{"id":62444,"date":"2026-01-06T04:05:52","date_gmt":"2026-01-06T03:05:52","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/natera-presents-updated-analyses-from-altair-clinical-trial-at-asco-gi\/"},"modified":"2026-01-06T04:05:52","modified_gmt":"2026-01-06T03:05:52","slug":"natera-presents-updated-analyses-from-altair-clinical-trial-at-asco-gi","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/natera-presents-updated-analyses-from-altair-clinical-trial-at-asco-gi\/","title":{"rendered":"Natera Presents Updated Analyses From ALTAIR Clinical Trial at ASCO GI"},"content":{"rendered":"
\n

\nStudy showed a statistically significant disease-free survival (DFS) benefit in all SignateraTM<\/sup>-positive patients following blinded central review<\/i><\/p>\n

AUSTIN, Texas–(BUSINESS WIRE)–Natera, Inc.<\/a> (NASDAQ: NTRA), a global leader in cell-free DNA and precision medicine, today announced that new data from the ALTAIR trial will be presented at the 2026 American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI), taking place January 8-10, 2026.<\/p>\n

<\/a>
<\/a><\/p>\n

\nA new analysis will be presented from the randomized, double-blind, phase III ALTAIR clinical trial (NCT04457297). ALTAIR examined treatment on molecular recurrence (TOMR) with Trifluridine\/Tipiracil (FTD\/TPI) in Signatera-positive patients with stage I-IV colorectal cancer (CRC). This investigator-initiated analysis, based on a post-hoc blinded central radiographic review that resulted in the reclassification of a subset of cases, showed a statistically significant DFS benefit of FTD\/TPI vs. placebo in all patients (median DFS 9.23 vs 5.55 months; HR: 0.75, 95% CI: 0.55-0.98; P=0.0406). Importantly, these findings represent a substantial update from the previously reported overall ALTAIR analysis, which showed a numerical DFS improvement that did not reach statistical significance in the full study population.<\/p>\n

\nIn addition to ALTAIR, Natera\u2019s ASCO GI presentations include a large-scale study on Signatera velocity as a prognostic marker for relapse risk stratification. In the study, CRC patients whose Signatera levels doubled in one month or less experienced ~40% shorter recurrence free survival (RFS) vs patients with slower doubling time. The prognostic association between the rate of circulating tumor DNA (ctDNA) increase and recurrence risk remained significant for patients who received adjuvant chemotherapy, as well as those who did not. This data is specific to Natera\u2019s quantification method, which uses mean tumor molecules (MTM) per mL of plasma.<\/p>\n

\n\u201cNatera\u2019s unmatched scale of evidence across tumor types uniquely positions the company to define ctDNA dynamics and translate them into meaningful biological insight and clinical action,\u201d said Adham Jurdi, M.D., senior medical director of GI oncology at Natera. \u201cWe believe these capabilities, including TOMR approaches, can ultimately support more precise risk stratification and cancer management.\u201d<\/p>\n

\nThe full list of 14 presentations at ASCO GI includes:<\/b><\/p>\n

\nJanuary 8, 11:30 AM PT | Abstract # 440
\n
<\/b>Presenter: Sahar Forootan Sedigh
\n
Tumor-informed ctDNA monitoring during surveillance for early detection of recurrence in patients with stage II\/III esophageal cancer treated with chemoradiation<\/i><\/p>\n

\nJanuary 8, 11:30 AM PT | Abstract # 843
\n
<\/b>Presenter: Axel Grothey, M.D.
\n
AI-assisted automated abstraction for enhanced patient insights in gastrointestinal cancers<\/i><\/p>\n

\nJanuary 8, 11:30 AM PT | Abstract # 814
\n
<\/b>Presenter: Gladys Magaly Rodriguez, M.D., MS
\n
Characterization of DPYD variants across ancestries in a large real-world cohort of cancer patients<\/i><\/p>\n

\nJanuary 9, 11:30 AM PT | Abstract # 778
\n
<\/b>Presenter: Elishama Kanu, M.D., MA
\n
Prognostic value of ctDNA monitoring in patients with resectable pancreatic ductal adenocarcinoma during surveillance<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # 163
\n
<\/b>Presenter: George Q. Zhang, M.D., MPH
\n
Physical activity and molecular residual disease (MRD) in stage III colon cancer: Findings from CALGB (Alliance)\/SWOG 80702<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # 216
\n
<\/b>Presenter: Saori Mishima, M.D., Ph.D.
\n
Assessing adjuvant chemotherapy benefit in younger and older molecular residual disease-positive patients with stage II\/III colorectal cancer<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # 221
\n
<\/b>Presenter: Naoya Akazawa, M.D.
\n
Prognostic value of presurgical circulating tumor DNA (ctDNA) levels and other clinical factors in colon cancer<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # 220
\n
<\/b>Presenter: Koji Ando
\n
Correlation between the timing of recurrence and circulating tumor DNA (ctDNA) doubling time in patients (pts) with resected colon cancer<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # 153
\n
<\/b>Presenter: Kozo Kataoka, M.D., Ph.D.
\n
Adjuvant mFOLFOXFIRI after curative-intent resection of oligometastatic colorectal cancer: Phase II FANTASTIC trial<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # TPS268
\n
<\/b>Presenter: Anwaar Saeed, M.D.
\n
NSABP FC-13 (EMPIRE): A phase II platform study of cemiplimab monotherapy or cemiplimab-based combinations in patients with colorectal cancer and minimal residual disease (MRD) after definitive therapy<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # 138
\n
<\/b>Presenter: Jun Watanabe, M.D., Ph.D.
\n
Post-hoc central radiological review of the ALTAIR study in patients with molecular residual disease (MRD) following curative resection of colorectal cancer (CRC)<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # TPS245
\n
<\/b>Presenter: Sarah Sawyer, Ph.D.
\n
Design of a hybrid site and decentralized clinical research study of an early detection blood test for colorectal cancer<\/i><\/p>\n

\nJanuary 10, 7:00 AM PT | Abstract # 217
\n
<\/b>Presenter: Yoshiaki Nakamura, M.D., Ph.D.
\n
Quantification of circulating tumor DNA (ctDNA) using a methylation-based, tissue-free colorectal cancer (CRC) test for the detection of molecular residual disease (MRD)<\/i><\/p>\n

\nJanuary 10, 11:30 AM PT | Abstract # 12 (Oral Presentation)
\n
<\/b>Presenter: Hideaki Bando, M.D., Ph.D.
\n
Impact of postoperative ctDNA dynamics on eligibility for the ALTAIR randomized trial in patients with colorectal cancer: Implications for clinical trial enrollment<\/i><\/p>\n

\nAbout Natera<\/b><\/p>\n

\nNatera\u2122 is a global leader in cell-free DNA and precision medicine, dedicated to oncology, women\u2019s health, and organ health. We aim to make personalized genetic testing and diagnostics part of the standard-of-care to protect health and inform earlier, more targeted interventions that help lead to longer, healthier lives. Natera\u2019s tests are supported by more than 325 peer-reviewed publications that demonstrate excellent performance. Natera operates ISO 13485-certified and CAP-accredited laboratories certified under the Clinical Laboratory Improvement Amendments (CLIA) in Austin, Texas, and San Carlos, California, and through Foresight Diagnostics, its subsidiary, operates an ISO 27001-certified and CAP-accredited laboratory certified under CLIA in Boulder, Colorado. For more information, visit www.natera.com<\/a>.<\/p>\n

\nForward-Looking Statements<\/b><\/p>\n

\nAll statements other than statements of historical facts contained in this press release are forward-looking statements and are not a representation that Natera\u2019s plans, estimates, or expectations will be achieved. These forward-looking statements represent Natera\u2019s expectations as of the date of this press release, and Natera disclaims any obligation to update the forward-looking statements. These forward-looking statements are subject to known and unknown risks and uncertainties that may cause actual results to differ materially, including with respect to whether the results of clinical or other studies will support the use of our product offerings, the impact of results of such studies, our expectations of the reliability, accuracy and performance of our tests, or of the benefits of our tests and product offerings to patients, providers and payers. Additional risks and uncertainties are discussed in greater detail in \u201cRisk Factors\u201d in Natera\u2019s recent filings on Forms 10-K and 10-Q and in other filings Natera makes with the SEC from time to time. These documents are available at www.natera.com\/investors<\/a> and www.sec.gov<\/a>.<\/p>\n

Contacts<\/b> <\/p>\n

\nInvestor Relations: Mike Brophy, CFO, Natera, Inc., investor@natera.com<\/a>
Media: Lesley Bogdanow, VP of Corporate Communications, Natera, Inc., pr@natera.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Study showed a statistically significant disease-free survival (DFS) benefit in all SignateraTM-positive patients following blinded central review AUSTIN, Texas–(BUSINESS WIRE)–Natera, Inc. (NASDAQ: NTRA), a global leader in cell-free DNA and precision medicine, today announced that new data from the ALTAIR trial will be presented at the 2026 American Society of Clinical Oncology Gastrointestinal Cancers Symposium … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-62444","6":"format-standard","7":"category-industry"},"yoast_head":"\nNatera Presents Updated Analyses From ALTAIR Clinical Trial at ASCO GI - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/natera-presents-updated-analyses-from-altair-clinical-trial-at-asco-gi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Natera Presents Updated Analyses From ALTAIR Clinical Trial at ASCO GI - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Study showed a statistically significant disease-free survival (DFS) benefit in all SignateraTM-positive patients following blinded central review AUSTIN, Texas–(BUSINESS WIRE)–Natera, Inc. 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