{"id":62619,"date":"2026-02-09T19:06:01","date_gmt":"2026-02-09T18:06:01","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/agenus-to-present-new-data-at-aacr-io-exploring-systemic-and-tumor-inflammation-biomarkers-with-bot-bal-in-immunologically-cold-tumors\/"},"modified":"2026-02-09T19:06:01","modified_gmt":"2026-02-09T18:06:01","slug":"agenus-to-present-new-data-at-aacr-io-exploring-systemic-and-tumor-inflammation-biomarkers-with-bot-bal-in-immunologically-cold-tumors","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/agenus-to-present-new-data-at-aacr-io-exploring-systemic-and-tumor-inflammation-biomarkers-with-bot-bal-in-immunologically-cold-tumors\/","title":{"rendered":"Agenus to Present New Data at AACR-IO Exploring Systemic and Tumor Inflammation Biomarkers with BOT\/BAL in Immunologically Cold Tumors"},"content":{"rendered":"
\n

LEXINGTON, Mass.–(BUSINESS WIRE)–$AGEN<\/a> #AACRIO<\/a>—Agenus Inc<\/a>. (Nasdaq: AGEN<\/b>), a leader in immuno-oncology, today announced that new translational and clinical biomarker analyses from its botensilimab (BOT) immunotherapy program have been accepted for poster presentation at the American Association for Cancer Research- Immuno-Oncology (AACR-IO) Conference, taking place in Los Angeles, CA on February 18\u201321, 2026.<\/p>\n

<\/a>
<\/a><\/p>\n

\nThe abstract, titled \u201cSystemic and tumor-microenvironment inflammation shape outcomes in patients with immunologically cold, treatment-refractory tumors treated with Fc-enhanced anti\u2013CTLA-4 botensilimab,\u201d evaluates how systemic inflammatory markers, tumor microenvironment (TME) immune activity, and peripheral immune cell states are associated with clinical outcomes in patients treated with BOT alone or in combination with balstilimab (BAL).<\/p>\n

\nBotensilimab is an Fc-enhanced multifunctional anti-CTLA-4 antibody designed to help prime and activate the immune system, while BAL is an anti-PD-1 antibody designed to help sustain immune activity against cancer. Together, BOT+BAL targets complementary immune pathways and is being evaluated across multiple solid tumors, including immunologically \u201ccold\u201d or treatment-refractory cancers.<\/p>\n

\nPresentation Details:<\/span><\/b><\/p>\n

    \n
  1. \nPoster Presentation Title:<\/b> Systemic and tumor-microenvironment inflammation shape outcomes in patients with immunologically cold, treatment-refractory tumors treated with Fc-enhanced anti\u2013CTLA-4 botensilimab<\/li>\n<\/ol>\n\n\n\n\n\n\n
    \n

    \nPresenting Author:<\/b><\/p>\n<\/td>\n

    		<\/td>\n<\/td>\n<\/td>\n\n

    \nChloe Delepine PhD, Biomarker Operations, Agenus<\/p>\n<\/td>\n<\/tr>\n

    \n

    \nSession Date:<\/b><\/p>\n<\/td>\n

    		<\/td>\n<\/td>\n<\/td>\n\n

    \nThursday, February 19, 2026<\/p>\n<\/td>\n<\/tr>\n

    \n

    \nSession Time:<\/b><\/p>\n<\/td>\n

    		<\/td>\n<\/td>\n<\/td>\n\n

    \n12:15-3:15PM PT \/ 3:15-6:15 PM ET<\/p>\n<\/td>\n<\/tr>\n

    \n

    \nLocation:<\/b><\/p>\n<\/td>\n

    		<\/td>\n<\/td>\n<\/td>\n\n

    \nJW Marriott, <\/b>Platinum Ballroom<\/p>\n<\/td>\n<\/tr>\n

    \n

    \nPoster Session:<\/b><\/p>\n<\/td>\n

    		<\/td>\n<\/td>\n<\/td>\n\n

    \nPoster Session B<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

    \nAbout Agenus<\/b><\/p>\n

    \nAgenus is a leading immuno-oncology company targeting cancer with a comprehensive pipeline of immunological agents. The company was founded in 1994 with a mission to expand patient populations benefiting from cancer immunotherapy through combination approaches, using a broad repertoire of antibody therapeutics, adoptive cell therapies (through MiNK Therapeutics) and adjuvants. Agenus has robust end-to-end development capabilities, across commercial and clinical cGMP manufacturing facilities, research and discovery, and a global clinical operations footprint. Agenus is headquartered in Lexington, MA. For more information, visit www.agenusbio.com<\/a> or @agenus_bio. Information that may be important to investors will be routinely posted on our website and social media channels.<\/p>\n

    \nAbout Botensilimab (BOT)<\/b><\/p>\n

    \nBotensilimab (BOT) is a human Fc enhanced multifunctional anti-CTLA-4 antibody designed to boost both innate and adaptive anti-tumor immune responses. Its novel design leverages mechanisms of action to extend immunotherapy benefits to \u201ccold\u201d tumors which generally respond poorly to standard of care or are refractory to conventional PD-1\/CTLA-4 therapies and investigational therapies. Botensilimab augments immune responses across a wide range of tumor types by priming and activating T cells, downregulating intratumoral regulatory T cells, activating myeloid cells and inducing long-term memory responses.<\/p>\n

    \nApproximately 1,200 patients have been treated with botensilimab and\/or balstilimab in phase 1 and phase 2 clinical trials. Botensilimab alone, or in combination with Agenus\u2019 investigational PD-1 antibody, balstilimab, has shown clinical responses across nine metastatic, late-line cancers. For more information about botensilimab trials, visit www.clinicaltrials.gov<\/a>.<\/p>\n

    \nAbout Balstilimab (BAL)<\/b><\/p>\n

    \nBalstilimab is a novel, fully human monoclonal immunoglobulin G4 (IgG4) designed to block PD-1 (programmed cell death protein 1) from interacting with its ligands PD-L1 and PD-L2. It has been evaluated in more than 900 patients to date and has demonstrated clinical activity and a favorable tolerability profile in several tumor types.<\/p>\n

    \nForward-Looking Statements<\/b><\/p>\n

    \nThis press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding its botensilimab and balstilimab programs, expected regulatory timelines and filings, and any other statements containing the words “may,” “believes,” “expects,” “anticipates,” “hopes,” “intends,” “plans,” “forecasts,” “estimates,” “will,” \u201cestablish,\u201d \u201cpotential,\u201d \u201csuperiority,\u201d \u201cbest in class,\u201d and similar expressions are intended to identify forward-looking statements. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Annual Report on Form 10-K for 2024, and subsequent Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.<\/p>\n

    \nSource<\/b>: Agenus Bio<\/p>\n

    Contacts<\/b> <\/p>\n

    \nInvestors : <\/b>917-362-1370 | investor@agenusbio.com<\/a>
    Media: <\/b>781-674-4422 |     communications@agenusbio.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    LEXINGTON, Mass.–(BUSINESS WIRE)–$AGEN #AACRIO—Agenus Inc. (Nasdaq: AGEN), a leader in immuno-oncology, today announced that new translational and clinical biomarker analyses from its botensilimab (BOT) immunotherapy program have been accepted for poster presentation at the American Association for Cancer Research- Immuno-Oncology (AACR-IO) Conference, taking place in Los Angeles, CA on February 18\u201321, 2026. The abstract, titled … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-62619","6":"format-standard","7":"category-industry"},"yoast_head":"\nAgenus to Present New Data at AACR-IO Exploring Systemic and Tumor Inflammation Biomarkers with BOT\/BAL in Immunologically Cold Tumors - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/agenus-to-present-new-data-at-aacr-io-exploring-systemic-and-tumor-inflammation-biomarkers-with-bot-bal-in-immunologically-cold-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Agenus to Present New Data at AACR-IO Exploring Systemic and Tumor Inflammation Biomarkers with BOT\/BAL in Immunologically Cold Tumors - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"LEXINGTON, Mass.–(BUSINESS WIRE)–$AGEN #AACRIO—Agenus Inc. 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