{"id":61766,"date":"2025-08-25T13:05:32","date_gmt":"2025-08-25T11:05:32","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/merz-therapeutics-announces-first-patients-enrolled-in-two-phase-iii-trials-investigating-xeomin-incobotulinumtoxina-for-migraine-prevention\/"},"modified":"2025-08-25T13:05:32","modified_gmt":"2025-08-25T11:05:32","slug":"merz-therapeutics-announces-first-patients-enrolled-in-two-phase-iii-trials-investigating-xeomin-incobotulinumtoxina-for-migraine-prevention","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/merz-therapeutics-announces-first-patients-enrolled-in-two-phase-iii-trials-investigating-xeomin-incobotulinumtoxina-for-migraine-prevention\/","title":{"rendered":"Merz Therapeutics Announces First Patients Enrolled in Two Phase III Trials Investigating XEOMIN\u00ae (incobotulinumtoxinA) for Migraine Prevention"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\nTrials designed to reflect migraine burden and patient experience<\/li>\n<li>\nMerz Therapeutics continues to build on established neurotoxin expertise<\/li>\n<\/ul>\n<p>FRANKFURT, Germany &amp; RALEIGH, N.C.&#8211;(BUSINESS WIRE)&#8211;Merz Therapeutics GmbH, a leading player in neurology-focused specialty pharma, today announced that the first patients have been enrolled in two global Phase III clinical trials \u2014 MINT-E (<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.clinicaltrials.gov%2Fstudy%2FNCT07018700%3Fintr%3DNCT07018700%2520%26rank%3D1&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=NCT07018700&amp;index=1&amp;md5=8f644f3ab8df2c1698d9faddba778474\" rel=\"nofollow\" shape=\"rect\">NCT07018700<\/a>) and MINT-C (<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.clinicaltrials.gov%2Fstudy%2FNCT07018713%3Fintr%3DNCT07018713%26rank%3D1&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=NCT07018713&amp;index=2&amp;md5=fac985bb32a5b030aa09494213d96273\" rel=\"nofollow\" shape=\"rect\">NCT07018713<\/a>) \u2014 evaluating the efficacy and safety of XEOMIN<sup>\u00ae<\/sup> (incobotulinumtoxinA) for the prevention of episodic and chronic migraine in adults. Migraine affects around 1.1 billion people worldwide, posing a significant burden on patients and healthcare systems.<sup>1<\/sup><\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20250822411240\/en\/2559837\/5\/MERZ_THERAPEUTICS-Logo_VC_horizontal_2000Px.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20250822411240\/en\/2559837\/22\/MERZ_THERAPEUTICS-Logo_VC_horizontal_2000Px.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20250822411240\/en\/2559837\/5\/MERZ_THERAPEUTICS-Logo_VC_horizontal_2000Px.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20250822411240\/en\/2559837\/21\/MERZ_THERAPEUTICS-Logo_VC_horizontal_2000Px.jpg\"><\/a><\/p>\n<p>\n\u201cDespite the availability of multiple treatment options, the need remains for additional options for prevention of migraines,\u201d says Stefan K\u00f6nig, CEO, Merz Therapeutics. \u201cThe enrollment of the first patients in the MINT trials marks an important milestone as we aim to address persistent gaps in migraine care by advancing a new neurotoxin option for patients.\u201d<\/p>\n<p>\nThe trials will enroll approximately 1,770 adult patients across 120 study sites in North America and Europe.<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nMINT-E will include approximately 990 participants with episodic migraine (defined as less than 15 headache days per month, of which six to 14 are migraine days per month)<\/li>\n<li>\nMINT-C will include approximately 780 participants with chronic migraine (defined as more than 15 headache days per month, of which more than eight are migraine days)<\/li>\n<\/ul>\n<p>\nBoth trials will evaluate the change in monthly migraine days from baseline to Month 6 as the primary endpoint. Secondary endpoints include changes in monthly headache days, acute medication days, and migraine frequency during two-week periods at the end of each injection cycle.<\/p>\n<p>\nPatient enrollment is underway, with sites now active across North America. Recruitment in Europe is expected to follow shortly. The trials will proceed in accordance with regulatory guidelines, including those of the U.S. Food and Drug Administration and study readiness milestones.<\/p>\n<p>\n\u201cThese trials were designed with the patient experience at the forefront \u2014 from trial design and eligibility criteria that reflect current migraine patterns to endpoints that capture the full impact of migraine on daily life,\u201d said Stefan Albrecht, Chief Scientific and Medical Officer, Merz Therapeutics. \u201cBy ensuring representation across both episodic and chronic migraine, we aim to generate data that is not only clinically robust but also deeply relevant to the people we hope to serve.\u201d<\/p>\n<p>\n<b>Understanding the Impact of Migraine<\/b><\/p>\n<p>\nMigraine is characterized by recurrent attacks of moderate to severe head pain, often accompanied by nausea, vomiting, and sensitivity to light and sound.<sup>2<\/sup> Attacks can last from four to 72 hours and may be preceded by aura \u2014 visual or sensory disturbances that signal onset.<sup>3 <\/sup>Episodic migraines affect people fewer than 15 days a month, while chronic migraines occur 15 or more days monthly for at least three months, often with more severe, disabling symptoms. Chronic migraine can have a greater impact on daily life and may require more specialized treatment.<sup>4<\/sup><\/p>\n<p>\nBeyond physical symptoms, migraine is associated with significant emotional, cognitive, and social burden. It frequently co-occurs with depression, anxiety, and sleep disorders, and contributes to reduced quality of life, impaired productivity, and increased healthcare utilization.<sup>5<\/sup><\/p>\n<p>\n<b>XEOMIN<sup>\u00ae<\/sup> (incobotulinumtoxinA) IMPORTANT CONSUMER SAFETY INFORMATION<\/b><\/p>\n<p>\n<b>What is XEOMIN?<\/b><\/p>\n<p>\nXEOMIN is a prescription medicine:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nthat is injected into glands that make saliva and is used to treat long-lasting (chronic) drooling (sialorrhea) in adults and in children 2 years of age or older.<\/li>\n<li>\nthat is injected into muscles and used to:<\/p>\n<ul class=\"bwlistcircle\">\n<li>\ntreat increased muscle stiffness in the arm because of upper limb spasticity in adults.<\/li>\n<li>\ntreat increased muscle stiffness in the arm in children 2 to 17 years of age with upper limb spasticity, excluding spasticity caused by cerebral palsy.<\/li>\n<li>\ntreat the abnormal head position and neck pain with cervical dystonia (CD) in adults.<\/li>\n<li>\ntreat abnormal spasm of the eyelids (blepharospasm) in adults.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>\nIt is not known if XEOMIN is safe and effective in children younger than:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\n2 years of age for the treatment of chronic sialorrhea<\/li>\n<li>\n2 years of age for the treatment of upper limb spasticity<\/li>\n<li>\n18 years of age for the treatment of cervical dystonia or blepharospasm<\/li>\n<\/ul>\n<p>\n<b>What is the most important information I should know about XEOMIN?<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>XEOMIN may cause serious side effects that can be life threatening. Problems swallowing, speaking, or breathing<\/b> can happen within hours to weeks after an injection of XEOMIN if the muscles that you use to breathe and swallow become weak. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN.<\/p>\n<ul class=\"bwlistcircle\">\n<li>\nPeople with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN.<\/li>\n<li>\nSwallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN have the highest risk of getting these problems.<\/li>\n<\/ul>\n<\/li>\n<li>\n<b>Spread of toxin effects<\/b>. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.<\/li>\n<\/ul>\n<p>\nThese symptoms can happen hours to weeks after you receive an injection of XEOMIN. These problems could make it unsafe for you to drive a car or do other dangerous activities.<\/p>\n<p>\n<b>Do not take XEOMIN if you:<\/b> are allergic to XEOMIN or any of the ingredients in XEOMIN (botulinum toxin type A, human albumin, and sucrose), had an allergic reaction to any other botulinum toxin product, or have a skin infection at the planned injection site.<\/p>\n<p>\n<b>Before receiving XEOMIN, tell your doctor about all of your medical conditions, including if you:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nhave a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig&#8217;s disease], myasthenia gravis or Lambert-Eaton syndrome)<\/li>\n<li>\nhave had any side effect from any other botulinum toxin in the past<\/li>\n<li>\nhave a breathing problem, such as asthma or emphysema<\/li>\n<li>\nhave a history of swallowing problems or inhaling food or fluid into your lungs (aspiration)<\/li>\n<li>\nhave drooping eyelids<\/li>\n<li>\nhave had eye surgery<\/li>\n<li>\nhave had surgery on your face<\/li>\n<li>\nare pregnant or plan to become pregnant. It is not known if XEOMIN can harm your unborn baby.<\/li>\n<li>\nare breastfeeding or plan to breastfeed. It is not known if XEOMIN passes into breast milk.<\/li>\n<\/ul>\n<p>\nUsing XEOMIN with certain other medicines may cause serious side effects.<b> Do not start any new medicines until you have told your doctor that you have received XEOMIN in the past.<\/b><\/p>\n<p>\n<b>Especially tell your doctor if you:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nhave received any other botulinum toxin product in the last four months<\/li>\n<li>\nhave received injections of botulinum toxin in the past. Be sure your doctor knows exactly which product you received. The dose of XEOMIN may be different from other botulinum toxin products that you have received.<\/li>\n<li>\nhave recently received an antibiotic by injection or inhalation<\/li>\n<li>\ntake muscle relaxants<\/li>\n<li>\ntake an allergy or cold medicine<\/li>\n<li>\ntake a sleep medicine<\/li>\n<\/ul>\n<p>\n<b>What should I avoid while taking XEOMIN?<\/b><\/p>\n<p>\nXEOMIN may cause loss of strength or general muscle weakness, blurred vision, or drooping eyelids within hours to weeks of taking XEOMIN. If this happens, do not drive a car, operate machinery, or do other dangerous activities.<\/p>\n<p>\n<b>What are the possible Side Effects of XEOMIN?<\/b><\/p>\n<p>\n<b>XEOMIN can cause serious side effects including:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\n<b>Injury to the cornea (the clear front surface of the eye) in people treated for blepharospasm. <\/b>People who receive XEOMIN to treat spasm of the eyelid may have reduced blinking that can cause a sore on their cornea or other problems of the cornea. Call your healthcare provider or get medical care right away if you have eye pain or irritation after treatment with XEOMIN.<\/li>\n<li>\n<b>XEOMIN may cause other serious side effects including<\/b> allergic reactions. Symptoms of an allergic reaction to XEOMIN may include: itching, rash, redness, swelling, wheezing, trouble breathing, or dizziness or feeling faint. Tell your doctor or get medical help right away if you get wheezing or trouble breathing, or if you get dizzy or faint.<\/li>\n<\/ul>\n<p>\n<b>The most common side effects of XEOMIN in adults with chronic sialorrhea include:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nneeding to have a tooth pulled (extracted)<\/li>\n<li>\ndry mouth<\/li>\n<li>\ndiarrhea<\/li>\n<li>\nhigh blood pressure<\/li>\n<\/ul>\n<p>\n<b>The most common side effects of XEOMIN in children 2 to 17 years of age with chronic sialorrhea include:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nbronchitis<\/li>\n<li>\nnausea<\/li>\n<li>\nheadache<\/li>\n<li>\nvomiting<\/li>\n<\/ul>\n<p>\n<b>The most common side effects of XEOMIN in adults with upper limb spasticity include:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nseizure<\/li>\n<li>\nnasal congestion, sore throat and runny nose<\/li>\n<li>\ndry mouth<\/li>\n<li>\nupper respiratory infection<\/li>\n<\/ul>\n<p>\n<b>The most common side effects of XEOMIN in children 2 to 17 years of age with upper limb spasticity include:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nnasal congestion, sore throat and runny nose<\/li>\n<li>\nbronchitis<\/li>\n<\/ul>\n<p>\n<b>The most common side effects of XEOMIN in adults with cervical dystonia include:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\ndifficulty swallowing<\/li>\n<li>\nneck pain<\/li>\n<li>\nmuscle weakness<\/li>\n<li>\npain at the injection site<\/li>\n<li>\nmuscle and bone pain<\/li>\n<\/ul>\n<p>\n<b>The most common side effects of XEOMIN in adults with blepharospasm include:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\ndrooping of the eyelid<\/li>\n<li>\ndry eye<\/li>\n<li>\nvision problems<\/li>\n<li>\ndry mouth<\/li>\n<\/ul>\n<p>\n<b>These are not all the possible side effects of XEOMIN.<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nCall your doctor for medical advice about side effects.<\/li>\n<li>\nYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.fda.gov%2Fmedwatch&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=www.fda.gov%2Fmedwatch&amp;index=3&amp;md5=534feb2baaf912b7d5ac64958481c65f\" rel=\"nofollow\" shape=\"rect\">www.fda.gov\/medwatch<\/a> or call 1-800-FDA-1088.<\/li>\n<\/ul>\n<p>\n<b>The risk information provided here is not comprehensive. To learn more:<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nTalk to your health care provider or pharmacist.<\/li>\n<li>\nVisit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.xeomin.com&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=www.xeomin.com&amp;index=4&amp;md5=095ba5c5997e62a6c8c5a214f957e2bd\" rel=\"nofollow\" shape=\"rect\">www.xeomin.com<\/a> to obtain the Full Prescribing Information and Medication Guide<\/li>\n<li>\nCall 1-855-4MERZTX (1-855-463-7989)<\/li>\n<\/ul>\n<p>\n<b>About XEOMIN<sup>\u00ae<\/sup><\/b><\/p>\n<p>\nXEOMIN<sup>\u00ae<\/sup> (incobotulinumtoxinA) is a prescription medicine that is injected into muscles or glands and used to treat adults and pediatric patients with chronic drooling (sialorrhea), adults with eyelid spasm (blepharospasm), adults with cervical dystonia, and adults and pediatric patients with spasticity of the upper limb.<\/p>\n<p>\nXEOMIN<sup>\u00ae<\/sup> is currently approved in more than 80 countries, including US and Canada, for the treatment of various neurological and aesthetic conditions. The use of XEOMIN<sup>\u00ae<\/sup> for migraine prevention, including prevention of episodic and chronic migraine in adults, is not yet approved by regulatory authorities.<\/p>\n<p>\n<b>About Merz Therapeutics<\/b><\/p>\n<p>\nMerz Therapeutics GmbH is dedicated to delivering better outcomes for more patients. With science as its foundation and the patient experience as its focus, the company relentlessly pursues innovative treatments and partnerships to address unmet needs in movement disorders, neurodegenerative conditions, liver disease, and other health conditions that severely impact patients\u2019 quality of life.<\/p>\n<p>\nMerz Therapeutics is headquartered in Frankfurt am Main, Germany, and is active in more than 80 countries. Merz Therapeutics GmbH is part of the Merz Group, a privately held, family-owned company with a 117-year legacy. With passion and purpose, Merz Therapeutics continues to advance care in specialty neurology in ways that benefit both patients and society.<\/p>\n<p>\nPlease visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.merztherapeutics.com&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=www.merztherapeutics.com&amp;index=5&amp;md5=efea483e1df8ca1466650ddd0c880e19\" rel=\"nofollow\" shape=\"rect\">www.merztherapeutics.com<\/a>.<\/p>\n<p>\n<b>References<\/b><\/p>\n<ol class=\"bwlistdecimal\">\n<li>\nCen, J., Wang, Q., Cheng, L., Gao, Q., Wang, H., &amp; Sun, F. (2024, June 7). <i>Global, regional, and national burden and trends of migraine among women of childbearing age from 1990 to 2021: Insights from the Global Burden of Disease Study 2021.<\/i> The Journal of Headache and Pain. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fdoi.org%2F10.1186%2Fs10194-024-01798-z&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=https%3A%2F%2Fdoi.org%2F10.1186%2Fs10194-024-01798-z&amp;index=6&amp;md5=bec1132f1d65c97af8b8034cc9e294ca\" rel=\"nofollow\" shape=\"rect\">https:\/\/doi.org\/10.1186\/s10194-024-01798-z<\/a><\/li>\n<li>\nDong, L., Dong, W., Jin, Y., Zhang, L., &amp; Li, H. (2025). <i>The global burden of migraine: A 30-year trend review and future projections by age, sex, country, and region<\/i>. Pain and Therapy. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fdoi.org%2F10.1007%2Fs40122-024-00690-7&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=https%3A%2F%2Fdoi.org%2F10.1007%2Fs40122-024-00690-7&amp;index=7&amp;md5=5c9e0df485fec6333a771e7f3151e94a\" rel=\"nofollow\" shape=\"rect\">https:\/\/doi.org\/10.1007\/s40122-024-00690-7<\/a><\/li>\n<li>\nGupta, J., &amp; Gaur, S. (2022, August 24). <i>Migraine: An underestimated neurological condition affecting billions. <\/i>Cureus<i>. <\/i><a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fdoi.org%2F10.7759%2Fcureus.28347&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=https%3A%2F%2Fdoi.org%2F10.7759%2Fcureus.28347&amp;index=8&amp;md5=56bb9fcef6f6adb635a24c221988c1e2\" rel=\"nofollow\" shape=\"rect\">https:\/\/doi.org\/10.7759\/cureus.28347<\/a><\/li>\n<li>\n<i>Chronic Migraines vs. Episodic Migraines: Key Differences and Treatments<\/i>, Princeton &amp; Rutgers Neurology, accessed July 18, 2025, <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.psneurology.com%2Fposts%2Fchronic-migraines-vs-episodic-migraines-key-differences-and-treatments%2F&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.psneurology.com%2Fposts%2Fchronic-migraines-vs-episodic-migraines-key-differences-and-treatments%2F&amp;index=9&amp;md5=98b3e5e137420547282952a4ac84b2a4\" rel=\"nofollow\" shape=\"rect\">https:\/\/www.psneurology.com\/posts\/chronic-migraines-vs-episodic-migraines-key-differences-and-treatments\/<\/a><\/li>\n<li>\nL\u00f3pez-Medina, D. C., &amp; Andrade-Romo, A.-D. (2025, March 14). <i>Cognition, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period<\/i>. BMC Neurology. <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fdoi.org%2F10.1186%2Fs12883-025-04122-7&amp;esheet=54311591&amp;newsitemid=20250822411240&amp;lan=en-US&amp;anchor=https%3A%2F%2Fdoi.org%2F10.1186%2Fs12883-025-04122-7&amp;index=10&amp;md5=f3b87f59d1f7981cca9fefb25ea7283f\" rel=\"nofollow\" shape=\"rect\">https:\/\/doi.org\/10.1186\/s12883-025-04122-7<\/a><\/li>\n<\/ol>\n<p>\nThis press release is not intended to offer recommendations, advice, endorsement, guidance or suggestions for administering or otherwise using XEOMIN<sup>\u00ae<\/sup> in any manner inconsistent with its current prescribing information approved by the U.S. Food and Drug Administration.<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>Press Contacts:<br \/>\n<br \/>\n<\/b><br \/><b>International media<\/b><br \/>Merz Therapeutics GmbH<br \/>\n<br \/>Luke Anthony Mircea-Willats<br \/>\n<br \/>Global Communications<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#x69;&#x6c;&#x74;&#x6f;&#x3a;&#x6c;&#x75;&#x6b;&#x65;&#x2e;&#x6d;&#x69;&#x72;&#x63;&#x65;&#x61;&#x77;&#x69;&#x6c;&#x6c;&#x61;&#x74;&#x73;&#x40;&#x6d;&#x65;&#x72;&#x7a;&#x2e;&#x63;&#x68;\" rel=\"nofollow\" shape=\"rect\">&#x6c;&#x75;&#x6b;&#101;&#46;mi&#x72;&#x63;&#x65;&#x61;&#119;&#105;ll&#x61;&#x74;&#x73;&#64;&#109;&#101;rz&#x2e;&#x63;&#x68;<\/a><\/p>\n<p><b>US media<\/b><br \/>Merz Therapeutics<br \/>\n<br \/>Nicole Lovern<br \/>\n<br \/>Corporate Communications<br \/>\n<br \/>6601 Six Forks Road, Suite 400, Raleigh, NC 27615<br \/>\n<br \/>(571) 442-9665<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#97;&#105;&#x6c;&#x74;&#111;&#58;&#x4e;&#x69;&#99;&#111;&#x6c;&#x65;&#46;&#76;&#x6f;&#x76;&#101;&#114;&#x6e;&#x40;&#109;&#101;&#x72;&#x7a;&#46;&#99;&#x6f;&#x6d;\" rel=\"nofollow\" shape=\"rect\">&#78;&#x69;c&#111;&#x6c;e&#x2e;&#x4c;&#111;&#x76;e&#114;&#x6e;&#64;&#109;&#x65;&#114;&#x7a;&#46;&#99;&#x6f;m<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Trials designed to reflect migraine burden and patient experience Merz Therapeutics continues to build on established neurotoxin expertise FRANKFURT, Germany &amp; RALEIGH, N.C.&#8211;(BUSINESS WIRE)&#8211;Merz Therapeutics GmbH, a leading player in neurology-focused specialty pharma, today announced that the first patients have been enrolled in two global Phase III clinical trials \u2014 MINT-E (NCT07018700) and MINT-C (NCT07018713) &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/merz-therapeutics-announces-first-patients-enrolled-in-two-phase-iii-trials-investigating-xeomin-incobotulinumtoxina-for-migraine-prevention\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-61766","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Merz Therapeutics Announces First Patients Enrolled in Two Phase III Trials Investigating XEOMIN\u00ae (incobotulinumtoxinA) for Migraine Prevention - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/merz-therapeutics-announces-first-patients-enrolled-in-two-phase-iii-trials-investigating-xeomin-incobotulinumtoxina-for-migraine-prevention\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Merz Therapeutics Announces First Patients Enrolled in Two Phase III Trials Investigating XEOMIN\u00ae (incobotulinumtoxinA) for Migraine Prevention - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Trials designed to reflect migraine burden and patient experience Merz Therapeutics continues to build on established neurotoxin expertise FRANKFURT, Germany &amp; RALEIGH, N.C.&#8211;(BUSINESS WIRE)&#8211;Merz Therapeutics GmbH, a leading player in neurology-focused specialty pharma, today announced that the first patients have been enrolled in two global Phase III clinical trials \u2014 MINT-E (NCT07018700) and MINT-C (NCT07018713) ... 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