{"id":58076,"date":"2023-09-19T22:05:14","date_gmt":"2023-09-19T20:05:14","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/atara-biotherapeutics-announces-plans-to-submit-tab-cel-bla-in-q2-2024-following-fda-agreement-on-comparability\/"},"modified":"2023-09-19T22:05:14","modified_gmt":"2023-09-19T20:05:14","slug":"atara-biotherapeutics-announces-plans-to-submit-tab-cel-bla-in-q2-2024-following-fda-agreement-on-comparability","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/atara-biotherapeutics-announces-plans-to-submit-tab-cel-bla-in-q2-2024-following-fda-agreement-on-comparability\/","title":{"rendered":"Atara Biotherapeutics Announces Plans to Submit Tab-cel\u00ae BLA in Q2 2024 Following FDA Agreement on Comparability"},"content":{"rendered":"
\n

THOUSAND OAKS, Calif.–(BUSINESS WIRE)–$ATRA<\/a> #CART<\/a>—Atara Biotherapeutics, Inc.<\/a> (Nasdaq: ATRA), a leader in T-cell immunotherapy, leveraging its novel allogeneic Epstein-Barr virus (EBV) T-cell platform to develop transformative therapies for patients with cancer and autoimmune diseases, today reported important progress related to the regulatory pathway for tabelecleucel (tab-cel\u00ae<\/sup><\/b>) in the U.S.<\/p>\n

<\/a>
<\/a><\/p>\n

\nFollowing productive discussions between Atara and the U.S. Food and Drug Administration (FDA), the FDA and Atara are now aligned on analytical comparability between manufacturing process versions. This alignment supports Atara’s ability to pool the pivotal clinical trial data from different process versions in the Biologics License Application (BLA) submission.<\/p>\n

\nAtara expects to submit the tab-cel BLA in Q2 2024, which will enable Atara to incorporate the latest tab-cel pivotal trial data from the ALLELE study into the BLA filing package.<\/p>\n

\n\u201cWe are pleased with the FDA\u2019s positive assessment and conclusion of comparability, and we look forward to progressing to the next stage of preparing our BLA submission for tab-cel,\u201d said Pascal Touchon, President and Chief Executive Officer of Atara. \u201cFollowing this clarity, we can also continue to advance our U.S. partnership discussions with several parties, selecting the best possible partner to bring this potentially life-saving treatment to patients.\u201d<\/p>\n

\nTabelecleucel is an allogeneic, EBV-specific T-cell immunotherapy which targets and eliminates EBV-infected cells in an HLA-restricted manner. Epstein-Barr virus-positive post-transplant lymphoproliferative disease (EBV+ PTLD) is a rare, acute, and potentially deadly hematologic malignancy that occurs after transplantation when patient T-cell immune responses are compromised by immunosuppression. It can impact patients who have undergone solid organ transplant (SOT) or allogeneic hematopoietic cell transplant (HCT). Poor median survival of 0.7 months and 4.1 months for HCT and SOT, respectively, is reported in EBV+ PTLD patients for whom standard of care failed, underscoring the significant need for new therapeutic options.<\/p>\n

\nTabelecleucel is commercialized by Pierre Fabre in Europe as EBVALLO\u2122 following European Commission marketing authorization in December 2022. In Europe, EBVALLO\u2122 is indicated as a monotherapy for the treatment of adult and pediatric patients two years of age and older with relapsed or refractory EBV+ PTLD who have received at least one prior therapy. For solid organ transplant patients, prior therapy includes chemotherapy, unless chemotherapy is inappropriate.<\/p>\n

\nAbout Atara Biotherapeutics, Inc.
\n
<\/b>Atara is harnessing the natural power of the immune system to develop off-the-shelf cell therapies for difficult-to-treat cancers and autoimmune conditions, including multiple sclerosis, that can be rapidly delivered to patients within days. With cutting-edge science and differentiated approach, Atara is the first company in the world to receive regulatory approval of an allogeneic T-cell immunotherapy. Our advanced and versatile Epstein-Barr virus (EBV) T-cell platform does not require T-cell receptor or HLA gene editing and forms the basis of a diverse portfolio of investigational therapies that target EBV, the root cause of certain diseases, in addition to next-generation AlloCAR-Ts designed for best-in-class opportunities across a broad range of non-EBV-associated liquid and solid tumors. Atara is headquartered in Southern California. For more information, visit atarabio.com<\/a> and follow @Atarabio<\/a> on X<\/a> (formerly known as Twitter) and LinkedIn<\/a>.<\/p>\n

\nForward-Looking Statements
\n
<\/b>This press release contains or may imply “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. For example, forward-looking statements include statements regarding: (1) dialogue with the FDA regarding a potential BLA submission for tab-cel; (2) tab-cel clinical trials, and the occurrence, timing and outcome of Atara\u2019s interactions and discussions with the FDA regarding a BLA submission for tab-cel, including the pooling of pivotal clinical trial data from different process versions in a BLA submission; (3) the potential submission of a BLA for tab-cel; and (4) the timing and progress of Atara\u2019s discussions with potential commercial partners for tab-cel in the U.S. Because such statements deal with future events and are based on Atara\u2019s current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Atara could differ materially from those described in or implied by the statements in this press release. These forward-looking statements are subject to risks and uncertainties, including, without limitation, risks and uncertainties associated with the costly and time-consuming pharmaceutical product development process and the uncertainty of clinical success; the ongoing COVID-19 pandemic and the war in Ukraine, which may significantly impact (i) our business, research, clinical development plans and operations, including our operations in Southern California and Denver and at our clinical trial sites, as well as the business or operations of our third-party manufacturer, contract research organizations or other third parties with whom we conduct business, (ii) our ability to access capital, and (iii) the value of our common stock; the sufficiency of Atara\u2019s cash resources and need for additional capital; and other risks and uncertainties affecting Atara\u2019s and its development programs, including those discussed in Atara\u2019s filings with the Securities and Exchange Commission , including in the \u201cRisk Factors\u201d and \u201cManagement\u2019s Discussion and Analysis of Financial Condition and Results of Operations\u201d sections of the Company\u2019s most recently filed periodic reports on Form 10-K and Form 10-Q and subsequent filings and in the documents incorporated by reference therein. Except as otherwise required by law, Atara disclaims any intention or obligation to update or revise any forward-looking statements, which speak only as of the date hereof, whether as a result of new information, future events or circumstances or otherwise.<\/p>\n

Contacts<\/b> <\/p>\n

\nInvestor and Media Relations:<\/b><\/p>\n

\nAlex Chapman
\n
Vice President, Corporate Communications & Investor Relations
\n
(805) 456-4772
\n
achapman@atarabio.com<\/a><\/p>\n

\nJason Awe, Ph.D.
\n
Senior Director, Corporate Communications & Investor Relations
\n
(805) 217-2287
\n
jawe@atarabio.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

THOUSAND OAKS, Calif.–(BUSINESS WIRE)–$ATRA #CART—Atara Biotherapeutics, Inc. (Nasdaq: ATRA), a leader in T-cell immunotherapy, leveraging its novel allogeneic Epstein-Barr virus (EBV) T-cell platform to develop transformative therapies for patients with cancer and autoimmune diseases, today reported important progress related to the regulatory pathway for tabelecleucel (tab-cel\u00ae) in the U.S. Following productive discussions between Atara and … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-58076","6":"format-standard","7":"category-industry"},"yoast_head":"\nAtara Biotherapeutics Announces Plans to Submit Tab-cel\u00ae BLA in Q2 2024 Following FDA Agreement on Comparability - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/atara-biotherapeutics-announces-plans-to-submit-tab-cel-bla-in-q2-2024-following-fda-agreement-on-comparability\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Atara Biotherapeutics Announces Plans to Submit Tab-cel\u00ae BLA in Q2 2024 Following FDA Agreement on Comparability - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"THOUSAND OAKS, Calif.–(BUSINESS WIRE)–$ATRA #CART—Atara Biotherapeutics, Inc. (Nasdaq: ATRA), a leader in T-cell immunotherapy, leveraging its novel allogeneic Epstein-Barr virus (EBV) T-cell platform to develop transformative therapies for patients with cancer and autoimmune diseases, today reported important progress related to the regulatory pathway for tabelecleucel (tab-cel\u00ae) in the U.S. Following productive discussions between Atara and ... 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