{"id":58655,"date":"2024-01-02T10:05:09","date_gmt":"2024-01-02T09:05:09","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/nanophoria-bioscience-publishes-groundbreaking-study-in-major-cardiology-journal\/"},"modified":"2024-01-02T10:05:09","modified_gmt":"2024-01-02T09:05:09","slug":"nanophoria-bioscience-publishes-groundbreaking-study-in-major-cardiology-journal","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/nanophoria-bioscience-publishes-groundbreaking-study-in-major-cardiology-journal\/","title":{"rendered":"NanoPhoria Bioscience Publishes Groundbreaking Study in Major Cardiology Journal"},"content":{"rendered":"<div>\n<p class=\"bwalignc\">\n<i>Data\u00a0confirms pivotal role of a lung-to-heart nano-in-micro technology, with first-in-class ejection fraction modulator (NP-MP1) that improves cardiac contractility in the treatment of chronic heart failure<\/i><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nFirst-ever data from a lung-to-heart nano-in-micro technology (LungToHeartNiM ) for a non-invasive and quick way to release a therapeutic biologic into cardiomyocytes<\/li>\n<li>\nA first proof of concept of the therapeutic effect of a calcium channel peptide modulator in a clinically relevant large animal model of heart failure.<\/li>\n<li>\nPotential benefits include restored heart function, reversal of cardiac remodeling, and reduced pulmonary congestion. These benefits could lead to a recovery of normal physiological function.<\/li>\n<li>\nPeer-reviewed publication in the prestigious Journal of the American College of Cardiology (JACC) is a testament to the high-quality and impactful work of our researchers.<\/li>\n<\/ul>\n<p>MILAN&#8211;(BUSINESS WIRE)&#8211;NanoPhoria srl, a pre-clinical stage biotech company, is pleased to announce today the publication of a groundbreaking study in the field of cardiology, conducted using a clinically relevant pig model of heart failure. This significant piece of preclinical research, titled \u201c<b>Lung-to-Heart Nano-in-Micro Peptide Promotes Cardiac Recovery in a Pig Model of Chronic Heart Failure,\u201d<\/b> was published by our co-founders in the Journal of the American College of Cardiology (JACC), a prominent peer-reviewed medical journal.<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20240102040478\/en\/1982905\/5\/Nanophoria_0000_Nanophoria.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20240102040478\/en\/1982905\/21\/Nanophoria_0000_Nanophoria.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20240102040478\/en\/1982905\/5\/Nanophoria_0000_Nanophoria.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20240102040478\/en\/1982905\/22\/Nanophoria_0000_Nanophoria.jpg\"><\/a><\/p>\n<p>\nThe<b> <\/b>innovative<b> <\/b>study, led by Alessio Alogna, MD, PhD and Daniele Catalucci PhD, assessed tolerability and efficacy of the inhalable LungToHeartNiM formulation for cardiac-specific delivery of a therapeutic peptide, a first-in-class biologic designed to reorganize impaired L-type calcium channel (LTCC) subcellular trafficking.<\/p>\n<p>\nUsing an established pig model, which closely mimics human heart failure with reduced ejection fraction, our research team has uncovered critical insights that could pave the way for novel treatments.<\/p>\n<p>\nThe research demonstrates significant and remarkable findings, including:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nEffectiveness of the LungToHeartNiM technology, used for the daily inhalation of the therapeutic peptide to improve heart function (<i>as shown by an absolute left ventricle ejection fraction increase over the treatment period of 17% +\/- 6%)<\/i>, blunt myocardial fibrosis, and reduce pulmonary congestion.<\/li>\n<li>\nIncreased left ventricle contractility and improved ventriculo-arterial coupling with no further energetic costs: no increase in heart rate, no increase in blood pressure and no cardiac arrythmias.<\/li>\n<li>\nGood tolerability and no major adverse events from the treatment.<\/li>\n<li>\nResults confirming the therapeutic effect recapitulated ex vivo in cardiac myofibrils and biopsies from treated heart failure animals.<\/li>\n<\/ul>\n<p>\nThese findings mark a substantial advancement in understanding heart failure\u2019s mechanisms and finding potential new therapeutic targets.<\/p>\n<p>\n\u201cThe overall tolerability of LungToHeartNiM, along with the beneficial effects of reorganizing dysregulated LTCCs, may represent a game-changing treatment for patients with heart failure,\u201d said Alessio Alogna and Daniele Catalucci, co-founders of NanoPhoria. \u201cAdditionally, our research showcases a major advancement in the field of heart disease treatment. We have effectively demonstrated an innovative and non-invasive approach to delivering a therapeutic peptide, an LTCC modulator, directly to cardiomyocytes of the diseased heart. This method stands out as it avoids the complexities and risks associated with current invasive techniques, like injections directly into the heart muscle or coronary arteries. Our approach not only simplifies the treatment process but also significantly reduces the discomfort and potential complications for patients.&#8221;<\/p>\n<p>\n\u201cWe are enthusiastic about the outcome of this study,\u201d said Claudio De Luca, co-founder and CEO of NanoPhoria,\u201c as it strongly supports the current development of our lead product, NP-MP1, which is now approaching the clinical phases. It also confirms the potential effectiveness of our delivery platform for our future product pipeline.\u201d<\/p>\n<p>\n&#8220;<b>This research is supportive of the innovative lung-to-heart delivery approach. It confirms the potential disease modifying role of the calcium channel modulator peptide leading to fast improvement in cardiac ejection fraction, and offers promising new directions for the treatment and management of heart failure,\u201d <\/b>said James L. Januzzi Jr MD, FACC, FESC, Professor of Medicine at Harvard Medical School, and Director, Heart Failure and Biomarker Trials (Baim Institute) Cardiology Division, Massachusetts General Hospital.<\/p>\n<p>\nBuilding on these findings, NanoPhoria plans to extend this research into clinical trials, aiming to translate these initial, remarkable preclinical results into better treatment options and a potential paradigm change in the treatment of heart failure.<\/p>\n<p>\n<b>About NanoPhoria<br \/>\n<br \/><\/b>NanoPhoria is a biotech company based in Milan that is developing a versatile, non-viral drug delivery platform based on inorganic nanoparticles. The company&#8217;s first product is a pre-clinical stage treatment for heart failure with reduced ejection fraction (HFrEF), a chronic syndrome affecting the lives of millions worldwide. NanoPhoria is a spin-off from CNR, the largest public research institution in Italy, and is supported by Sofinnova Partners.<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<a target=\"_blank\" href=\"&#109;a&#x69;l&#x74;o&#x3a;&#67;&#x6c;&#97;&#x75;&#100;i&#x6f;&#46;&#x64;e&#x6c;&#117;&#x63;&#97;&#x40;&#110;&#x61;&#110;o&#x70;h&#x6f;r&#x69;&#97;&#x2e;&#99;&#x6f;&#109;\" rel=\"nofollow noopener\" shape=\"rect\">Claudio&#46;&#100;&#101;&#108;&#117;&#99;&#97;&#64;&#110;&#97;&#110;&#x6f;&#x70;&#x68;&#x6f;&#x72;&#x69;&#x61;&#x2e;&#x63;&#x6f;&#x6d;<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Data\u00a0confirms pivotal role of a lung-to-heart nano-in-micro technology, with first-in-class ejection fraction modulator (NP-MP1) that improves cardiac contractility in the treatment of chronic heart failure First-ever data from a lung-to-heart nano-in-micro technology (LungToHeartNiM ) for a non-invasive and quick way to release a therapeutic biologic into cardiomyocytes A first proof of concept of the therapeutic &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/nanophoria-bioscience-publishes-groundbreaking-study-in-major-cardiology-journal\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-58655","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NanoPhoria Bioscience Publishes Groundbreaking Study in Major Cardiology Journal - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/nanophoria-bioscience-publishes-groundbreaking-study-in-major-cardiology-journal\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NanoPhoria Bioscience Publishes Groundbreaking Study in Major Cardiology Journal - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Data\u00a0confirms pivotal role of a lung-to-heart nano-in-micro technology, with first-in-class ejection fraction modulator (NP-MP1) that improves cardiac contractility in the treatment of chronic heart failure First-ever data from a lung-to-heart nano-in-micro technology (LungToHeartNiM ) for a non-invasive and quick way to release a therapeutic biologic into cardiomyocytes A first proof of concept of the therapeutic ... 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