{"id":61413,"date":"2025-06-12T13:02:29","date_gmt":"2025-06-12T11:02:29","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/bristol-myers-squibb-presents-data-across-targeted-protein-degradation-research-including-celmod-agents-and-bcl6-ligand-directed-degrader-at-eha-2025\/"},"modified":"2025-06-12T13:02:29","modified_gmt":"2025-06-12T11:02:29","slug":"bristol-myers-squibb-presents-data-across-targeted-protein-degradation-research-including-celmod-agents-and-bcl6-ligand-directed-degrader-at-eha-2025","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/bristol-myers-squibb-presents-data-across-targeted-protein-degradation-research-including-celmod-agents-and-bcl6-ligand-directed-degrader-at-eha-2025\/","title":{"rendered":"Bristol Myers Squibb Presents Data Across Targeted Protein Degradation Research Including CELMoD\u2122 Agents and BCL6 Ligand-Directed Degrader at EHA 2025"},"content":{"rendered":"<div>\n<p class=\"bwalignc\">\n<b><i>Innovative Agents Highlight Growth of Targeted Protein Degradation Platform and BMS&#8217; Leadership in Innovative Cancer Therapies<\/i><\/b><\/p>\n<p>PRINCETON, N.J.&#8211;(BUSINESS WIRE)&#8211;<a href=\"https:\/\/twitter.com\/search?q=%24BMY&amp;src=ctag\" target=\"_blank\">$BMY<\/a> <a href=\"https:\/\/twitter.com\/hashtag\/BMS?src=hash\" target=\"_blank\">#BMS<\/a>&#8212;<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.bms.com%2F&amp;esheet=54272918&amp;newsitemid=20250612347504&amp;lan=en-US&amp;anchor=Bristol+Myers+Squibb&amp;index=1&amp;md5=d564e2f69d9f1c2ea34e8ca51e3ad252\" rel=\"nofollow\" shape=\"rect\">Bristol Myers Squibb<\/a> (NYSE: BMY) today announced the presentation of new data from its targeted protein degradation platform during the 2025 European Hematology Association (EHA) Annual Congress being held from June 12-15 in Milan, Italy. Presentations feature updated clinical findings on the company\u2019s investigational oral CELMoD\u2122 agents mezigdomide and iberdomide in multiple myeloma, and golcadomide in non-Hodgkin lymphoma, as well as the first results evaluating the company\u2019s first-in-class, oral BCL6 ligand-directed degrader (LDD) (BMS-986458) in non-Hodgkin lymphoma.<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20250612347504\/en\/2495933\/5\/BMS_Logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20250612347504\/en\/2495933\/22\/BMS_Logo.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20250612347504\/en\/2495933\/5\/BMS_Logo.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20250612347504\/en\/2495933\/21\/BMS_Logo.jpg\"><\/a><\/p>\n<p>\nThe latest data presented for the three lead CELMoD agents and BCL6 LDD underscore the potential impact that these therapies may have in addressing significant unmet medical needs in hematologic malignancies. These agents are part of continuing research across targeted protein degradation at Bristol Myers Squibb, which also encompasses additional CELMoD agents, LDDs and degrader antibody conjugates (DACs) across blood cancers and solid tumors, as well as non-malignant hematologic disorders.<\/p>\n<p>\nProtein degraders, like CELMoD agents and LDDs, are therapies designed to target and degrade specific proteins that drive diseases, including many proteins that are difficult to target through conventional small-molecule inhibitors. These innovative agents have the possibility to enhance the efficacy of existing therapies and overcome resistance in various malignancies, potentially improving patient outcomes.<\/p>\n<p>\n\u201cAs a leader in the field of targeted protein degradation, we are committed to applying our decades of expertise to the development of these next wave of agents. The efficacy and safety data presented at the EHA Annual Meeting this year is promising and reinforces the potential of CELMoD agents in combination with other standard treatments,\u201d said Anne Kerber, Senior Vice President, Head of Development, Hematology, Oncology and Cell Therapy for Bristol Myers Squibb. \u201cThese analyses also add to the body of evidence for these programs as we continue pivotal studies for each of the agents that we anticipate reading out in the next year and onwards.\u201d<\/p>\n<p>\n<b><i>Key targeted protein degradation data being presented by Bristol Myers Squibb at the EHA Annual Congress include:<\/i><\/b><\/p>\n<p>\n<b><span class=\"bwuline\">Mezigdomide (MEZI):<\/span><\/b><\/p>\n<p>\n<b>Abstract #4160130<\/b>: Updated results were presented from the dose-escalation phase of the MM-002 study for the combinations of mezigdomide, dexamethasone, and bortezomib (Cohort A MeziVd; n=28), and mezigdomide, dexamethasone, and carfilzomib (Cohort C MeziKd; n=27) in patients with relapsed\/refractory multiple myeloma (RRMM) who had received 2\u20134 prior therapies:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nOverall response rate (ORR) was 75.0% for Cohort A and 85.2% for Cohort C, respectively.<\/li>\n<li>\nMedian (95% CI) duration of response (DOR) for Cohort A and Cohort C was 10.9 (8.8\u201318.7) and 11.9 (6.4\u201335.9) months, respectively.<\/li>\n<li>\nMedian (95% CI) progression-free survival (PFS) for Cohort A and Cohort C was 12.3 and 13.5 months, respectively.<\/li>\n<\/ul>\n<p>\nResults from the dose-expansion cohort (Cohort D) of the study were also presented for the MeziVd combination (n=49) in patients with RRMM who had received 1\u20133 prior therapies:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nORR was 85.7%<\/li>\n<li>\nMedian (95% CI) DOR was 19.4 months (9.7-NA)<\/li>\n<li>\nMedian PFS (95% CI) was 17.5 months<\/li>\n<\/ul>\n<p>\nThe most common grade 3\/4 treatment-emergent adverse event (TEAE) across arms was neutropenia and was managed with G-CSF and dose modifications.<\/p>\n<p>\n<b>Abstract #4160802<\/b>: New data was presented evaluating mezigdomide in all-oral triplet combinations with other oral novel agents in RRMM.<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nResults showed that the ORR was:<\/p>\n<ul class=\"bwlistcircle\">\n<li>\n50% for mezigdomide plus EZH2 inhibitor tazemetostat and dexamethasone (n=16)<\/li>\n<li>\n35% for mezigdomide plus BET inhibitor BMS-986158 and dexamethasone (n=20)<\/li>\n<li>\n80% for mezigdomide plus MEK inhibitor trametinib and dexamethasone (n=20)<\/li>\n<\/ul>\n<\/li>\n<li>\nThe most frequent grade 3\/4 TEAE was neutropenia, and grade 3\/4 nonhematologic TEAEs were low.<\/li>\n<li>\nA separate analysis <b>(Abstract #4160749) <\/b>showed that these combinations lead to the activation and proliferation of NK and T cells, including in patients previously treated with T cell-redirecting therapies.<\/li>\n<\/ul>\n<p>\n<b><span class=\"bwuline\">Iberdomide (IBER):<\/span><\/b><\/p>\n<p>\n<b>Abstract #4160144<\/b>: Updated results were presented from MM-001, evaluating the combination of iberdomide, bortezomib, and dexamethasone (IberVd) in patients with transplant-ineligible, newly diagnosed multiple myeloma (NDMM), confirming durable, deep responses in the study.<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nAt a median follow-up of 25 months, the ORR in the intent-to-treat (ITT) population (n=18) was 88.9%, with 66.6% having a complete response or better.<\/li>\n<li>\n44% of patients in CR achieved minimal residual disease (MRD) negativity at a sensitivity of 10<sup>-5<\/sup>.<\/li>\n<li>\nThe most common hematologic grade 3\/4 TEAE was neutropenia (29.4%); 2 (11.8%) patients had grade 3\/4 peripheral neuropathy. Overall, the most common grade 3\/4 TEAEs were infections (47.1%).<\/li>\n<\/ul>\n<p>\n<b><span class=\"bwuline\">Golcadomide (GOLCA):<\/span><\/b><\/p>\n<p>\n<b>Abstract #4160953<\/b>: Updated results were presented from a study evaluating golcadomide with or without rituximab for the treatment of R\/R follicular lymphoma (FL). Patients with R\/R FL who had received \u22652 prior lines of treatment received golcadomide monotherapy in the dose-escalation part of the study (Part A), followed by golcadomide once daily at 0.2 or 0.4 mg with or without rituximab in the expansion part (Part B). Results continued to show promising efficacy with durable responses in heavily pre-treated patients with R\/R FL.<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nIn Part A, the ORR was 67%, with a complete response rate (CRR) of 42% for patients treated with golcadomide monotherapy.<\/li>\n<li>\nIn Part B, the ORR was 94% and the CRR was 63% for patients treated with golcadomide 0.4mg + rituximab. The median DOR was 4.8 months at a median follow-up of 5.75 months. Responses were consistent in patients who received prior lenalidomide-based and\/or T cell-redirecting therapy.<\/li>\n<li>\nThe most common grade 3\/4 treatment-related adverse events across dose levels in Part B (n=60) were neutropenia and anemia, occurring in 60% and 13% of patients, respectively. No patients discontinued therapy due to side effects related to golcadomide. Non-hematologic side effects were infrequent and mostly low-grade.<\/li>\n<\/ul>\n<p>\n<b>Abstract #4161005<\/b>: Updated results were presented from a study evaluating golcadomide with or without rituximab for the treatment of R\/R diffuse large b-cell lymphoma (DLBCL). Patients received golcadomide once daily at either 0.2 mg (n=39) or 0.4 mg (n=38). Results continued to show durable responses in heavily pre-treated patients with R\/R DLBCL and a consistent safety profile.<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nFor patients treated with golcadomide 0.4mg + rituximab, the ORR was 58% and the CRR was 44%, with a median DOR of 14.5 months. Among patients who had prior T cell\u2013redirecting therapy, the ORR was 56%, and the CRR was 38%.<\/li>\n<li>\nThe most common grade 3\/4 treatment-related adverse events across dose levels (n=77) were neutropenia and anemia, occurring in 64% and 20% of patients, respectively. Most adverse events were manageable, with discontinuation due to AE occurring in 7% of patients.<\/li>\n<\/ul>\n<p>\nBased on the results of early studies, mezigdomide, iberdomide and golcadomide are being evaluated in multiple phase 3 studies:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nSUCCESSOR-1: mezigdomide, bortezomib, and dexamethasone vs. pomalidomide, bortezomib, and dexamethasone in patients with RRMM (projected data in 2026)<\/li>\n<li>\nSUCCESSOR-2: mezigdomide, carfilzomib, and dexamethasone vs. carfilzomib and dexamethasone in patients with RRMM (projected data in 2026)<\/li>\n<li>\nEXCALIBER RRMM: iberdomide, daratumumab, and dexamethasone vs. daratumumab, bortezomib, and dexamethasone in patients with RRMM (projected MRD data in 2025)<\/li>\n<li>\nEXCALIBER Maintenance: iberdomide maintenance vs. lenalidomide maintenance following autologous stem cell transplant in patients with NDMM (projected data in 2029)<\/li>\n<li>\nGOLSEEK-1: golcadomide and R-CHOP chemotherapy vs. placebo and R-CHOP in patients with previously untreated high-risk LBCL (projected data in 2028)<\/li>\n<li>\nGOLSEEK-4: golcadomide and rituximab vs. investigator&#8217;s choice in patients with R\/R FL who received at least 1 prior systemic therapy (projected data in 2030)<\/li>\n<\/ul>\n<p>\n<b><span class=\"bwuline\">BMS-986458 BCL6 LDD:<\/span><\/b><\/p>\n<p>\n<b>Abstract #4160340:<\/b> First clinical findings were presented from the dose-escalation part of the first-in-human, multicenter, open-label study of BMS-986458 in patients with relapsed\/refractory (R\/R) non-Hodgkin lymphoma (NHL). Initial results evaluating 31 heavily pre-treated patients treated with BMS-986458 were promising and support continued development for the treatment of NHL.<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nBMS 986458 was well-tolerated, with the most common treatment-related adverse events (TRAEs) being grade 1\/2 arthralgia (19.4%) and fatigue (16.1%); no grade \u22653 treatment-related cytopenias or treatment-related discontinuations were observed.<\/li>\n<li>\nRapid and sustained degradation of BCL6 was demonstrated in peripheral blood and in the tumor at all doses evaluated.<\/li>\n<li>\nAntitumor activity was evident from the first dose level in DLBCL and FL patients. Among 21 efficacy-evaluable patients, the ORR was 81% (N=17), and CRR was 23.8% (N=5).<\/li>\n<\/ul>\n<p>\n<b><span class=\"bwuline\">Bristol Myers Squibb: Creating a Better Future for People with Cancer<\/span><\/b><\/p>\n<p>\nBristol Myers Squibb is inspired by a single vision \u2014 transforming patients\u2019 lives through science. The goal of the company\u2019s cancer research is to deliver medicines that offer each patient a better, healthier life and to make cure a possibility. Building on a legacy across a broad range of cancers that have changed survival expectations for many, Bristol Myers Squibb researchers are exploring new frontiers in personalized medicine and, through innovative digital platforms, are turning data into insights that sharpen their focus. Deep understanding of causal human biology, cutting-edge capabilities and differentiated research platforms uniquely position the company to approach cancer from every angle.<\/p>\n<p>\nCancer can have a relentless grasp on many parts of a patient\u2019s life, and Bristol Myers Squibb is committed to taking actions to address all aspects of care, from diagnosis to survivorship. As a leader in cancer care, Bristol Myers Squibb is working to empower all people with cancer to have a better future.<\/p>\n<p>\n<b><span class=\"bwuline\">About Bristol Myers Squibb<\/span><\/b><\/p>\n<p>\nBristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. For more information about Bristol Myers Squibb, visit us at <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.bms.com&amp;esheet=54272918&amp;newsitemid=20250612347504&amp;lan=en-US&amp;anchor=BMS.com&amp;index=2&amp;md5=fc8038e8884b252cd647b5d10a30fd71\" rel=\"nofollow\" shape=\"rect\">BMS.com<\/a> or follow us on <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fbristol-myers-squibb&amp;esheet=54272918&amp;newsitemid=20250612347504&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=3&amp;md5=0048254c52994b5987267bb92cd5941f\" rel=\"nofollow\" shape=\"rect\">LinkedIn<\/a>, <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2Fbmsnews&amp;esheet=54272918&amp;newsitemid=20250612347504&amp;lan=en-US&amp;anchor=X&amp;index=4&amp;md5=c67fb96bda8fd65b818f102e8389ac76\" rel=\"nofollow\" shape=\"rect\">X<\/a>, <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.youtube.com%2Fchannel%2FUCjFf4oKibYrHae2NZ_GPS6g&amp;esheet=54272918&amp;newsitemid=20250612347504&amp;lan=en-US&amp;anchor=YouTube&amp;index=5&amp;md5=62c1276afc76364597c23c6a7080060e\" rel=\"nofollow\" shape=\"rect\">YouTube<\/a>, <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.facebook.com%2Fbristolmyerssquibb&amp;esheet=54272918&amp;newsitemid=20250612347504&amp;lan=en-US&amp;anchor=Facebook&amp;index=6&amp;md5=129dd4425299d8714f970e6c8027c2a2\" rel=\"nofollow\" shape=\"rect\">Facebook<\/a> and <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.instagram.com%2Fbristolmyerssquibb%2F&amp;esheet=54272918&amp;newsitemid=20250612347504&amp;lan=en-US&amp;anchor=Instagram&amp;index=7&amp;md5=97f066bca6926067227aaef3875f6601\" rel=\"nofollow\" shape=\"rect\">Instagram<\/a>.<\/p>\n<p>\n<b><span class=\"bwuline\">Cautionary Statement Regarding Forward-Looking Statements<\/span><\/b><\/p>\n<p>\n<i>This press release contains &#8220;forward-looking statements&#8221; within the meaning of the Private Securities Litigation Reform Act of 1995 regarding, among other things, the research, development, and commercialization of pharmaceutical products. All statements that are not statements of historical facts are, or may be deemed to be, forward-looking statements. Such forward-looking statements are based on historical performance and current expectations and projections about our future financial results, goals, plans, and objectives and involve inherent risks, assumptions, and uncertainties, including internal or external factors that could delay, divert, or change any of them in the next several years, that are difficult to predict, may be beyond our control, and could cause our future financial results, goals, plans, and objectives to differ materially from those expressed in, or implied by, the statements. These risks, assumptions, uncertainties, and other factors include, among others, that the results of these studies may not be predictive of the results of future studies, that iberdomide, mezigdomide and golcadomide may not receive regulatory approval for the indications described in this release, and if approved, whether such product candidates for such indications described in this release will be commercially successful. No forward-looking statement can be guaranteed. Forward-looking statements in this press release should be evaluated together with the many risks and uncertainties that affect Bristol Myers Squibb&#8217;s business and market, particularly those identified in the cautionary statement and risk factors discussion in Bristol Myers Squibb&#8217;s Annual Report on Form 10-K for the year ended December 31, 2024, as updated by our subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and other filings with the Securities and Exchange Commission. The forward-looking statements included in this document are made only as of the date of this document, and except as otherwise required by applicable law, Bristol Myers Squibb undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, changed circumstances, or otherwise.<\/i><\/p>\n<p>\ncorporatefinancial-news<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Bristol Myers Squibb<\/b><\/p>\n<p>\n<b>Media Inquiries:<\/b><br \/><a target=\"_blank\" href=\"mail&#116;&#111;&#58;&#109;&#101;&#x64;&#x69;&#x61;&#x40;&#x62;&#x6d;&#x73;&#46;com\" rel=\"nofollow\" shape=\"rect\">&#109;&#x65;&#x64;&#105;&#x61;&#x40;&#98;&#x6d;&#x73;&#46;&#x63;&#x6f;&#109;<\/a><\/p>\n<p>\n<b>Investors:<\/b><br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#x69;&#x6c;&#116;&#111;&#58;in&#x76;&#x65;&#x73;&#x74;&#x6f;&#114;&#46;&#114;el&#x61;&#x74;&#x69;&#x6f;&#x6e;&#115;&#64;&#98;ms&#x2e;&#x63;&#x6f;&#x6d;\" rel=\"nofollow\" shape=\"rect\">&#105;&#x6e;&#x76;e&#115;&#x74;&#x6f;r&#46;&#x72;e&#108;&#x61;&#x74;i&#111;&#x6e;s&#64;&#x62;&#x6d;s&#46;&#x63;&#x6f;&#109;<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Innovative Agents Highlight Growth of Targeted Protein Degradation Platform and BMS&#8217; Leadership in Innovative Cancer Therapies PRINCETON, N.J.&#8211;(BUSINESS WIRE)&#8211;$BMY #BMS&#8212;Bristol Myers Squibb (NYSE: BMY) today announced the presentation of new data from its targeted protein degradation platform during the 2025 European Hematology Association (EHA) Annual Congress being held from June 12-15 in Milan, Italy. Presentations &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/bristol-myers-squibb-presents-data-across-targeted-protein-degradation-research-including-celmod-agents-and-bcl6-ligand-directed-degrader-at-eha-2025\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-61413","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Bristol Myers Squibb Presents Data Across Targeted Protein Degradation Research Including CELMoD\u2122 Agents and BCL6 Ligand-Directed Degrader at EHA 2025 - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/bristol-myers-squibb-presents-data-across-targeted-protein-degradation-research-including-celmod-agents-and-bcl6-ligand-directed-degrader-at-eha-2025\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bristol Myers Squibb Presents Data Across Targeted Protein Degradation Research Including CELMoD\u2122 Agents and BCL6 Ligand-Directed Degrader at EHA 2025 - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Innovative Agents Highlight Growth of Targeted Protein Degradation Platform and BMS&#8217; Leadership in Innovative Cancer Therapies PRINCETON, N.J.&#8211;(BUSINESS WIRE)&#8211;$BMY #BMS&#8212;Bristol Myers Squibb (NYSE: BMY) today announced the presentation of new data from its targeted protein degradation platform during the 2025 European Hematology Association (EHA) Annual Congress being held from June 12-15 in Milan, Italy. 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