{"id":62038,"date":"2025-10-17T16:04:21","date_gmt":"2025-10-17T14:04:21","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/parabilis-medicines-presents-clinical-data-demonstrating-first-ever-drugging-of-key-cancer-driver-with-fog-001\/"},"modified":"2025-10-17T16:04:21","modified_gmt":"2025-10-17T14:04:21","slug":"parabilis-medicines-presents-clinical-data-demonstrating-first-ever-drugging-of-key-cancer-driver-with-fog-001","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/parabilis-medicines-presents-clinical-data-demonstrating-first-ever-drugging-of-key-cancer-driver-with-fog-001\/","title":{"rendered":"Parabilis Medicines Presents Clinical Data Demonstrating First-Ever Drugging of Key Cancer Driver with FOG-001"},"content":{"rendered":"
\n

\nWnt\/\u03b2-catenin pathway, first identified as a key cancer driver over 30 years ago and implicated in millions of cancer cases annually, is not addressed by any currently approved therapies<\/i><\/p>\n

\nOral presentation at ESMO 2025 shows FOG-001 \u2013 Parabilis\u2019s lead investigational Helicon\u2122 peptide, targeting the \u03b2-catenin:TCF interaction \u2013 demonstrated tumor reductions in 100% of desmoid patients with an 80% objective response rate in patients with more than one post-baseline scan<\/i><\/p>\n

\nAdditional presentations at AACR-NCI-EORTC, PCF, CTOS, and SNO will expand on FOG-001\u2019s potential across a range of rare and common Wnt\/\u03b2-catenin-driven solid tumors<\/i><\/p>\n

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Parabilis Medicines<\/a>, a clinical-stage biopharmaceutical company committed to creating extraordinary medicines for people living with cancer, today announced at the ESMO Congress 2025 the first-ever clinical data showing that its investigational FOG-001 therapy has successfully drugged \u03b2-catenin:TCF \u2013 a key cancer-driving node in the Wnt\/\u03b2-catenin pathway, until now considered \u201cundruggable.\u201d<\/p>\n

<\/a>
<\/a><\/p>\n

\nIn the ongoing Phase 1\/2 trial of FOG-001 in patients with a range of Wnt\/\u03b2-catenin-driven tumors, as of mid-August 2025, 12 patients with desmoid tumors had been dosed across three dose levels. Of the 10 patients who had at least one post-baseline scan, tumor reductions were observed at all dose levels with a 100% disease-control rate (DCR). Of the five patients with more than one post-baseline scan, an objective response rate (ORR) of 80% (4\/5) was observed, per RECIST 1.1. Responses were seen in both gamma secretase-naive and \u2013treated patients, and FOG-001 demonstrated clinically meaningful anti-tumor activity alongside acceptable safety and tolerability profiles.<\/p>\n

\nFOG-001 achieves its effect by blocking the interaction between \u03b2-catenin and the T-cell factor (TCF) family of transcription factors, the key driver of tumorigenesis in Wnt pathway-activated cancer cells. The data support further development of FOG-001 in patients with desmoid tumors, and suggest that FOG-001, unlike other available therapies for this disease, directly addresses the underlying mechanism of disease through inhibition of \u03b2-catenin.<\/p>\n

\n\u201cFor decades, scientists had said that the Wnt\/\u03b2-catenin:TCF interaction couldn\u2019t be drugged, but our data prove otherwise,\u201d said Mathai Mammen, M.D., Ph.D., Chairman, CEO and President of Parabilis Medicines. \u201cFOG-001 shows what bold science can achieve \u2014 taking on one of cancer\u2019s most important drivers and opening the door to an entirely new class of therapies. This milestone validates the power of Parabilis\u2019s distinctive Helicon peptides and marks an important step forward in our mission to create extraordinary medicines for patients.\u201d<\/p>\n

\nThe Wnt\/\u03b2-catenin pathway was first identified over 30 years ago as a fundamental driver of cancer and is implicated in millions of cases each year, across both common cancers \u2014 including gastrointestinal cancers like colorectal, hepatocellular, and gastric cancers \u2014 as well as many rare cancers such as desmoid tumors and adamantinomatous craniopharyngioma (ACP). Attempts to target the \u03b2-catenin:TCF interaction, the key downstream node within the Wnt pathway, have repeatedly failed until now with FOG-001.<\/p>\n

\nParabilis\u2019s Helicon\u2122 platform has overcome limitations of traditional small molecule therapeutics by designing stabilized \u03b1-helical peptides that gently penetrate cells and bind tightly to proteins with relatively flat binding surfaces. With FOG-001, Parabilis has achieved what decades of cancer research could not: directly drugging the \u201cundruggable\u201d \u03b2-catenin:TCF interaction.<\/p>\n

\nBeyond ESMO, additional clinical data on FOG-001 across a range of Wnt\/\u03b2-catenin-driven tumors will be presented at several additional upcoming scientific meetings, including the AACR-NCI-EORTC International Conference on Molecular Targets (October 22-26, Boston, MA), the Connective Tissue Oncology Society (CTOS) 2025 Annual Meeting (November 12-15, Boca Raton, FL), and the Society for Neuro-Oncology (SNO) 2025 Annual Meeting (November 19-23, Honolulu, HI). The company will also share new preclinical data on its allosteric active androgen receptor (ARON<\/sup>) and ERG degrader discovery programs for the treatment of prostate cancer at AACR-NCI-EORTC and the Prostate Cancer Foundation (PCF) Scientific Retreat (October 23-25, Carlsbad, CA).<\/p>\n

\nDetails of the presentations are as follows:<\/p>\n

\nESMO mini oral information:<\/b><\/p>\n

\nPresentation Title<\/b>: \u201cA Phase 1\/2 trial of FOG-001, a first-in-class direct \u03b2-catenin:TCF4 inhibitor: Safety and preliminary antitumor activity in patients with desmoid tumors\u201d
\n
Date and Time: Friday, October 17, 2025, 4:00 \u2013 5:30 p.m. CEST
\n
Session: Mini oral session: Sarcoma
\n
Location: Essen Auditorium, Hall 7.2A<\/p>\n

\nAACR-NCI-EORTC oral and poster information:<\/b><\/p>\n

\nTitle<\/b>: \u201cA Phase 1\/2 trial of FOG-001, a first-in-class direct \u03b2-catenin inhibitor, preliminary safety and efficacy in patients with solid tumors bearing Wnt pathway-activating mutations (WPAM+)\u201d
\n
Oral Presentation<\/i><\/b>
Date and Time: Friday, October 24, 2025, 10:00 \u2013 11:40 a.m. EDT
\n
Session: Plenary Session 4: Clinical Trials Plenary Session
\n
Location: Level 3, Ballroom AB
\n
Poster Presentation<\/i><\/b>
Date and Time: Friday, October 24, 2025, 12:30 \u2013 4:00 p.m. EDT
\n
Session: Poster Session B
\n
Location: Level 2, Exhibit Hall D<\/p>\n

\nPoster Title<\/b>: \u201cDistinct aspects of \u03b2-catenin biology drive multiple biologically rational FOG-001 combinations for MSS colorectal cancer\u201d
\n
Date and Time: Saturday, October 25, 2025, 12:30 \u2013 4:00 p.m. EDT
\n
Session: Poster Session C
\n
Location: Level 2, Exhibit Hall D<\/p>\n

\nPoster Title<\/b>: \u201cDegradation of the ETS transcription factor ERG by stabilized helical peptide (Helicon\u2122) degraders enable pharmacological validation in ERG-fusion prostate cancer models\u201d
\n
Date and Time: Friday, October 24, 2025, 12:30 \u2013 4:00 p.m. EDT
\n
Session: Poster Session B
\n
Location: Level 2, Exhibit Hall D<\/p>\n

\nPoster Title<\/b>: \u201cDiscovery of Helicon peptides for the selective degradation of the agonist-bound conformation of androgen receptor (ARON<\/sup>) in prostate cancer\u201d
\n
Date and Time: Friday, October 24, 2025, 12:30 \u2013 4:00 p.m. EDT
\n
Session: Poster Session B
\n
Location: Level 2, Exhibit Hall D<\/p>\n

\nPCF presentation and poster information:<\/b><\/p>\n

\nPoster Title<\/b>: \u201cDiscovery of Helicon peptides for the selective degradation of the agonist-bound conformation of androgen receptor (ARON<\/sup>) in prostate cancer\u201d
\n
Date and Time: Thursday, October 23, 2025, 7:30 \u2013 10:30 PM PDT
\n
Location: Costa De La Luna Ballroom<\/p>\n

\nPresentation Title<\/b>: \u201cDiscovery and Optimization of ERG Bifunctional, Stapled Peptide Degraders using Generative AI\u2013Driven Multi-Property Modeling\u201d
\n
Date and Time: Saturday, October 25, 2025, 12:45 \u2013 1:00 PM PDT
\n
Location: Costa Del Sol Ballroom<\/p>\n

\nCTOS poster information:<\/b><\/p>\n

\nPoster Title<\/b>: \u201cA Phase 1\/2 trial of FOG-001, a first-in-class direct \u03b2-catenin inhibitor: Safety and preliminary antitumor activity in patients with desmoid tumors (DT)\u201d
\n
Date and Time: Thursday, November 13, 2025, 5:30 \u2013 6:30 p.m. EST
\n
Session: Poster Reception: Soft Tissue Tumors<\/p>\n

\nSNO mini oral information:<\/b><\/p>\n

\nPresentation Title<\/b>: \u201cA Phase 1\/2 trial of FOG-001, a first-in-class direct \u03b2-catenin:TCF4 inhibitor: Safety and preliminary antitumor activity in adamantinomatous craniopharyngioma (ACP) patients\u201d
\n
Abstract Number: CTNI-10
\n
Date and Time: Friday, November 21, 2025, 11:30 \u2013 12:30 p.m. HST
\n
Session: Rapid Orals
\n
Location: Hawaii Convention Center, Kamehameha Exhibit Hall II & III<\/p>\n

\nAbout the Phase 1\/2 trial of FOG-001
\n
<\/b>FOG-001 is being evaluated in a first-in-human Phase 1\/2 multicenter, open-label study (NCT05919264) assessing its safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity. The trial includes dose-escalation and dose-expansion phases and is testing FOG-001 both as a monotherapy and in combination with other anticancer agents in patients with advanced or metastatic solid tumors likely or known to harbor a Wnt pathway\u2013activating mutation (WPAM).<\/p>\n

\nAbout FOG-001
\n
<\/b>FOG-001 is an investigational first-in-class competitive inhibitor of \u03b2-catenin interactions with the T-cell factor (TCF) family of transcription factors and is currently in clinical development. By directly targeting the \u03b2-catenin:TCF <\/sub>protein-protein interaction, FOG-001 is intended to block the Wnt signaling pathway irrespective of the various APC and \u03b2-catenin mutations that typically drive disease.<\/p>\n

\nFOG-001 combines key features that distinguish it from previously reported Wnt\/\u03b2-catenin pathway modulators: FOG-001 acts inside the cell where it binds directly to the key oncogenic driver \u03b2-catenin; and FOG-001 blocks the Wnt pathway at the key downstream node, disrupting the interaction between \u03b2-catenin and the TCF transcription factors, thereby abrogating the signal transmission by which Wnt pathway mutations are believed to drive oncogenesis.<\/p>\n

\nFOG-001 is currently being evaluated in a first-in-human Phase 1\/2 clinical trial in patients with locally advanced or metastatic solid tumors.<\/p>\n

\nAbout Parabilis Medicines
\n
<\/b>Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines that unlock high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides \u2013 Helicons\u2122 \u2013 capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.<\/p>\n

\nHeadquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead candidate, FOG-001, is the first direct inhibitor of the interaction between \u03b2-catenin and the T-cell factor (TCF) family of transcription factors, implicated in colorectal cancer, desmoid tumors, and a range of other Wnt\/\u03b2-catenin-driven tumors. Parabilis is also advancing investigational degraders of ERG and ARON<\/sup> for the treatment of prostate cancer, as well as other preclinical programs.<\/p>\n

\nLearn more about how the company is advancing a new generation of precision cancer medicines with the potential to meaningfully alter the trajectory of disease for patients in need: www.parabilismed.com<\/a>.<\/p>\n

Contacts<\/b> <\/p>\n

\nMedia Contact<\/b>
Ten Bridge Communications
\n
Nichole Bobbyn
\n
nichole@tenbridgecommunications.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Wnt\/\u03b2-catenin pathway, first identified as a key cancer driver over 30 years ago and implicated in millions of cancer cases annually, is not addressed by any currently approved therapies Oral presentation at ESMO 2025 shows FOG-001 \u2013 Parabilis\u2019s lead investigational Helicon\u2122 peptide, targeting the \u03b2-catenin:TCF interaction \u2013 demonstrated tumor reductions in 100% of desmoid patients … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-62038","6":"format-standard","7":"category-industry"},"yoast_head":"\nParabilis Medicines Presents Clinical Data Demonstrating First-Ever Drugging of Key Cancer Driver with FOG-001 - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/parabilis-medicines-presents-clinical-data-demonstrating-first-ever-drugging-of-key-cancer-driver-with-fog-001\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Parabilis Medicines Presents Clinical Data Demonstrating First-Ever Drugging of Key Cancer Driver with FOG-001 - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Wnt\/\u03b2-catenin pathway, first identified as a key cancer driver over 30 years ago and implicated in millions of cancer cases annually, is not addressed by any currently approved therapies Oral presentation at ESMO 2025 shows FOG-001 \u2013 Parabilis\u2019s lead investigational Helicon\u2122 peptide, targeting the \u03b2-catenin:TCF interaction \u2013 demonstrated tumor reductions in 100% of desmoid patients ... 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