{"id":61142,"date":"2025-04-24T10:06:23","date_gmt":"2025-04-24T08:06:23","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/mosaic-therapeutics-in-licenses-two-clinical-stage-oncology-programs-from-astex-pharmaceuticals-for-development-as-proprietary-combination-therapies\/"},"modified":"2025-04-24T10:06:23","modified_gmt":"2025-04-24T08:06:23","slug":"mosaic-therapeutics-in-licenses-two-clinical-stage-oncology-programs-from-astex-pharmaceuticals-for-development-as-proprietary-combination-therapies","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/mosaic-therapeutics-in-licenses-two-clinical-stage-oncology-programs-from-astex-pharmaceuticals-for-development-as-proprietary-combination-therapies\/","title":{"rendered":"Mosaic Therapeutics In-Licenses Two Clinical-Stage Oncology Programs From Astex Pharmaceuticals for Development as Proprietary Combination Therapies"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\n<i>In-licensing transforms Mosaic from a research and platform company to a clinical-stage oncology business<\/i>\n<\/li>\n<li>\n<i>Mosaic will develop proprietary, targeted combination products, supported by proprietary biomarkers, to realise the full potential of the assets<\/i>\n<\/li>\n<li>\n<i>As part of the agreement Astex has taken an equity stake in Mosaic<\/i>\n<\/li>\n<\/ul>\n<p>CAMBRIDGE, England&#8211;(BUSINESS WIRE)&#8211;Mosaic Therapeutics, Ltd (\u2018Mosaic\u2019, or \u2018the Company\u2019) a targeted oncology therapeutics company dedicated to resolving cancer\u2019s complexity with new combination therapies for patients, today announces the in-licensing of two clinical-stage oncology programs from Astex Pharmaceuticals (\u2018Astex\u2019), a wholly owned subsidiary of Otsuka Pharmaceutical Co. Ltd. Mosaic has identified proprietary combinations incorporating the licensed products and their targets and this agreement gives Mosaic the exclusive rights to develop those combination products for patients for whom there are no, or limited, treatment options.\n<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20250423222275\/en\/2448125\/5\/Mosaic_New_Logo_For_BusinessWire.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20250423222275\/en\/2448125\/22\/Mosaic_New_Logo_For_BusinessWire.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20250423222275\/en\/2448125\/5\/Mosaic_New_Logo_For_BusinessWire.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20250423222275\/en\/2448125\/21\/Mosaic_New_Logo_For_BusinessWire.jpg\"><\/a><\/p>\n<p>\nAs part of the agreement, Astex has taken an equity stake in Mosaic equating to a fully-diluted ownership stake of 19% equity upfront and a further 3% dependent on clinical milestones, which will consolidate the partnership between these two innovation-driven businesses. Astex will also receive potential future revenue shares. Dr. Harren Jhoti, co-founder, president and chief executive officer of Astex, will also take an observer role on the Mosaic Board. Other financial details have not been disclosed.\n<\/p>\n<p>\nMosaic\u2019s platform identifies combinations of pairs of oncology drugs predicted to have synergistic activity in biomarker-defined patient populations and expected to lead to greater efficacy and durability of response than achieved as monotherapy. The development strategy for each combination product is to seek a broad, biomarker-defined label across multiple tumour types. The two small molecule assets from Astex are ASTX029, an ERK1\/2 inhibitor discovered by Astex that has completed a Phase 2 clinical study and ASTX295 an MDM2 antagonist discovered by Astex in collaboration with the Cancer Research UK Drug Discovery Unit at Newcastle University, that has completed a Phase 1 clinical study. Each of the two licensed compounds has been studied in more than 100 patients and demonstrated differentiated safety profiles within their target class and single-agent activity as monotherapies, enabling use in combination therapies.\n<\/p>\n<p>\n\u201c<i>Mosaic\u2019s mission is to bring novel targeted combination medicines to patients who need them<\/i>,\u201d said <b>Dr. Edward Hodgkin, Managing Partner of Syncona Investment Management Limited and Chair of Mosaic<\/b>. \u201c<i>The in licensing of these two clinical-stage assets provides a step change in our development pipeline, allowing Mosaic to progress targeted drug combinations in novel biomarker-defined settings and enabling the delivery of precision medicines for patients who currently have few therapeutic options. Excitingly the deal significantly accelerates Mosaic\u2019s development path, with the first clinical combination study expected to commence in 2026<\/i>.\u201d\n<\/p>\n<p>\n\u201c<i>We recognise the significance of Mosaic\u2019s platform, which has identified these two assets as anchor components of a pipeline of potential combination products<\/i>,\u201d <b>said Dr. Harren Jhoti, co-founder, president and chief executive officer of Astex. <\/b>\u201c<i>Both drug targets are well-characterised drivers of many cancers, and we are excited to be working with the experienced team at Mosaic to expand the Company\u2019s pipeline in combination therapies with high unmet medical need<\/i>.\u201d\n<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\nKatie Odgaard<br \/>\n<br \/>E: <a target=\"_blank\" href=\"&#109;&#x61;i&#x6c;&#x74;&#111;&#x3a;k&#97;&#x74;&#105;&#x65;&#46;&#111;&#x64;g&#x61;a&#114;&#x64;&#64;&#x7a;&#x79;&#109;&#x65;c&#111;&#x6d;&#109;&#x75;n&#105;&#x63;&#97;&#x74;i&#111;&#x6e;s&#x2e;&#x63;&#111;&#x6d;\" rel=\"nofollow\" shape=\"rect\">&#107;&#97;&#x74;&#x69;&#101;&#46;&#x6f;&#x64;&#103;&#97;&#x61;&#x72;&#100;&#64;&#x7a;&#x79;&#109;&#101;&#x63;&#x6f;&#109;&#109;&#x75;&#x6e;&#105;&#99;&#x61;&#x74;&#105;&#111;&#x6e;&#x73;&#46;&#99;&#x6f;&#x6d;<\/a><br \/>T: +44 (0)7787 502 947\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>In-licensing transforms Mosaic from a research and platform company to a clinical-stage oncology business Mosaic will develop proprietary, targeted combination products, supported by proprietary biomarkers, to realise the full potential of the assets As part of the agreement Astex has taken an equity stake in Mosaic CAMBRIDGE, England&#8211;(BUSINESS WIRE)&#8211;Mosaic Therapeutics, Ltd (\u2018Mosaic\u2019, or \u2018the Company\u2019) &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/mosaic-therapeutics-in-licenses-two-clinical-stage-oncology-programs-from-astex-pharmaceuticals-for-development-as-proprietary-combination-therapies\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-61142","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mosaic Therapeutics In-Licenses Two Clinical-Stage Oncology Programs From Astex Pharmaceuticals for Development as Proprietary Combination Therapies - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/mosaic-therapeutics-in-licenses-two-clinical-stage-oncology-programs-from-astex-pharmaceuticals-for-development-as-proprietary-combination-therapies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mosaic Therapeutics In-Licenses Two Clinical-Stage Oncology Programs From Astex Pharmaceuticals for Development as Proprietary Combination Therapies - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"In-licensing transforms Mosaic from a research and platform company to a clinical-stage oncology business Mosaic will develop proprietary, targeted combination products, supported by proprietary biomarkers, to realise the full potential of the assets As part of the agreement Astex has taken an equity stake in Mosaic CAMBRIDGE, England&#8211;(BUSINESS WIRE)&#8211;Mosaic Therapeutics, Ltd (\u2018Mosaic\u2019, or \u2018the Company\u2019) ... 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