{"id":61293,"date":"2025-05-20T22:02:22","date_gmt":"2025-05-20T20:02:22","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/ccm-biosciences-announces-presentation-of-data-on-its-first-in-class-nsclc-drug-program-at-asco-2025\/"},"modified":"2025-05-20T22:02:22","modified_gmt":"2025-05-20T20:02:22","slug":"ccm-biosciences-announces-presentation-of-data-on-its-first-in-class-nsclc-drug-program-at-asco-2025","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/ccm-biosciences-announces-presentation-of-data-on-its-first-in-class-nsclc-drug-program-at-asco-2025\/","title":{"rendered":"CCM Biosciences Announces Presentation of Data on its First-In-Class NSCLC Drug Program at ASCO 2025"},"content":{"rendered":"
\n

\nCompany\u2019s NSCLC drug program is focused on overcoming both mutational and non-mutational resistance to 3rd<\/sup>-generation EGFR inhibitors and outperforms other investigational 4th<\/sup>-generation inhibitors in a wide range of drug resistance models.<\/i>\n<\/p>\n

<\/a>
<\/a><\/p>\n

MOUNT LAUREL, N.J.–(BUSINESS WIRE)–CCM Biosciences<\/b><\/a>, a diversified pharmaceutical discovery and development company, today announced the upcoming presentation of its 4th-generation EGFR inhibitor drug program for non-small cell lung cancer (NSCLC) at the 2025 Annual Conference of the American Society of Clinical Oncology (ASCO), taking place May 30 to June 3 in Chicago.\n<\/p>\n

\nNSCLC, which accounts for 80% of lung cancer, is the most common cause of cancer death worldwide. Epidermal growth factor receptor (EGFR)-activating mutations (Del19 or L858R) are major oncogenic drivers of NSCLC. EGFR-positive NSCLC accounts for approximately 30% of all diagnosed cases of NSCLC (a similar market size to PD-L1-positive NSCLC, which is addressed by the world\u2019s top-selling drug, Keytruda\u00ae). The current standard of care for EGFR-positive NSCLC is comprised of 3rd<\/sup>-generation inhibitors, most notably Osimertinib (Tagrisso\u00ae), whose annual sales exceed $6 billion. Most patients treated by tyrosine kinase inhibitors (TKIs) will eventually develop resistance mutations including the T790M gatekeeper mutation. Osimertinib, a 3rd-generation covalent TKI, is efficacious against the T790M resistance mutation and prevents its onset if administered as first line therapy. However, treatment with Osimertinib inevitably induces additional mutations, especially the C797S mutation, as well as various off-target resistance mechanisms. To date, there are no approved therapies capable of overcoming mutational or non-mutational resistance to 3rd-generation TKIs. As such, there is an urgent unmet medical need to develop next-generation EGFR inhibitors that overcome these forms of resistance. While billions of dollars have been invested over the last several years on the development of 4th<\/sup>-generation EGFR inhibitors that overcome tumor resistance to 3rd<\/sup>-generation inhibitors, due to the diversity of resistance mechanisms, these inhibitors have failed to progress beyond early-stage clinical trials.\n<\/p>\n

\nAt ASCO 2025, CCM Biosciences\u2019 presentation \u201cNovel, potent and selective fourth-generation inhibitors targeting EGFR for NSCLC therapy\u201d in the Lung Cancer \u2013 Non-small cell \u2013 Metastatic <\/i>session (Abstract #: 8622, https:\/\/www.asco.org\/abstracts-presentations\/ABSTRACT495872<\/a>) will report novel 4th<\/sup>-generation, orally bioavailable EGFR inhibitors (CCM-205, CCM-245 and CCM-308) that can overcome both on-target and off-target resistance in lung cancer models, significantly outperforming the aforementioned 4th<\/sup>-generation inhibitors in the face of resistance to 3rd<\/sup>-generation inhibitors, and have significant potential clinical applications. In addition to their potent activity as monotherapies, CCM-205 and CCM-245 are highly efficacious in combination with 3rd<\/sup>-generation EGFR inhibitors as well as anti-EGFR antibodies, neither of which can maintain or regress tumor volume in the presence of resistance as monotherapies.\n<\/p>\n

\nCCM Biosciences is advancing clinical candidates from its EGFR inhibitor program to investigational new drug (IND) filing this year for entry to clinical trials. The company is actively partnering with biotechnology and pharmaceutical companies for co-development rights in selected countries. CCM Biosciences, a sister company of the global chemical and pharmaceutical services company PMC Group, Inc., is also a Featured Exhibitor at ASCO 2025 — https:\/\/asco25.myexpoonline.com\/co\/ccm-biosciences<\/a> — and will be showcasing both its drug programs and the state-of-the-art platforms used to discover and develop them.\n<\/p>\n

\nAbout CCM Biosciences<\/b>\n<\/p>\n

\nCCM Biosciences is a diversified biotechnology company dedicated to discovering and developing novel drugs, including small molecules, gene therapies, biologics, and nanomedicines within multiple corporate subsidiaries. CCM’s patented drug discovery platforms were developed at Chakrabarti Advanced Technology<\/b><\/a>, a privately funded R&D institute founded in 2010 with scientists in the US, France and India and with publications in leading scientific journals including PNAS, Nucleic Acids Research, Physical Review, American Chemical Society journals, Biophysical Society journals and Nature Publishing Group journals. These platforms are complemented by the contract research, development, and manufacturing organizations (CRDMO) at PMC Group<\/b><\/a>, the sister company of CCM Biosciences and a global chemical and pharmaceutical company with ~$1 billion in annual revenue, enabling fully integrated drug discovery and development.\n<\/p>\n

Contacts<\/b> <\/p>\n

\nAnisha Ghosh<\/b>
anisha@ccm-bio.com<\/a><\/b>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Company\u2019s NSCLC drug program is focused on overcoming both mutational and non-mutational resistance to 3rd-generation EGFR inhibitors and outperforms other investigational 4th-generation inhibitors in a wide range of drug resistance models. MOUNT LAUREL, N.J.–(BUSINESS WIRE)–CCM Biosciences, a diversified pharmaceutical discovery and development company, today announced the upcoming presentation of its 4th-generation EGFR inhibitor drug program … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-61293","6":"format-standard","7":"category-industry"},"yoast_head":"\nCCM Biosciences Announces Presentation of Data on its First-In-Class NSCLC Drug Program at ASCO 2025 - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/ccm-biosciences-announces-presentation-of-data-on-its-first-in-class-nsclc-drug-program-at-asco-2025\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CCM Biosciences Announces Presentation of Data on its First-In-Class NSCLC Drug Program at ASCO 2025 - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Company\u2019s NSCLC drug program is focused on overcoming both mutational and non-mutational resistance to 3rd-generation EGFR inhibitors and outperforms other investigational 4th-generation inhibitors in a wide range of drug resistance models. MOUNT LAUREL, N.J.–(BUSINESS WIRE)–CCM Biosciences, a diversified pharmaceutical discovery and development company, today announced the upcoming presentation of its 4th-generation EGFR inhibitor drug program ... 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