{"id":60836,"date":"2025-02-25T01:02:37","date_gmt":"2025-02-25T00:02:37","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/seraph-100-blood-filtration-media-may-reduce-tumor-associated-particles-in-blood-samples-drawn-from-pancreatic-cancer-patients\/"},"modified":"2025-02-25T01:02:37","modified_gmt":"2025-02-25T00:02:37","slug":"seraph-100-blood-filtration-media-may-reduce-tumor-associated-particles-in-blood-samples-drawn-from-pancreatic-cancer-patients","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/seraph-100-blood-filtration-media-may-reduce-tumor-associated-particles-in-blood-samples-drawn-from-pancreatic-cancer-patients\/","title":{"rendered":"Seraph 100 Blood Filtration Media May Reduce Tumor-Associated Particles in Blood Samples Drawn From Pancreatic Cancer Patients"},"content":{"rendered":"
\n

\nNew Laboratory Study Highlights Novel Approach to Disease Management Under Development<\/i><\/p>\n

MARTINEZ, Calif.–(BUSINESS WIRE)–A new laboratory study has provided insights into the potential therapeutic benefits of blood purification for patients with metastatic pancreatic ductal adenocarcinoma (PDAC), one of the deadliest forms of cancer. Researchers have demonstrated that ExThera Medical\u2019s Seraph\u00ae <\/sup>100 Microbind \u00ae<\/sup> Affinity Blood Filter (Seraph 100) adsorption media selectively removes specific tumor-associated microparticles from the blood of PDAC patients, offering the potential for a novel approach to disease management.<\/p>\n

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\nPrevious in vitro<\/i> studies have shown that the concentration of circulating tumor cells (CTCs) can be reduced through the use of Seraph 100 filter media. This latest study from a collaboration between Cedars- Sinai Medical Center, University of Southern California, and the Keck School of Medicine, which analyzed blood samples from seven PDAC patients, extends the findings by evaluating the impact of blood purification on additional<\/i> tumorigenic factors, including microparticles and soluble proteins.<\/p>\n

\n\u201cAlthough more clinical research is needed, these findings increase our understanding as we investigate a promising new approach for treating metastatic disease, which remains one of the most challenging and deadly forms of cancer,\u201d said ExThera Medical Chairman and Founder Bob Ward, NAE.<\/p>\n

\nThe Seraph 100 is a broad-spectrum sorbent extracorporeal hemoperfusion filter initially developed for reduction of pathogens from the bloodstream inclusive of bacteria, viruses, and fungi. In vitro<\/i> experiments<\/a> previously demonstrated that Seraph 100 adsorption media is capable of removing CTCs from blood. The Seraph 100 now has nearly 70 peer-reviewed publications and print mentions. ExThera Medical remains committed to generating robust clinical data to evaluate the safety and efficacy of the Seraph 100 across multiple applications.<\/p>\n

\nThe results of the study were published in ScienceDirect\u2019s Cancer Letters<\/i><\/a>.<\/p>\n

\nShishido SN, Suresh D et al. Determining the efficacy of ExThera Seraph100 blood filtration in patients diagnosed with pancreatic cancer through the liquid biopsy. BJC Rep 2, 47 (2024). doi: 10.1038\/s44276-024-00069-3.<\/p>\n

\nWaldron R, Wang R, Shishido S et al. Selective removal of proteins and microvesicles ex vivo from blood of pancreatic cancer patients using bioengineered adsorption filters. Cancer Letters, 2025; 614:217546. doi: 10.1016\/j.canlet.2025.217546.<\/p>\n

\nAbout ExThera Medical Corporation<\/b><\/p>\n

\nExThera Medical Corporation develops and commercializes extracorporeal blood filtration devices, including the Seraph\u00ae<\/sup> 100 Microbind\u00ae <\/sup>Affinity Blood Filter (Seraph 100) for removing a broad range of pathogens from the bloodstream of patients. Seraph 100 can be used in hospitals, clinics, on battlefields and in other austere environments to address nosocomial and community-acquired infections as well as those caused by battlefield wounds, pandemics, and biological warfare agents. ExThera Medical\u2019s extracorporeal products have demonstrated life-saving capabilities in a wide range of critically ill patients suffering from sepsis, COVID-19, and many other severe bloodstream infections. With a growing body of outcome and health economic evidence from independent clinical studies, success in the DARPA Dialysis-Like Therapeutics program, and from successful clinical use in the U.S., the EU, and the Middle East, the company is well positioned to serve healthcare professionals and patients alike.<\/p>\n

\nThe Seraph <\/sup>100 device has neither been cleared nor approved by the U.S. Food and Drug Administration (FDA) for any indication. The Seraph 100 has been authorized by FDA under an Emergency Use Authorization (EUA) to treat patients with COVID-19 infection. The Seraph 100 is authorized only for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of the Seraph 100 device under section 564(b)(1) of the Act, 21 U.S.C. \u00a7 360bbb-3(b)(1), unless the authorization is terminated or revoked sooner.<\/p>\n

\nFor more information, visit the company\u2019s website at http:\/\/www.extheramedical.com\/<\/a>.<\/p>\n

\nAbout Seraph 100 and the ONCObind Procedure<\/b><\/p>\n

\nAs a patient\u2019s blood flows through the Seraph\u00ae<\/sup> 100 Microbind\u00ae<\/sup> Affinity Filter (Seraph 100), it passes through a bed of small beads with receptors that mimic the receptors on human cells that pathogens target when they invade the body. Many harmful substances are quickly captured and adsorbed onto the surface of the beads and are thereby subtracted from the bloodstream. Seraph 100 adds nothing to the bloodstream. It targets the pathogens that cause the infection, while it also binds and removes harmful substances generated by the pathogen and by the body\u2019s response to the infection. Seraph\u2019s proprietary adsorption media (the beads) constitute a flexible platform that uses immobilized (chemically bonded) heparin for its well-established blood compatibility and its unique ability to bind circulating tumor cells, bacteria, viruses, fungi, and important sepsis mediators reported to contribute to organ failure during sepsis.<\/p>\n

\nExThera Medical is currently developing the ONCObind Procedure Hemoperfusion Filter (ONCObind) to support cancer treatment. ONCObind is part of the same platform technology as Seraph 100.<\/p>\n

\nFor more news stories on Seraph 100 and ONCObind, click here<\/a>.<\/p>\n

\nDisclaimer<\/b><\/p>\n

\nAll information contained in this news release derives from plausible, reliable sources, however they have not been independently examined or verified. There is no representation, warranty, or guarantee provided herein. Except as otherwise required by appliable law, all liability for any direct or indirect claims, damages or losses are hereby disclaimed whether or not foreseeable. This communication includes forward-looking statements regarding events, trends and business prospects that may affect our future operating results and financial position. Such statements are subject to risks and uncertainties that could cause our actual results and financial position to differ materially. Accordingly, the investment and\/or the revenues that arise from it can rise or fall or fail entirely. We assume no responsibility to update or revise any statements contained in this news release, including forward-looking, to reflect events, trends, or circumstances that might arise after the date of this news release. Results from case studies (reviews) may not be predictive of future results.<\/p>\n

Contacts<\/b> <\/p>\n

\nStephanie Connolly
\n
media@extheramedical.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

New Laboratory Study Highlights Novel Approach to Disease Management Under Development MARTINEZ, Calif.–(BUSINESS WIRE)–A new laboratory study has provided insights into the potential therapeutic benefits of blood purification for patients with metastatic pancreatic ductal adenocarcinoma (PDAC), one of the deadliest forms of cancer. Researchers have demonstrated that ExThera Medical\u2019s Seraph\u00ae 100 Microbind \u00ae Affinity Blood … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-60836","6":"format-standard","7":"category-industry"},"yoast_head":"\nSeraph 100 Blood Filtration Media May Reduce Tumor-Associated Particles in Blood Samples Drawn From Pancreatic Cancer Patients - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/seraph-100-blood-filtration-media-may-reduce-tumor-associated-particles-in-blood-samples-drawn-from-pancreatic-cancer-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Seraph 100 Blood Filtration Media May Reduce Tumor-Associated Particles in Blood Samples Drawn From Pancreatic Cancer Patients - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"New Laboratory Study Highlights Novel Approach to Disease Management Under Development MARTINEZ, Calif.–(BUSINESS WIRE)–A new laboratory study has provided insights into the potential therapeutic benefits of blood purification for patients with metastatic pancreatic ductal adenocarcinoma (PDAC), one of the deadliest forms of cancer. Researchers have demonstrated that ExThera Medical\u2019s Seraph\u00ae 100 Microbind \u00ae Affinity Blood ... 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