{"id":59096,"date":"2024-03-25T13:02:19","date_gmt":"2024-03-25T12:02:19","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/bristol-myers-squibb-to-present-data-at-the-american-college-of-cardiology-annual-scientific-session-2024-reinforcing-extensive-body-of-evidence-in-clinical-and-real-world-settings-across-cardiovascul\/"},"modified":"2024-03-25T13:02:19","modified_gmt":"2024-03-25T12:02:19","slug":"bristol-myers-squibb-to-present-data-at-the-american-college-of-cardiology-annual-scientific-session-2024-reinforcing-extensive-body-of-evidence-in-clinical-and-real-world-settings-across-cardiovascul","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/bristol-myers-squibb-to-present-data-at-the-american-college-of-cardiology-annual-scientific-session-2024-reinforcing-extensive-body-of-evidence-in-clinical-and-real-world-settings-across-cardiovascul\/","title":{"rendered":"Bristol Myers Squibb to Present Data at the American College of Cardiology Annual Scientific Session 2024 Reinforcing Extensive Body of Evidence in Clinical and Real-World Settings Across Cardiovascular Portfolio"},"content":{"rendered":"<div>\n<p class=\"bwalignc\">\n<b><i>Analysis from a 10-month post-launch evaluation of the REMS Program finds 2.8% incidence of LVEF &lt;50% in over 1500 patients, strengthening the safety profile of <\/i>CAMZYOS<sup>\u00ae<\/sup><i> <\/i>(mavacamten)<i> for NYHA class II-III obstructive hypertrophic cardiomyopathy<\/i><\/b><\/p>\n<p class=\"bwalignc\">\n<b><i>Real-world data reaffirm therapeutic value and treatment benefit of <\/i>CAMZYOS <i>in improving cardiac symptoms and NYHA class in patients with obstructive hypertrophic cardiomyopathy<\/i><\/b><\/p>\n<p>PRINCETON, N.J.&#8211;(BUSINESS WIRE)&#8211;<a href=\"https:\/\/twitter.com\/search?q=%24BMY&amp;src=ctag\" target=\"_blank\" rel=\"noopener\">$BMY<\/a> <a href=\"https:\/\/twitter.com\/hashtag\/ACC?src=hash\" target=\"_blank\" rel=\"noopener\">#ACC<\/a>&#8212;<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.bms.com%2F&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=Bristol+Myers+Squibb&amp;index=1&amp;md5=1279927031acb685fa2f8562b7a8de1d\" rel=\"nofollow noopener\" shape=\"rect\">Bristol Myers Squibb<\/a> (NYSE: BMY) today announced the presentation of data at the American College of Cardiology (ACC) Annual Scientific Session &amp; Expo, taking place April 6-8, 2024 in Atlanta, Georgia.<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20240322953592\/en\/2041631\/5\/bms_logo_300_rgb_pos.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20240322953592\/en\/2041631\/22\/bms_logo_300_rgb_pos.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20240322953592\/en\/2041631\/5\/bms_logo_300_rgb_pos.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20240322953592\/en\/2041631\/21\/bms_logo_300_rgb_pos.jpg\"><\/a><\/p>\n<p>\n\u201cThe therapeutic benefit of CAMZYOS in real-world practice, demonstrated by our data at ACC, builds on the well-established clinical program and further underscores the importance of this transformational medicine which is the first and only approved cardiac myosin inhibitor. With thousands of patients around the world treated to date, CAMZYOS is redefining the treatment landscape for this patient population and may offer hope to countless others moving forward,\u201d said <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.bms.com%2Fresearchers-and-partners%2Four-r-and-d-team%2Fresearchers-bios%2Ffeatured-researcher-roland-chen.html&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=Roland+Chen%2C+MD&amp;index=2&amp;md5=6b1dcaab7e7cc3aa951aefe6d3468ce7\" rel=\"nofollow noopener\" shape=\"rect\">Roland Chen, MD<\/a>, Senior Vice President and Head of Development, Immunology, Cardiovascular &amp; Neurology. \u201cIn addition to showcasing our growing body of real-world evidence and safety data for CAMZYOS at ACC, we look forward to highlighting additional data from our cardiovascular portfolio, including an analysis of the real-world clinical impact of ELIQUIS.\u201d<\/p>\n<p>\nResearch to be presented at the meeting supports the robust safety and clinical profile of CAMZYOS<i><sup>\u00ae<\/sup><\/i> (mavacamten) and compliance with the Risk Evaluation and Mitigation Strategy (REMS) Program. These data include:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nAn analysis of results from the 10-month post-launch evaluation of the CAMZYOS REMS Program in 1,524 patients with patient status forms submitted, which demonstrated that approximately 1% (n=17) of patients reported clinical heart failure requiring hospitalization and 2.8% (n=43) of patients reported a decrease in left ventricular ejection fraction (LVEF) to &lt;50%. These data are consistent with the clinical development program and reinforce the safety profile of CAMZYOS in clinical practice.<\/p>\n<ul class=\"bwlistcircle\">\n<li>\nThese data (abstract 1075-07) will be featured as a moderated poster on Sunday, April 7 from 1:30 PM \u2013 1:40 PM ET.<\/li>\n<\/ul>\n<\/li>\n<li>\nA single-center real-world experience analysis of 53 patients treated with CAMZYOS which found that at 24 weeks, CAMZYOS led to improvements in cardiovascular symptoms (96%) and improvements in one or more New York Heart Association (NYHA) class (49%). Additionally, resting and Valsalva LVOT gradient decreased during the first four weeks after starting treatment, with statistically significant reductions from baseline at week 24 (P&lt;0.001). No patients required cessation of treatment due to reduction of LVEF to &lt;50% or other side effects, though two patients required temporary drug discontinuation due to Valsalva LVOT gradient less than 20 mmHg during the 24-week treatment period.<\/p>\n<ul class=\"bwlistcircle\">\n<li>\nThese data (abstract 1424-134) will be featured as a poster on Sunday, April 7 from 1:15 PM \u2013 2:00 PM ET.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\nThe BMS-Pfizer Alliance will also present research at the meeting that adds to the robust body of evidence pertaining to the safety and efficacy profile of ELIQUIS<i><sup>\u00ae<\/sup><\/i> (apixaban). These data include:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nA real-world evidence study of non-valvular atrial fibrillation (NVAF) patients on Medicare previously treated with warfarin and switched to a direct oral anticoagulant (DOAC: apixaban, dabigatran, or rivaroxaban), which found that those who received ELIQUIS had a statistically significant lower risk of stroke\/systemic embolism (S\/SE) and major bleeding (MB) than those patients who received rivaroxaban (S\/SE HR: 0.91; 95% CI: 0.85-0.97 and MB HR: 0.68; 95% CI: 0.65-0.72) or dabigatran (S\/SE HR: 0.83; 95% CI: 0.72-0.96 and MB HR: 0.79; 95% CI: 0.71-0.89). This pairwise comparative analysis provides the rates of S\/SE and MB shown in patients with NVAF on Medicare associated with switching from warfarin to different DOACs. This effectiveness and safety information about ELIQUIS use in clinical practice can supplement data from randomized clinical trials.<\/p>\n<ul class=\"bwlistcircle\">\n<li>\nThese data (abstract 1306-157) will be featured as a poster on Saturday, April 6 from 2:45 PM \u2013 3:00 PM ET.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\nSelect BMS and BMS-Pfizer Alliance-sponsored abstracts to be presented at ACC can be found below. Complete abstracts may be accessed online <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F10973&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=here&amp;index=3&amp;md5=e271d180484d4f8db10431ade51427eb\" rel=\"nofollow noopener\" shape=\"rect\">here<\/a>. Visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.bms.com%2Fresearchers-and-partners%2Fareas-of-focus%2Four-research-in-cardiovascular.html&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=this+page&amp;index=4&amp;md5=9099f7f84137ceb0b4349a826736988f\" rel=\"nofollow noopener\" shape=\"rect\">this page <\/a>on BMS.com for more information on Bristol Myers Squibb\u2019s scientific approach and resources on cardiovascular diseases.<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl\">\n<tr>\n<td class=\"bwtopsingle bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n<b>Abstract Title<\/b><\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n<b>Primary Author<\/b><\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n<b>Type\/#<\/b><\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n<b>Session Title<\/b><\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n<b>Time (ET)<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0\" colspan=\"5\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b><i>Saturday, April 6, 2024<\/i><\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nThe experiences, values and goals of people in Australia living with obstructive hypertrophic cardiomyopathy: In-depth patient interviews<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nFifer, S.<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nPoster \u2013 <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F10973%2Fpresentation%2F19300&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=1244-128&amp;index=5&amp;md5=e5396abc5349ca61f502604ca4c3004e\" rel=\"nofollow noopener\" shape=\"rect\">1244-128<\/a><\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>1244 <\/b>&#8211;<b> <\/b>Heart Failure and Cardiomyopathies: Basic and Translational Science 03<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n11:45 AM \u2013 12:30 PM<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nEffect of mavacamten on health status in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy: Results from the EXPLORER-CN study<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nTian, Z.<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nPoster \u2013 <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F10973%2Fpresentation%2F19329&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=1284-132&amp;index=6&amp;md5=08cd47130400a9325049fa1fba1deae2\" rel=\"nofollow noopener\" shape=\"rect\">1284-132<\/a><\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>1284<\/b> &#8211; Heart Failure and Cardiomyopathies: Pharmacology 05<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n1:45 PM \u2013 2:30 PM<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nEvaluation of effectiveness and safety outcomes among Medicare patients with non-valvular atrial fibrillation who switched from warfarin to direct oral anticoagulants*<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nAtreja, N.<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nPoster \u2013 <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F10973%2Fpresentation%2F21715&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=1306-157&amp;index=7&amp;md5=69c436171483fcbab9ea27437542e4c8\" rel=\"nofollow noopener\" shape=\"rect\">1306-157<\/a><\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>1306<\/b> &#8211; Ischemic Heart Disease: Special Populations 06<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n2:45 PM \u2013<\/p>\n<p class=\"bwcellpmargin\">\n3:30 PM<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwrowaltcolor0 bwpadl0\" colspan=\"5\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b><i>Sunday, April 7, 2024<\/i><\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nGreatest absolute benefit of apixaban and limiting aspirin is in those with comorbidity: Results from the AUGUSTUS trial*<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nKrychtiuk, K.<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nPoster \u2013 <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F10973%2Fpresentation%2F11249&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=1065-11&amp;index=8&amp;md5=27ed066f220dfda94c50095c6a4e48a4\" rel=\"nofollow noopener\" shape=\"rect\">1065-11<\/a><\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>1065 <\/b>&#8211;<b> <\/b>Vascular Vistas: Tailored Research for Special Populations<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n12:00 PM \u2013 12:10 PM<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nReal-world experience and 24-week outcomes of patients with symptomatic obstructive hypertrophic cardiomyopathy treated with mavacamten in the US<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nReza, N.<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nPoster \u2013 <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F10973%2Fpresentation%2F19662&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=1424-134&amp;index=9&amp;md5=be20493700016e7aedd6b67976c07e12\" rel=\"nofollow noopener\" shape=\"rect\">1424-134<\/a><\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>1424<\/b> &#8211; Heart Failure and Cardiomyopathies: Special Populations 12<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n1:15 PM \u2013 2:00 PM<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nThe CAMZYOS (mavacamten) risk evaluation and mitigation strategy program: Results from 10 months post-launch<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nMartinez, M.<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nPoster \u2013 <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F10973%2Fpresentation%2F11645&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=1075-07&amp;index=10&amp;md5=75a6b81186a1c0511875c81f65d7c315\" rel=\"nofollow noopener\" shape=\"rect\">1075-07<\/a><\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>1075 <\/b>&#8211;<b> <\/b>Bulking Up: Advances in Hypertrophic Cardiomyopathy<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n1:30 PM \u2013 1:40 PM<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nEffects of mavacamten on circulating biomarkers in obstructive hypertrophic cardiomyopathy: Insights from the EXPLORER-HCM study using comprehensive proteomics profiling<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nWang, Z.<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nPoster \u2013 <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F10973%2Fpresentation%2F11646&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=1075-09&amp;index=11&amp;md5=cd58b1dcc9a36dd36ee1ac68f5f8732f\" rel=\"nofollow noopener\" shape=\"rect\">1075-09<\/a><\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<b>1075 <\/b>&#8211;<b> <\/b>Bulking Up: Advances in Hypertrophic Cardiomyopathy<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n1:45 PM \u2013 1:55 PM<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwpadl0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n<i>*Sponsored by the Bristol Myers Squibb-Pfizer Alliance<\/i><\/p>\n<\/td>\n<td class=\"bwpadl0\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwpadl0\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwpadl0\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"bwpadl0\" colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<\/tr>\n<\/table>\n<p>\n<b><span class=\"bwuline\">About CAMZYOS<\/span><\/b><span class=\"bwuline\"><sup>\u00ae<\/sup><b> (mavacamten)<\/b><\/span><\/p>\n<p>\nCAMZYOS<sup>\u00ae<\/sup> (mavacamten) is the first and only cardiac myosin inhibitor approved in the U.S., indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms, and in the European Union, indicated for the treatment of symptomatic (NYHA, class II-III) obstructive HCM in adult patients. It has also received regulatory approvals on five continents including in Argentina, Australia, Brazil, Canada, Great Britain, Hong Kong, Israel, Singapore, South Korea, and Switzerland. CAMZYOS is an allosteric and reversible inhibitor selective for cardiac myosin. CAMZYOS modulates the number of myosin heads that can enter \u201con actin\u201d (power-generating) states, thus reducing the probability of force-producing (systolic) and residual (diastolic) cross-bridge formation. Excess myosin actin cross-bridge formation and dysregulation of the super-relaxed state are mechanistic hallmarks of HCM. CAMZYOS shifts the overall myosin population towards an energy-sparing, recruitable, super-relaxed state. In HCM patients, myosin inhibition with CAMZYOS reduces dynamic left ventricular outflow tract (LVOT) obstruction and improves cardiac filling pressures.<\/p>\n<p>\n<b><span class=\"bwuline\">IMPORTANT SAFETY INFORMATION<\/span><\/b><\/p>\n<p>\n<b>WARNING: RISK OF HEART FAILURE<\/b><\/p>\n<p>\n<b>CAMZYOS reduces left ventricular ejection fraction (LVEF) and can cause heart failure due to systolic dysfunction.<\/b><\/p>\n<p>\n<b>Echocardiogram assessments of LVEF are required prior to and during treatment with CAMZYOS. Initiation of CAMZYOS in patients with LVEF &lt;55% is not recommended. Interrupt CAMZYOS if LVEF is &lt;50% at any visit or if the patient experiences heart failure symptoms or worsening clinical status.<\/b><\/p>\n<p>\n<b>Concomitant use of CAMZYOS with certain cytochrome P450 inhibitors or discontinuation of certain cytochrome P450 inducers may increase the risk of heart failure due to systolic dysfunction; therefore, the use of CAMZYOS is contraindicated with the following:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>Moderate to strong CYP2C19 inhibitors or strong CYP3A4 inhibitors<\/b><\/li>\n<li>\n<b>Moderate to strong CYP2C19 inducers or moderate to strong CYP3A4 inducers<\/b><\/li>\n<\/ul>\n<p>\n<b>Because of the risk of heart failure due to systolic dysfunction, CAMZYOS is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the CAMZYOS REMS PROGRAM.<\/b><\/p>\n<p>\n<b><span class=\"bwuline\">CONTRAINDICATIONS<\/span><\/b><\/p>\n<p>\nCAMZYOS is contraindicated with concomitant use of:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nModerate to strong CYP2C19 inhibitors or strong CYP3A4 inhibitors<\/li>\n<li>\nModerate to strong CYP2C19 inducers or moderate to strong CYP3A4 inducers<\/li>\n<\/ul>\n<p>\n<b>WARNINGS AND PRECAUTIONS<\/b><\/p>\n<p>\n<b>Heart Failure<\/b><\/p>\n<p>\nCAMZYOS reduces systolic contraction and can cause heart failure or totally block ventricular function. Patients who experience a serious intercurrent illness (e.g., serious infection) or arrhythmia (e.g., atrial fibrillation or other uncontrolled tachyarrhythmia) are at greater risk of developing systolic dysfunction and heart failure.<\/p>\n<p>\nAssess the patient\u2019s clinical status and LVEF prior to and regularly during treatment and adjust the CAMZYOS dose accordingly. New or worsening arrhythmia, dyspnea, chest pain, fatigue, palpitations, leg edema, or elevations in N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be signs and symptoms of heart failure and should also prompt an evaluation of cardiac function.<\/p>\n<p>\nAsymptomatic LVEF reduction, intercurrent illnesses, and arrhythmias require additional dosing considerations.<\/p>\n<p>\nInitiation of CAMZYOS in patients with LVEF &lt;55% is not recommended. Avoid concomitant use of CAMZYOS in patients on disopyramide, ranolazine, verapamil with a beta blocker, or diltiazem with a beta blocker as these medications and combinations increase the risk of left ventricular systolic dysfunction and heart failure symptoms and clinical experience is limited.<\/p>\n<p>\n<b>CYP 450 Drug Interactions Leading to Heart Failure or Loss of Effectiveness<\/b><\/p>\n<p>\nCAMZYOS is primarily metabolized by CYP2C19 and CYP3A4 enzymes. Concomitant use of CAMZYOS and drugs that interact with these enzymes may lead to life-threatening drug interactions such as heart failure or loss of effectiveness.<\/p>\n<p>\nAdvise patients of the potential for drug interactions, including with over-the-counter medications (such as omeprazole, esomeprazole, or cimetidine). Advise patients to inform their healthcare provider of all concomitant products prior to and during CAMZYOS treatment.<\/p>\n<p>\n<b>CAMZYOS Risk Evaluation and Mitigation Strategy (REMS) Program<\/b><\/p>\n<p>\nCAMZYOS is only available through a restricted program called the CAMZYOS REMS Program because of the risk of heart failure due to systolic dysfunction. Notable requirements of the CAMZYOS REMS Program include the following:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nPrescribers must be certified by enrolling in the REMS Program.<\/li>\n<li>\nPatients must enroll in the REMS Program and comply with ongoing monitoring requirements.<\/li>\n<li>\nPharmacies must be certified by enrolling in the REMS Program and must only dispense to patients who are authorized to receive CAMZYOS.<\/li>\n<li>\nWholesalers and distributors must only distribute to certified pharmacies.<\/li>\n<\/ul>\n<p>\nFurther information is available at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.CAMZYOSREMS.com&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=www.CAMZYOSREMS.com&amp;index=12&amp;md5=19633592d7fea119c870c95a16ec47e7\" rel=\"nofollow noopener\" shape=\"rect\">www.CAMZYOSREMS.com<\/a> or by telephone at 1-833-628-7367.<\/p>\n<p>\n<b>Embryo-Fetal Toxicity<\/b><\/p>\n<p>\nCAMZYOS may cause fetal toxicity when administered to a pregnant female, based on animal studies. Confirm absence of pregnancy in females of reproductive potential prior to treatment and advise patients to use effective contraception during treatment with CAMZYOS and for 4 months after the last dose. CAMZYOS may reduce the effectiveness of combined hormonal contraceptives (CHCs). Advise patients using CHCs to use an alternative contraceptive method that is not affected by CYP 450 enzyme induction or to add nonhormonal contraception. Advise females of reproductive potential about the potential risk to the fetus with maternal exposure to CAMZYOS during pregnancy.<\/p>\n<p>\n<b>ADVERSE REACTIONS<\/b><\/p>\n<p>\nIn the EXPLORER-HCM trial, adverse reactions occurring in &gt;5% of patients and more commonly in the CAMZYOS group than in the placebo group were dizziness (27% vs 18%) and syncope (6% vs 2%). There were no new adverse reactions identified in VALOR-HCM.<\/p>\n<p>\n<span class=\"bwuline\">Effects on Systolic Function<\/span><\/p>\n<p>\nIn the EXPLORER-HCM trial, mean (SD) resting LVEF was 74% (6) at baseline in both treatment groups. Mean (SD) absolute change from baseline in LVEF was -4% (8) in the CAMZYOS group and 0% (7) in the placebo group over the 30-week treatment period. At Week 38, following an 8-week interruption of trial drug, mean LVEF was similar to baseline for both treatment groups. In the EXPLORER-HCM trial, 7 (6%) patients in the CAMZYOS group and 2 (2%) patients in the placebo group experienced reversible reductions in LVEF &lt;50% (median 48%: range 35-49%) while on treatment. In all 7 patients treated with CAMZYOS, LVEF recovered following interruption of CAMZYOS.<\/p>\n<p>\n<b>DRUG INTERACTIONS<\/b><\/p>\n<p>\n<b>Potential for Other Drugs to Affect Plasma Concentrations of CAMZYOS<\/b><\/p>\n<p>\nCAMZYOS is primarily metabolized by CYP2C19 and to a lesser extent by CYP3A4 and CYP2C9. Inducers and inhibitors of CYP2C19 and moderate to strong inhibitors or inducers of CYP3A4 may affect the exposures of CAMZYOS.<\/p>\n<p>\n<b><span class=\"bwuline\">Impact of Other Drugs on CAMZYOS:<\/span><\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nModerate to Strong CYP2C19 Inhibitors or Strong CYP3A4 Inhibitors: Concomitant use increases CAMZYOS exposure, which may increase the risk of heart failure due to systolic dysfunction. Concomitant use is contraindicated.<\/li>\n<li>\nModerate to Strong CYP2C19 Inducers or Moderate to Strong CYP3A4 Inducers: Concomitant use decreases CAMZYOS exposure, which may reduce CAMZYOS\u2019 efficacy. The risk of heart failure due to systolic dysfunction may increase with discontinuation of these inducers as the levels of induced enzyme normalizes. Concomitant use is contraindicated.<\/li>\n<li>\nWeak CYP2C19 Inhibitors or Moderate CYP3A4 Inhibitors: Concomitant use with a weak CYP2C19 inhibitor or a moderate CYP3A4 inhibitor increases CAMZYOS exposure, which may increase the risk of adverse drug reactions. Initiate CAMZYOS at the recommended starting dose of 5 mg orally once daily in patients who are on stable therapy with a weak CYP2C19 inhibitor or a moderate CYP3A4 inhibitor. Reduce dose of CAMZYOS by one level (i.e., 15 to 10 mg, 10 to 5 mg, or 5 to 2.5 mg) in patients who are on CAMZYOS treatment and intend to initiate a weak CYP2C19 inhibitor or a moderate CYP3A4 inhibitor. Schedule clinical and echocardiographic assessment 4 weeks after inhibitor initiation, and do not up-titrate CAMZYOS until 12 weeks after inhibitor initiation. Avoid initiation of concomitant weak CYP2C19 and moderate CYP3A4 inhibitors in patients who are on stable treatment with 2.5 mg of CAMZYOS because a lower dose is not available.<\/li>\n<\/ul>\n<p>\n<b>Potential for CAMZYOS to Affect Plasma Concentrations of Other Drugs<\/b><\/p>\n<p>\nCAMZYOS is an inducer of CYP3A4, CYP2C9, and CYP2C19. Concomitant use with CYP3A4, CYP2C19, or CYP2C9 substrates may reduce plasma concentration of these drugs. Closely monitor when CAMZYOS is used in combination with CYP3A4, CYP2C19, or CYP2C9 substrates where decreases in the plasma concentration of these drugs may reduce their activity.<\/p>\n<p>\nHormonal Contraceptives: Progestin and ethinyl estradiol are CYP3A4 substrates. Concomitant use of CAMZYOS may decrease exposures of ethinyl estradiol and progestin, which may lead to contraceptive failure or an increase in breakthrough bleeding. Advise patients to use a contraceptive method that is not affected by CYP 450 enzyme induction (e.g., intrauterine system) or add nonhormonal contraception (such as condoms) during concomitant use and for 4 months after the last dose of CAMZYOS.<\/p>\n<p>\n<b>Drugs That Reduce Cardiac Contractility<\/b><\/p>\n<p>\nExpect additive negative inotropic effects of CAMZYOS and other drugs that reduce cardiac contractility. Avoid concomitant use of CAMZYOS in patients on disopyramide, ranolazine, verapamil with a beta blocker, or diltiazem with a beta blocker as these medications and combinations increase the risk of left ventricular systolic dysfunction and heart failure symptoms and clinical experience is limited.<\/p>\n<p>\nIf concomitant therapy with a negative inotrope is initiated, or if the dose of a negative inotrope is increased, monitor LVEF closely until stable doses and clinical response have been achieved.<\/p>\n<p>\n<b>SPECIFIC POPULATIONS<\/b><\/p>\n<p>\n<b>Pregnancy<\/b><\/p>\n<p>\nCAMZYOS may cause fetal harm when administered to a pregnant female. Advise pregnant females about the potential risk to the fetus with maternal exposure to CAMZYOS during pregnancy. There is a pregnancy safety study for CAMZYOS. If CAMZYOS is administered during pregnancy, or if a patient becomes pregnant while receiving CAMZYOS or within 4 months after the last dose of CAMZYOS, healthcare providers should report CAMZYOS exposure by contacting Bristol Myers Squibb at 1-800-721-5072 or <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.bms.com&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=www.bms.com&amp;index=13&amp;md5=88975ae4eff299d81c04eb8345604f94\" rel=\"nofollow noopener\" shape=\"rect\">www.bms.com<\/a>.<\/p>\n<p>\n<b>Lactation<\/b><\/p>\n<p>\nThe presence of CAMZYOS in human or animal milk, the drug\u2019s effects on the breastfed infant, or the effects on milk production are unknown. The developmental and health benefits of breastfeeding should be considered along with the mother\u2019s clinical need for CAMZYOS and any potential adverse effects on the breastfed child from CAMZYOS or from the underlying maternal condition.<\/p>\n<p>\n<b>Females and Males of Reproductive Potential<\/b><\/p>\n<p>\nConfirm absence of pregnancy in females of reproductive potential prior to initiation of CAMZYOS. Advise females of reproductive potential to use effective contraception during treatment with CAMZYOS and for 4 months after the last dose. Use of CAMZYOS may reduce the effectiveness of CHCs. Advise patients using CHCs to use an alternative contraceptive method or add nonhormonal contraception.<\/p>\n<p>\nPlease see <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fpackageinserts.bms.com%2Fpi%2Fpi_camzyos.pdf&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=U.S.+Full+Prescribing+Information&amp;index=14&amp;md5=10ebbea35accc04d0ee63fb4e730d3a8\" rel=\"nofollow noopener\" shape=\"rect\">U.S. Full Prescribing Information<\/a>, including Boxed WARNING and <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fpackageinserts.bms.com%2Fmedguide%2Fmedguide_camzyos.pdf&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=Medication+Guide&amp;index=15&amp;md5=9dafd5298bd6c2bd9cbd5a93925f6f33\" rel=\"nofollow noopener\" shape=\"rect\">Medication Guide<\/a>.<\/p>\n<p>\n<b><span class=\"bwuline\">About ELIQUIS<\/span><\/b><span class=\"bwuline\"><i><sup> \u00ae<\/sup><\/i><b> (apixaban)<\/b><\/span><\/p>\n<p>\nELIQUIS<sup>\u00ae<\/sup> is an oral selective Factor Xa inhibitor. By inhibiting Factor Xa, a key blood clotting protein, ELIQUIS decreases thrombin generation and blood clot formation. ELIQUIS is approved for multiple indications in the U.S. based on efficacy and safety data from multiple Phase 3 clinical trials. ELIQUIS is a prescription medicine indicated to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF); for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery; for the treatment of DVT and PE; and to reduce the risk of recurrent DVT and PE, following initial therapy. ELIQUIS continues to be developed and commercialized by The Bristol Myers Squibb-Pfizer Alliance.<\/p>\n<p>\n<b>ELIQUIS Important Safety Information<\/b><\/p>\n<p>\n<b>Indications<\/b><\/p>\n<p>\nELIQUIS is indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. ELIQUIS is indicated for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery. ELIQUIS is indicated for the treatment of DVT and PE, and to reduce the risk of recurrent DVT and PE following initial therapy.<\/p>\n<p>\n<b>Important Safety Information<\/b><\/p>\n<p>\n<b>WARNING: (A) PREMATURE DISCONTINUATION OF ELIQUIS INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL\/EPIDURAL HEMATOMA<\/b><\/p>\n<p>\n<b>(A) Premature discontinuation of any oral anticoagulant, including ELIQUIS, increases the risk of thrombotic events. If anticoagulation with ELIQUIS is discontinued for a reason other than pathological bleeding or completion of a course of therapy, consider coverage with another anticoagulant.<\/b><\/p>\n<p>\n<b>(B) Epidural or spinal hematomas may occur in patients treated with ELIQUIS who are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>use of indwelling epidural catheters<\/b><\/li>\n<li>\n<b>concomitant use of other drugs that affect hemostasis, such as nonsteroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, other anticoagulants<\/b><\/li>\n<li>\n<b>a history of traumatic or repeated epidural or spinal punctures<\/b><\/li>\n<li>\n<b>a history of spinal deformity or spinal surgery<\/b><\/li>\n<li>\n<b>optimal timing between the administration of ELIQUIS and neuraxial procedures is not known<\/b><\/li>\n<\/ul>\n<p>\n<b>Monitor patients frequently for signs and symptoms of neurological<\/b> <b>impairment. If neurological compromise is noted, urgent treatment is<\/b> <b>necessary.<\/b><\/p>\n<p>\n<b>Consider the benefits and risks before neuraxial intervention in patients<\/b> <b>anticoagulated or to be anticoagulated.<\/b><\/p>\n<p>\n<b>CONTRAINDICATIONS<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nActive pathological bleeding<\/li>\n<li>\nSevere hypersensitivity reaction to ELIQUIS (e.g., anaphylactic reactions)<\/li>\n<\/ul>\n<p>\n<b>WARNINGS AND PRECAUTIONS<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>Increased Risk of Thrombotic Events after Premature Discontinuation:<\/b> Premature discontinuation of any oral anticoagulant, including ELIQUIS, in the absence of adequate alternative anticoagulation increases the risk of thrombotic events. An increased rate of stroke was observed during the transition from ELIQUIS to warfarin in clinical trials in atrial fibrillation patients. If ELIQUIS is discontinued for a reason other than pathological bleeding or completion of a course of therapy, consider coverage with another anticoagulant.<\/li>\n<li>\n<b>Bleeding Risk:<\/b> ELIQUIS increases the risk of bleeding and can cause serious, potentially fatal, bleeding.<\/li>\n<li>\nConcomitant use of drugs affecting hemostasis increases the risk of bleeding, including aspirin and other antiplatelet agents, other anticoagulants, heparin, thrombolytic agents, SSRIs, SNRIs, and NSAIDs.<\/li>\n<li>\nAdvise patients of signs and symptoms of blood loss and to report them immediately or go to an emergency room. Discontinue ELIQUIS in patients with active pathological hemorrhage.<\/li>\n<li>\nThe anticoagulant effect of apixaban can be expected to persist for at least 24 hours after the last dose (i.e., about two half-lives). An agent to reverse the anti-factor Xa activity of apixaban is available. Please visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.andexxa.com&amp;esheet=53914108&amp;newsitemid=20240322953592&amp;lan=en-US&amp;anchor=www.andexxa.com&amp;index=16&amp;md5=7e74b39ba966114c80dc0e39755581f4\" rel=\"nofollow noopener\" shape=\"rect\">www.andexxa.com<\/a> for more information on availability of a specific reversal agent.<\/li>\n<li>\n<b>Spinal\/Epidural Anesthesia or Puncture:<\/b> Patients treated with ELIQUIS undergoing spinal\/epidural anesthesia or puncture may develop an epidural or spinal hematoma which can result in long-term or permanent paralysis.<\/li>\n<\/ul>\n<p>\nThe risk of these events may be increased by the postoperative use of indwelling epidural catheters or the concomitant use of medicinal products affecting hemostasis. Indwelling epidural or intrathecal catheters should not be removed earlier than 24 hours after the last administration of ELIQUIS. The next dose of ELIQUIS should not be administered earlier than 5 hours after the removal of the catheter. The risk may also be increased by traumatic or repeated epidural or spinal puncture. If traumatic puncture occurs, delay the administration of ELIQUIS for 48 hours.<\/p>\n<p>\nMonitor patients frequently and if neurological compromise is noted, urgent diagnosis and treatment is necessary. Physicians should consider the potential benefit versus the risk of neuraxial intervention in ELIQUIS patients.<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>Prostheti<\/b><\/li>\n<\/ul>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Bristol Myers Squibb<\/b><\/p>\n<p>Media Inquiries:<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#97;&#105;&#x6c;&#x74;&#111;&#58;&#x6d;&#x65;&#100;&#105;&#x61;&#x40;&#98;&#109;&#x73;&#x2e;&#99;&#111;&#x6d;\" rel=\"nofollow noopener\" shape=\"rect\">&#109;&#x65;&#100;&#x69;&#97;&#x40;&#98;&#x6d;&#115;&#x2e;&#99;&#x6f;m<\/a><\/p>\n<p>Investors:<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#x61;&#105;&#x6c;&#116;&#x6f;&#58;&#x69;&#110;&#x76;&#101;&#x73;&#116;&#x6f;&#114;&#x2e;&#114;&#x65;&#108;&#x61;&#116;&#x69;&#111;&#x6e;&#115;&#x40;b&#x6d;s&#x2e;c&#x6f;m\" rel=\"nofollow noopener\" shape=\"rect\">&#x69;&#x6e;&#x76;&#x65;&#x73;&#x74;&#x6f;&#x72;&#x2e;&#x72;&#x65;&#108;&#97;&#116;&#105;&#111;&#110;&#115;&#64;bms&#46;c&#x6f;&#x6d;<\/a><\/p>\n<p> <a href=\"http:\/\/www.businesswire.com\/news\/home\/20240322953592\/en\/Bristol-Myers-Squibb-to-Present-Data-at-the-American-College-of-Cardiology-Annual-Scientific-Session-2024-Reinforcing-Extensive-Body-of-Evidence-in-Clinical-and-Real-World-Settings-Across-Cardiovascular-Portfolio\/?feedref=Zd8jjkgYuzBwDixoAdXmJgT1albrG1Eq4mAeVP392103_ypKzv-7ah0oHKWbnuHnevRMp3sIgu8q3wq1OF24lT93qbEzrwa15HGbLqMObxZM7XiMhduiSeKMTNDLRqI_doMC3CVAuyHo5cJ7XfDuvA==\"> Read full story here <\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Analysis from a 10-month post-launch evaluation of the REMS Program finds 2.8% incidence of LVEF &lt;50% in over 1500 patients, strengthening the safety profile of CAMZYOS\u00ae (mavacamten) for NYHA class II-III obstructive hypertrophic cardiomyopathy Real-world data reaffirm therapeutic value and treatment benefit of CAMZYOS in improving cardiac symptoms and NYHA class in patients with obstructive &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/bristol-myers-squibb-to-present-data-at-the-american-college-of-cardiology-annual-scientific-session-2024-reinforcing-extensive-body-of-evidence-in-clinical-and-real-world-settings-across-cardiovascul\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-59096","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bristol Myers Squibb to Present Data at the American College of Cardiology Annual Scientific Session 2024 Reinforcing Extensive Body of Evidence in Clinical and Real-World Settings Across Cardiovascular Portfolio - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/bristol-myers-squibb-to-present-data-at-the-american-college-of-cardiology-annual-scientific-session-2024-reinforcing-extensive-body-of-evidence-in-clinical-and-real-world-settings-across-cardiovascul\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bristol Myers Squibb to Present Data at the American College of Cardiology Annual Scientific Session 2024 Reinforcing Extensive Body of Evidence in Clinical and Real-World Settings Across Cardiovascular Portfolio - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Analysis from a 10-month post-launch evaluation of the REMS Program finds 2.8% incidence of LVEF &lt;50% in over 1500 patients, strengthening the safety profile of CAMZYOS\u00ae (mavacamten) for NYHA class II-III obstructive hypertrophic cardiomyopathy Real-world data reaffirm therapeutic value and treatment benefit of CAMZYOS in improving cardiac symptoms and NYHA class in patients with obstructive ... 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