{"id":61812,"date":"2025-09-03T16:05:37","date_gmt":"2025-09-03T14:05:37","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/shriners-childrens-researcher-pioneers-new-method-for-treating-rheumatoid-and-juvenile-arthritis\/"},"modified":"2025-09-03T16:05:37","modified_gmt":"2025-09-03T14:05:37","slug":"shriners-childrens-researcher-pioneers-new-method-for-treating-rheumatoid-and-juvenile-arthritis","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/shriners-childrens-researcher-pioneers-new-method-for-treating-rheumatoid-and-juvenile-arthritis\/","title":{"rendered":"Shriners Children\u2019s Researcher Pioneers New Method for Treating Rheumatoid and Juvenile Arthritis"},"content":{"rendered":"
\n

\nResearch Could Eventually Lead to New Treatment Methods for Cancer or Diabetes<\/i><\/p>\n

ST. LOUIS–(BUSINESS WIRE)–Shriners Children\u2019s researchers have developed a new way to use the body\u2019s natural internal clock to optimize the delivery of medications and increase their effectiveness.<\/p>\n

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\nShriners Children\u2019s St. Louis<\/a> Director of Research Dr. Farshid Guilak recently published findings<\/a> on a revolutionary new method of \u201cchronotherapy,\u201d the administration of drugs based on the body\u2019s circadian rhythm, potentially changing how medicine is delivered for a variety of conditions in the future.<\/p>\n

\n\u201cThis is the first time that the cell\u2019s natural internal clock has been used for controlling drug delivery and it showcases that finding your body\u2019s optimal time for taking medicine can dramatically impact its effectiveness,” said Dr. Guilak.<\/p>\n

\nCircadian rhythm refers to the body’s 24-hour clock, which is regulated by the brain and responds to light. Using a combination of synthetic biology and tissue engineering, Dr. Guilak\u2019s research team developed circadian-based gene circuits, termed \u201cchronogenetics,\u201d that can be programmed into stem cells that, once implanted in the body, align with a patient\u2019s natural circadian rhythm and deliver anti-inflammatory drugs daily at a prescribed time.<\/p>\n

\n\u201cEvery cell in our body is on a 24-hour cycle, including cells that can carry flares of inflammation that often accompany conditions like rheumatoid and juvenile arthritis,\u201d said Dr. Guilak. \u201cPatients who have arthritis pain often experience their peak symptoms in the early mornings, around 3 a.m. to 5 a.m., which isn\u2019t an ideal time for a child to take medicine. The bioengineered stem cells we\u2019ve created will automatically release the drugs timed to when your body needs them so we can stop inflammation flares even before they happen.\u201d<\/p>\n

\nDr. Guilak said his team\u2019s research has shown that timing the application of medicine to line up with the body\u2019s circadian rhythm can not only help relieve pain but, in some cases, change the course of the disease. He said the findings could eventually be utilized to treat other health conditions, such as cancer or diabetes.<\/p>\n

\n\u201cFor diseases like juvenile arthritis, which can be very painful for children, the sooner you treat the condition, the more you can prevent inflammation that damages the joints,\u201d said Dr. Guilak. \u201cIf the body can receive medication ahead of those flare-ups that therefore prevents joint damage, then the disease won\u2019t progress. This technology has the potential to change a lot of lives. There are no drugs that currently reverse the course of a disease, but we\u2019re hopeful this could do that.\u201d<\/p>\n

\nDr. Guilak is also the Mildred B. Simon Professor of Orthopedic Surgery<\/a> and Biomedical Engineering<\/a> at Washington University in St. Louis and co-Director of the Washington University Center of Regenerative Medicine<\/a>. His team is working with the Food and Drug Administration (FDA) to begin clinical trials in the next 3-5 years. This research was supported by Shriners Children\u2019s and the National Institutes of Health.<\/p>\n

\nAbout Shriners Children\u2019s<\/p>\n

\nShriners Children\u2019s improves the lives of children by providing pediatric specialty care, conducting innovative research, and offering outstanding education programs for medical professionals. Children with orthopedic conditions, burns, spinal cord injuries, and cleft lip and palate are eligible for care, regardless of the families\u2019 ability to pay or insurance status, and receive all care and services in a compassionate, family-centered environment. For more information, please visit shrinerschildrens.org<\/a>.<\/p>\n

Contacts<\/b> <\/p>\n

\nJessica Williams
\n
618-772-2349
\n
PR@bammarketingagency.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Research Could Eventually Lead to New Treatment Methods for Cancer or Diabetes ST. LOUIS–(BUSINESS WIRE)–Shriners Children\u2019s researchers have developed a new way to use the body\u2019s natural internal clock to optimize the delivery of medications and increase their effectiveness. Shriners Children\u2019s St. Louis Director of Research Dr. Farshid Guilak recently published findings on a revolutionary … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-61812","6":"format-standard","7":"category-industry"},"yoast_head":"\nShriners Children\u2019s Researcher Pioneers New Method for Treating Rheumatoid and Juvenile Arthritis - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/shriners-childrens-researcher-pioneers-new-method-for-treating-rheumatoid-and-juvenile-arthritis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Shriners Children\u2019s Researcher Pioneers New Method for Treating Rheumatoid and Juvenile Arthritis - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Research Could Eventually Lead to New Treatment Methods for Cancer or Diabetes ST. LOUIS–(BUSINESS WIRE)–Shriners Children\u2019s researchers have developed a new way to use the body\u2019s natural internal clock to optimize the delivery of medications and increase their effectiveness. Shriners Children\u2019s St. Louis Director of Research Dr. Farshid Guilak recently published findings on a revolutionary ... 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