeutic vaccine based on the myvac<\/i>\u00ae platform, TG4001 for the treatment of HPV-positive cancers, as well as TG6002, BT-001 and TG6050, three oncolytic viruses based on the Invir.IO\u00ae viral backbone.<\/p>\n

\nWith Transgene\u2019s myvac<\/i>\u00ae platform, therapeutic vaccination enters the field of precision medicine with a novel immunotherapy that is fully tailored to each individual. The myvac<\/i>\u00ae approach allows the generation of a virus-based immunotherapy that encodes patient-specific mutations identified and selected by Artificial Intelligence capabilities provided by its partner NEC.<\/p>\n

\nWith its proprietary platform Invir.IO\u00ae, Transgene is building on its viral vector engineering expertise to design a new generation of multifunctional oncolytic viruses.<\/p>\n

\nAdditional information about Transgene is available at: www.transgene.fr<\/a><\/p>\n

\nFollow us on social media: Twitter: @TransgeneSA<\/a> and LinkedIn: @Transgene<\/a><\/p>\n

\nDisclaimer
\n
<\/i><\/b>This press release contains forward-looking statements, which are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. The occurrence of any of these risks could have a significant negative outcome for the Company\u2019s activities, perspectives, financial situation, results, regulatory authorities\u2019 agreement with development phases, and development. The Company\u2019s ability to commercialize its products depends on but is not limited to the following factors: positive pre-clinical data may not be predictive of human clinical results, the success of clinical studies, the ability to obtain financing and\/or partnerships for product manufacturing, development and commercialization, and marketing approval by government regulatory authorities. For a discussion of risks and uncertainties which could cause the Company\u2019s actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (\u201cFacteurs de Risque\u201d) section of the Universal Registration Document, available on the AMF website (http:\/\/www.amf-france.org<\/a>) or on Transgene\u2019s website (www.transgene.fr<\/a>). Forward-looking statements speak only as of the date on which they are made, and Transgene undertakes no obligation to update these forward-looking statements, even if new information becomes available in the future.<\/i><\/p>\n

Contacts<\/b> <\/p>\n

\nTransgene:<\/b>
Lucie Larguier<\/b>
Director Corporate Communications & IR
\n
+33 (0)3 88 27 91 04
\n
investorrelations@transgene.fr<\/a><\/p>\n

Media: MEDiSTRAVA Consulting<\/b>
David Dible\/Sylvie Berrebi<\/b>
+44 (0)203 928 6900
\n
transgene@medistrava.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Presentations include new data further demonstrating the immune responses induced by TG4001 and recently updated results from the adjuvant Phase I trial of neoantigen vaccine TG4050 in head and neck cancer STRASBOURG, France–(BUSINESS WIRE)–#HBV–Regulatory News: Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, announced two … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-57478","6":"format-standard","7":"category-industry"},"yoast_head":"\nTransgene to Present Data on its Two Therapeutic Cancer Vaccines at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/transgene-to-present-data-on-its-two-therapeutic-cancer-vaccines-at-the-2023-american-society-of-clinical-oncology-asco-annual-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Transgene to Present Data on its Two Therapeutic Cancer Vaccines at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Presentations include new data further demonstrating the immune responses induced by TG4001 and recently updated results from the adjuvant Phase I trial of neoantigen vaccine TG4050 in head and neck cancer STRASBOURG, France–(BUSINESS WIRE)–#HBV–Regulatory News: Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, announced two ... 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