{"id":62629,"date":"2026-02-11T07:06:02","date_gmt":"2026-02-11T06:06:02","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/galderma-expands-restylane-portfolio-in-japan-with-launch-of-obt-hyaluronic-acid-injectables-restylane-defyne-and-refyne\/"},"modified":"2026-02-11T07:06:02","modified_gmt":"2026-02-11T06:06:02","slug":"galderma-expands-restylane-portfolio-in-japan-with-launch-of-obt-hyaluronic-acid-injectables-restylane-defyne-and-refyne","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/galderma-expands-restylane-portfolio-in-japan-with-launch-of-obt-hyaluronic-acid-injectables-restylane-defyne-and-refyne\/","title":{"rendered":"Galderma Expands Restylane\u00ae Portfolio in Japan With Launch of OBT\u2122 Hyaluronic Acid Injectables Restylane Defyne\u2122 and Refyne\u2122"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\nRestylane<sup>\u00ae<\/sup> Refyne\u2122 and Restylane Defyne<sup>\u2122<\/sup> are the first Optimal Balance Technology (OBT\u2122) hyaluronic acid injectables ever approved and launched in Japan, bringing advanced flexibility and natural movement to the market<sup>1,2<\/sup><\/li>\n<li>\nThis expands Galderma\u2019s Restylane portfolio in Japan to four products, enabling treatment of a wider spectrum of patient and practitioner needs<sup>3,4<\/sup><\/li>\n<li>\nThese two new launches underscore Galderma\u2019s accelerating growth across the Japan &amp; Asia Pacific (JPAC) region<\/li>\n<\/ul>\n<p>ZUG, Switzerland&#8211;(BUSINESS WIRE)&#8211;Galderma (SIX: GALD), the pure-play dermatology category leader, has announced the launch of Restylane Defyne and Restylane Refyne: the first OBT\u2011based hyaluronic acid injectables ever authorized in Japan.<sup>1,2<\/sup> The products \u2013 designed for injection into the mid-to-deep dermis for the correction of moderate to severe facial wrinkles and folds \u2013 are now commercially available in the market.<sup>1,2<\/sup><\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20260210555523\/en\/2715801\/5\/GALDERMA_LOGO_BLACK_RGB.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20260210555523\/en\/2715801\/22\/GALDERMA_LOGO_BLACK_RGB.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20260210555523\/en\/2715801\/5\/GALDERMA_LOGO_BLACK_RGB.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20260210555523\/en\/2715801\/21\/GALDERMA_LOGO_BLACK_RGB.jpg\"><\/a><\/p>\n<p>\nRestylane Defyne and Refyne leverage the unique balance of softness, flexibility, and support delivered by Galderma\u2019s proprietary OBT \u2013 designed to move in harmony with facial expressions while maintaining shape and lift \u2013 and are the first and only hyaluronic acid injectables clinically proven to restore youthful facial expressions.<sup>1,2,5-11<\/sup> Restylane Refyne offers a smooth, flexible gel, ideal for delicate, highly expressive areas, while Restylane Defyne provides support for areas such as the jawline and deeper facial folds.<sup>1,2,5-11<\/sup> These launches mark a major milestone for Galderma and represent an important chapter in its JPAC growth strategy, supporting the company\u2019s continuing expansion in one of the region\u2019s most dynamic aesthetics markets.<\/p>\n<table cellspacing=\"0\" class=\"bwblockalignl bwtablemarginb bwwidth100\">\n<tr>\n<td class=\"bwvertalignt bwpadl0 bwwidth100 bwrowaltcolor0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwalignc bwcellpmargin\">\n\u201cThe introduction of OBT technology to Japan is a significant milestone not only for clinicians but for the region\u2019s aesthetic landscape as a whole. By combining the power of both NASHA<sup>\u00ae<\/sup> and OBT within the Restylane portfolio in Japan, physicians can tailor treatments more precisely than ever before. This broader set of tools supports natural\u2011looking, expressive outcomes and aligns Japan with international best practice.\u201d<\/p>\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwalignc bwcellpmargin\">\n<b>DR. STEPHANIE LAM<\/b><\/p>\n<p class=\"bwalignc bwcellpmargin\">\n<b>PLASTIC SURGEON, CENTRAL HEALTH MEDICAL PRACTICE<\/b><\/p>\n<p class=\"bwalignc bwcellpmargin\">\n<b>HONG KONG<\/b><\/p>\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\nThe Restylane portfolio in Japan now includes four products in total, with Refyne and Defyne joining NASHA-powered products, Restylane Classyc<sup>\u2122<\/sup> and Restylane Lyft<sup>\u2122<\/sup>.<sup>1-4<\/sup> This versatile range enables clinicians to meet diverse patient needs, from soft, flexible formulations that smooth fine lines, to firmer gels that deliver contouring and support.<sup>1-7,12,13<\/sup><\/p>\n<p>\nThe approvals of Restylane Refyne and Defyne in Japan were based on two pivotal, double-blinded, randomized, active-controlled phase III studies investigating the products in 171 and 162 subjects, respectively. Restylane Refyne and Defyne met the studies\u2019 endpoints, demonstrating a clinically meaningful improvement in wrinkle severity for up to 12 months, with most patients reporting at least a 1-grade improvement in self-assessment scores after six weeks.<sup>1,2<\/sup><\/p>\n<table cellspacing=\"0\" class=\"bwblockalignl bwtablemarginb bwwidth100\">\n<tr>\n<td class=\"bwpadl0 bwwidth100 bwrowaltcolor0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwalignc bwcellpmargin\">\n\u201cThe approval of Restylane Defyne and Refyne \u2013 the first OBT HA injectables ever authorized in Japan \u2013 is a landmark moment for Galderma in the region. A decade after NASHA\u2019s introduction to this market, we are proud to now offer a fully rounded Restylane portfolio that gives healthcare professionals even more precision and flexibility to meet the needs of their patients. Japan is an important growth engine for our business, and this milestone underscores our long-term commitment to bringing world-leading aesthetic technologies to the region.\u201d<\/p>\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0<\/p>\n<p class=\"bwalignc bwcellpmargin\">\n<b>HON KEONG CHOO<\/b><\/p>\n<p class=\"bwalignc bwcellpmargin\">\n<b>HEAD OF JPAC REGION<\/b><\/p>\n<p class=\"bwalignc bwcellpmargin\">\n<b>GALDERMA<\/b><\/p>\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\nWith over 30 years of innovation and more than 77 million treatments administered worldwide, Restylane is highly relevant in addressing some of today\u2019s most significant aesthetic trends and needs, from improving facial harmony following medication-driven weight loss to growing concerns around menopause-related skin health and aging.<sup>5,14-17<\/sup> The arrival of OBT technology in Japan now aligns the market more closely with global Restylane availability, reinforcing the brand\u2019s position as the world\u2019s most scientifically studied and diverse hyaluronic acid injectables range.<\/p>\n<p>\n<b>About the Restylane portfolio<br \/>\n<br \/><\/b>Restylane hyaluronic acid treatments are designed differently to go beyond volumizing for natural-looking results.<sup>4,5,18,19<\/sup> Our hyaluronic acid is minimally modified and our innovative manufacturing process preserves its biocompatibility while creating individual products designed for a specific purpose.<sup>20-22<\/sup> Powered by NASHA, NASHA HD\u2122, OBT and SB-NASHA\u2122 technologies, Restylane offers gels with the highest firmness to the highest flexibility, enabling personalized treatments that deliver structural support, natural-looking results, and a healthy glow.<sup>12,13,23,24<\/sup> Trusted for almost three decades, our hyaluronic acid gels work in sync with your skin for 100% natural-looking results.<sup>5-7<\/sup><\/p>\n<p>\n<b>About Galderma<br \/>\n<br \/><\/b>Galderma (SIX: GALD) is the pure-play dermatology category leader, present in approximately 90 countries. We deliver an innovative, science-based portfolio of premium flagship brands and services that span the full spectrum of the fast-growing dermatology market through Injectable Aesthetics, Dermatological Skincare and Therapeutic Dermatology. Since our foundation in 1981, we have dedicated our focus and passion to the human body\u2019s largest organ \u2013 the skin \u2013 meeting individual consumer and patient needs with superior outcomes in partnership with healthcare professionals. Because we understand that the skin we are in shapes our lives, we are advancing dermatology for every skin story. For more information: <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.galderma.com&amp;esheet=54421453&amp;newsitemid=20260210555523&amp;lan=en-US&amp;anchor=www.galderma.com&amp;index=1&amp;md5=834e3566767b0fdb72b1a2cf46093626\" rel=\"nofollow\" shape=\"rect\">www.galderma.com<\/a>.<\/p>\n<p>\n<b>References<\/b><\/p>\n<ol class=\"bwlistdecimal\">\n<li>\nRestylane<sup>\u00ae<\/sup> Defyne\u2122. IFU. Japan. Available <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.restylanejapan.jp%2Fsites%2Fdefault%2Ffiles%2F2025-11%2FIFU%2520Restylane%2520Defyne.pdf&amp;esheet=54421453&amp;newsitemid=20260210555523&amp;lan=en-US&amp;anchor=online&amp;index=2&amp;md5=d7a7db6ad59f73f6fec754ba43eeb629\" rel=\"nofollow\" shape=\"rect\">online<\/a>. Accessed February 2026<\/li>\n<li>\nRestylane<sup>\u00ae<\/sup> Refyne\u2122. IFU. Japan. Available <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.restylanejapan.jp%2Fsites%2Fdefault%2Ffiles%2F2025-11%2FIFU%2520Restylane%2520Refyne.pdf&amp;esheet=54421453&amp;newsitemid=20260210555523&amp;lan=en-US&amp;anchor=online&amp;index=3&amp;md5=08c7fa0fe548eff92ec2c8394c4d028a\" rel=\"nofollow\" shape=\"rect\">online<\/a>. Accessed February 2026<\/li>\n<li>\nRestylane<sup>\u00ae<\/sup> Lyft\u2122. IFU. Japan. Available <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.restylanejapan.jp%2Fsites%2Fdefault%2Ffiles%2F2025-11%2FIFU%2520Restylane%2520LYFT%2520Lido.pdf&amp;esheet=54421453&amp;newsitemid=20260210555523&amp;lan=en-US&amp;anchor=online&amp;index=4&amp;md5=b05c4abd89de7adcb1a26b696fcde857\" rel=\"nofollow\" shape=\"rect\">online<\/a>. Accessed February 2026<\/li>\n<li>\nRestylane<sup>\u00ae<\/sup> Classyc\u2122. IFU. Japan. Available <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.restylanejapan.jp%2Fsites%2Fdefault%2Ffiles%2F2025-11%2FIFU%2520Restylane%2520Lido_0.pdf&amp;esheet=54421453&amp;newsitemid=20260210555523&amp;lan=en-US&amp;anchor=online&amp;index=5&amp;md5=a0e9bf57908f3bddb461da10d1114928\" rel=\"nofollow\" shape=\"rect\">online<\/a>. Accessed February 2026<\/li>\n<li>\nDi Gregorio C, et al. 25+ years of experience with the Restylane portfolio of injectable HA fillers for facial aesthetic treatment. E-poster presented at AMWC; March 27-29, 2024; Monaco<\/li>\n<li>\nSolish N, et al. Dynamics of HA fillers formulated to maintain natural facial expression.<i> J Cosmet Dermatol.<\/i> 2019;18(3):738-746. doi: 10.1111\/jocd.12961<\/li>\n<li>\nPhilipp\u2010Dormston WG, et al. Perceived naturalness of facial expression after HA filler injection in nasolabial folds and lower face.<i> J Cosmet Dermatol.<\/i> 2020;19(7):1600-1606. doi: 10.1111\/jocd.13205<\/li>\n<li>\nPhilipp\u2010Dormston WG, et al. Evaluating perceived naturalness of facial expression after fillers to the nasolabial folds and lower face with standardized video and photography.<i> Dermatol Surg.<\/i> 2018;44(6):826-832. doi: 10.1097\/DSS.0000000000001419.<\/li>\n<li>\nGalderma. Data on file. MA-43049. xStrain and G\u2019 Global HA filler rheology data. 2023<\/li>\n<li>\nGalderma. Data on file. MA-42769. Restylane Defyne Clinical study report. 2020<\/li>\n<li>\n\u00d6hrlund \u00c5. Evaluation of rheometry amplitude sweep cross-over point as an index of flexibility for HA fillers.<b> <\/b><i>JCDSA<\/i><b>. <\/b>2018;8(2):47-54<\/li>\n<li>\nGalderma Data on file. MA-56724. X-strain and G\u2019 including Shaype<\/li>\n<li>\n\u00d6hrlund \u00c5. Differentiation of NASHA and OBT hyaluronic acid gels according to strength, flexibility, and associated clinical significance.<b> <\/b><i>J Drugs Dermatol<\/i><b>. <\/b>2014;23(1):1332-1336. doi: 10.36849\/JDD.7648<\/li>\n<li>\nGalderma. Data on file. MA-57232 [Updated]. 77 Million treated. 2025<\/li>\n<li>\nGalderma. Data on file. MA-55607. Restylane<sup>\u00ae<\/sup> 27 years data publications analysis. 2023<\/li>\n<li>\nFabi G, et al. The potential role of biostimulators\/dermal fillers to address menopause-related skin conditions. Poster presented at IMCAS; January 29-31, 2026; Paris, France<\/li>\n<li>\nLorenc ZP, et al. Synergistic efficacy and safety of poly-L-lactic acid biostimulator and hyaluronic acid filler for facial fullness post weight loss due to glucagon-like peptide-1 receptor agonist medication. Presented at the ASDS 2025 Annual Meeting; November 13-16; Chicago, United States<\/li>\n<li>\nNikolis A, et al. The role of clinical examination in midface volume correction using hyaluronic acid fillers: should patients be stratified by skin thickness?<i> Aesthet Surg J Open Forum<\/i>. 2020;2(1):1\u201312. doi: 10.1093\/asjof\/ojaa005<\/li>\n<li>\nTalarico S, et al. High patient satisfaction of a HA filler producing enduring full-facial volume restoration: an 18- month open multicenter study. <i>Dermatol Surg.<\/i> 2015;41:1361\u20131369. doi: 10.1097\/DSS.0000000000000549<\/li>\n<li>\nEdsman K, et al. Gel properties of hyaluronic acid dermal fillers. <i>Dermatol Surg<\/i>. 2012;38:1170\u20131179. doi: 10.1111\/j.1524-4725.2012.02472.x.<\/li>\n<li>\nGalderma. Data on file. MA-58650. Degree of modification of HA fillers.<\/li>\n<li>\nSeo K. Facial volumization with fillers. <i>Springer<\/i>. 2021;29\u201383. doi: 10.1007\/978-981-33-6212-3_2<\/li>\n<li>\nNikolis A, et al. Effectiveness and safety of a new hyaluronic acid injectable for augmentation and correction of chin retrusion. <i>J Drugs Dermatol.<\/i> 2024;23(4):255\u2013261. doi: 10.36849\/JDD.8145<\/li>\n<li>\nBelmontesi M et al. Injectable non-animal stabilized hyaluronic acid as a skin quality booster: an expert panel consensus. <i>J Drugs Dermatol.<\/i> 2018;17(1):83\u201388.<\/li>\n<\/ol>\n<p> <b>Contacts<\/b> <\/p>\n<p>\n<b>For further information:<\/b><\/p>\n<p>\nChristian Marcoux, M.Sc.<br \/>\n<br \/>Chief Communications Officer<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#97;&#x69;l&#116;&#x6f;&#x3a;c&#104;&#x72;&#x69;s&#116;&#x69;a&#110;&#x2e;&#x6d;a&#114;&#x63;&#x6f;u&#120;&#x40;g&#97;&#x6c;&#x64;e&#114;&#x6d;&#x61;&#46;&#99;&#x6f;&#x6d;\" rel=\"nofollow\" shape=\"rect\">&#x63;&#x68;&#x72;&#x69;&#115;&#116;ian&#x2e;&#x6d;&#x61;&#x72;&#99;&#111;ux&#64;&#x67;&#x61;&#x6c;&#x64;&#101;&#114;&#109;a&#46;&#x63;&#x6f;&#x6d;<\/a><br \/>+41 76 315 26 50<\/p>\n<p>\nRichard Harbinson<br \/>\n<br \/>Corporate Communications Director<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#97;&#x69;&#x6c;&#116;&#x6f;&#x3a;&#114;&#x69;&#x63;&#104;&#x61;&#x72;d&#x2e;&#x68;a&#x72;&#98;i&#x6e;&#115;o&#x6e;&#64;g&#x61;&#108;d&#x65;&#114;m&#x61;&#46;c&#x6f;&#109;\" rel=\"nofollow\" shape=\"rect\">&#114;&#x69;&#99;&#x68;&#97;&#x72;&#100;&#x2e;&#104;&#x61;&#114;&#x62;&#105;&#x6e;&#115;&#x6f;&#110;&#x40;&#103;&#x61;&#108;&#x64;&#101;&#x72;&#109;&#x61;&#46;&#x63;o&#x6d;<\/a><br \/>+41 76 210 60 62<\/p>\n<p>\nC\u00e9line Buguet<br \/>\n<br \/>Franchises and R&amp;D Communications Director<br \/>\n<br \/><a target=\"_blank\" href=\"&#109;&#97;&#x69;l&#116;&#x6f;&#x3a;c&#101;&#x6c;&#x69;n&#101;&#x2e;b&#117;&#x67;&#x75;e&#116;&#x40;&#x67;a&#108;&#x64;e&#114;&#x6d;&#x61;&#46;&#99;&#x6f;&#x6d;\" rel=\"nofollow\" shape=\"rect\">&#x63;&#101;&#x6c;&#105;n&#x65;&#46;b&#x75;&#103;&#x75;&#x65;t&#x40;&#103;a&#x6c;&#100;&#x65;&#x72;m&#x61;&#46;c&#x6f;&#109;<\/a><br \/>+41 76 249 90 87<\/p>\n<p>\nEmil Ivanov<br \/>\n<br \/>Head of Strategy, Investor Relations, and ESG<br \/>\n<br \/><a target=\"_blank\" href=\"&#x6d;&#x61;&#x69;&#x6c;&#x74;&#x6f;&#x3a;&#x65;&#x6d;&#x69;&#x6c;&#46;&#105;&#118;&#97;&#110;&#111;&#118;&#64;galde&#x72;&#x6d;&#x61;&#x2e;&#x63;&#x6f;&#x6d;\" rel=\"nofollow\" shape=\"rect\">&#101;&#x6d;i&#108;&#x2e;i&#118;&#x61;n&#x6f;&#x76;&#64;&#x67;a&#108;&#x64;e&#114;&#x6d;a&#x2e;&#x63;&#111;&#x6d;<\/a><br \/>+41 21 642 78 12<\/p>\n<p>\nJessica Cohen<br \/>\n<br \/>Investor Relations and Strategy Director<br \/>\n<br \/><a target=\"_blank\" href=\"m&#97;&#105;&#x6c;&#x74;o&#58;&#106;&#x65;&#x73;&#x73;i&#99;&#97;&#x2e;&#x63;oh&#101;&#x6e;&#x40;&#x67;a&#108;&#100;&#x65;&#x72;ma&#46;&#x63;&#x6f;&#x6d;\" rel=\"nofollow\" shape=\"rect\">j&#101;&#x73;&#x73;i&#99;&#97;&#x2e;&#x63;o&#104;&#101;&#x6e;&#x40;g&#97;&#x6c;&#x64;&#x65;r&#109;&#x61;&#x2e;c&#111;&#109;<\/a><br \/>+41 21 642 76 43<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Restylane\u00ae Refyne\u2122 and Restylane Defyne\u2122 are the first Optimal Balance Technology (OBT\u2122) hyaluronic acid injectables ever approved and launched in Japan, bringing advanced flexibility and natural movement to the market1,2 This expands Galderma\u2019s Restylane portfolio in Japan to four products, enabling treatment of a wider spectrum of patient and practitioner needs3,4 These two new launches &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/galderma-expands-restylane-portfolio-in-japan-with-launch-of-obt-hyaluronic-acid-injectables-restylane-defyne-and-refyne\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-62629","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Galderma Expands Restylane\u00ae Portfolio in Japan With Launch of OBT\u2122 Hyaluronic Acid Injectables Restylane Defyne\u2122 and Refyne\u2122 - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/galderma-expands-restylane-portfolio-in-japan-with-launch-of-obt-hyaluronic-acid-injectables-restylane-defyne-and-refyne\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Galderma Expands Restylane\u00ae Portfolio in Japan With Launch of OBT\u2122 Hyaluronic Acid Injectables Restylane Defyne\u2122 and Refyne\u2122 - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"Restylane\u00ae Refyne\u2122 and Restylane Defyne\u2122 are the first Optimal Balance Technology (OBT\u2122) hyaluronic acid injectables ever approved and launched in Japan, bringing advanced flexibility and natural movement to the market1,2 This expands Galderma\u2019s Restylane portfolio in Japan to four products, enabling treatment of a wider spectrum of patient and practitioner needs3,4 These two new launches ... 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