{"id":62756,"date":"2026-03-09T07:15:06","date_gmt":"2026-03-09T06:15:06","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/genentech-provides-update-on-phase-iii-persevera-study-in-er-positive-advanced-breast-cancer\/"},"modified":"2026-03-09T07:15:06","modified_gmt":"2026-03-09T06:15:06","slug":"genentech-provides-update-on-phase-iii-persevera-study-in-er-positive-advanced-breast-cancer","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/genentech-provides-update-on-phase-iii-persevera-study-in-er-positive-advanced-breast-cancer\/","title":{"rendered":"Genentech Provides Update on Phase III persevERA Study in ER-positive Advanced Breast Cancer"},"content":{"rendered":"<div>\n<ul class=\"bwlistdisc\">\n<li>\npersevERA Breast Cancer study did not meet the primary objective of a statistically significant improvement in progression-free survival, but a numerical improvement was observed<\/li>\n<\/ul>\n<ul class=\"bwlistdisc\">\n<li>\nGiredestrant plus palbociclib was well tolerated and adverse events were consistent with the known safety profiles of each individual treatment<\/li>\n<\/ul>\n<ul class=\"bwlistdisc\">\n<li>\nGenentech is committed to transforming ER-positive breast cancer care, anchored by the landmark success of lidERA in early-stage disease and evERA in the advanced setting<\/li>\n<\/ul>\n<ul class=\"bwlistdisc\">\n<li>\nThe FDA recently accepted the New Drug Application based on evERA data; Phase III lidERA data will be submitted to the FDA in the coming weeks<\/li>\n<\/ul>\n<ul class=\"bwlistdisc\">\n<li>\npersevERA is the first of two distinct Phase III studies in the first-line setting; pionERA study of giredestrant in combination with physician\u2019s choice of CDK4\/6 inhibitor in endocrine-resistant ER-positive breast cancer is expected to readout in 2027<\/li>\n<\/ul>\n<p>SOUTH SAN FRANCISCO, Calif.&#8211;(BUSINESS WIRE)&#8211;Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), announced today results from the Phase III persevERA Breast Cancer study evaluating investigational giredestrant in combination with palbociclib for people with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer. The study did not meet its primary objective of a statistically significant improvement in progression-free survival in the intent-to-treat population versus letrozole plus palbociclib, but a numerical improvement was observed. The adverse events for the giredestrant combination were manageable and consistent with the known safety profiles of each individual treatment.<\/p>\n<p><a href=\"https:\/\/mms.businesswire.com\/media\/20260308597396\/en\/2738585\/5\/GNE_Logo_Strapline_BLK_081525_%281%29.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20260308597396\/en\/2738585\/22\/GNE_Logo_Strapline_BLK_081525_%281%29.jpg\"><\/a><br \/><a href=\"https:\/\/mms.businesswire.com\/media\/20260308597396\/en\/2738585\/5\/GNE_Logo_Strapline_BLK_081525_%281%29.jpg\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20260308597396\/en\/2738585\/21\/GNE_Logo_Strapline_BLK_081525_%281%29.jpg\"><\/a><\/p>\n<p>\n\u201cWhile persevERA didn\u2019t meet its primary objective, we are confident in the potential of giredestrant to become a new standard-of-care endocrine therapy in early and advanced ER-positive breast cancer,&#8221; said Levi Garraway, M.D., Ph.D., chief medical officer and head of Global Product Development. \u201cWe believe there is a path forward for combining giredestrant with a CDK4\/6 inhibitor in the adjuvant setting and we are conducting further studies. The efficacy demonstrated in evERA and lidERA provides clear validation of the clinical activity of giredestrant and reinforces the strength of our expanding clinical development program.\u201d<\/p>\n<p>\nThe giredestrant clinical development program is made up of distinct studies designed to reflect the specific disease biology of each stage of breast cancer. Genentech will continue to advance the clinical development program to identify the people with ER-positive breast cancer who can derive the greatest benefit from giredestrant.<\/p>\n<p>\nGiredestrant Phase III clinical development program<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl\">\n<tr>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwleftsingle bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nTrial<\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nIndication<\/p>\n<\/td>\n<td class=\"bwvertalignt bwtopsingle bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nRegimen<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nlidERA<\/p>\n<p class=\"bwcellpmargin\">\nBreast Cancer<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nAdjuvant ER+\/HER2- breast cancer<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nGiredestrant vs. standard-of-care endocrine therapy (SoC ET)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\npersevERA Breast Cancer<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n1L ER+\/HER2- metastatic breast cancer<\/p>\n<p class=\"bwcellpmargin\">\n(endocrine-sensitive)<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nGiredestrant + palbociclib vs. letrozole plus palbociclib<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\npionERA Breast Cancer<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n1L ER+\/HER2- metastatic breast cancer<\/p>\n<p class=\"bwcellpmargin\">\n(endocrine-resistant)<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nGiredestrant + physician\u2019s choice of CDK4\/6 inhibitor vs. fulvestrant + physician\u2019s choice of CDK4\/6 inhibitor<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nevERA<\/p>\n<p class=\"bwcellpmargin\">\nBreast Cancer<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n2L+ ER+\/HER2- metastatic breast cancer<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nGiredestrant + everolimus vs. SoC ET + everolimus<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwvertalignt bwsinglebottom bwleftsingle bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nheredERA Breast Cancer<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\n1L maintenance ER+\/HER2+ metastatic breast cancer<\/p>\n<\/td>\n<td class=\"bwvertalignt bwsinglebottom bwrightsingle bwpadl1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"bwcellpmargin\">\nGiredestrant + dual HER2 blockade vs. HER2 blockade<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\nevERA was the first positive Phase III readout for giredestrant, followed by lidERA in the early-stage setting. The scientific rationale for lidERA was supported by prior results in the neoadjuvant setting, including the Phase II coopERA trial showing that giredestrant was superior to an aromatase inhibitor in reducing malignant cell division (Ki67 levels). This growing body of evidence underscores the potential of giredestrant to become a new standard-of-care endocrine therapy across ER-positive early-stage and advanced breast cancer.<\/p>\n<p>\npersevERA is the first of two distinct Phase III studies in the first-line setting; the pionERA study of giredestrant in combination with physician\u2019s choice of cyclin-dependent kinase (CDK)4\/6 inhibitor in endocrine-resistant ER-positive, HER2-negative breast cancer is expected to readout in 2027.<\/p>\n<p>\nThe United States Food and Drug Administration (FDA) recently accepted the New Drug Application based on the evERA data. In the coming weeks, Genentech will submit the giredestrant Phase III lidERA data in early-stage breast cancer to the FDA.<\/p>\n<p>\nThe full results from persevERA will be presented at an upcoming medical meeting.<\/p>\n<p>\n<b>About the persevERA Breast Cancer study<\/b><\/p>\n<p>\npersevERA Breast Cancer [<a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT04546009&amp;esheet=54441762&amp;newsitemid=20260308597396&amp;lan=en-US&amp;anchor=NCT04546009&amp;index=1&amp;md5=b47f34a9b1df06958cc1fda79cfa50db\" rel=\"nofollow\" shape=\"rect\">NCT04546009<\/a>] is a Phase III, randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of giredestrant plus palbociclib versus letrozole plus palbociclib as first-line treatment for people with estrogen receptor-positive, human epidermal growth factor receptor 2-negative, locally advanced or metastatic breast cancer. The study enrolled 992 patients globally.<\/p>\n<p>\nThe primary endpoint is investigator-assessed progression-free survival. Key secondary endpoints include overall survival, objective response rate, duration of response and safety.<\/p>\n<p>\n<b>About giredestrant<\/b><\/p>\n<p>\nGiredestrant is an investigational, oral, potent next-generation selective estrogen receptor degrader and full antagonist.<\/p>\n<p>\nGiredestrant is designed to block estrogen from binding to the estrogen receptor (ER), triggering its breakdown (known as degradation) and stopping or slowing down the growth of cancer cells.<\/p>\n<p>\nGiredestrant has an extensive clinical development program and is being investigated in five company-sponsored Phase III clinical trials that span multiple treatment settings and lines of therapy to benefit as many people as possible:<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nGiredestrant versus standard-of-care endocrine therapy (SoC ET) as adjuvant treatment in ER-positive, human epidermal growth factor receptor 2 (HER2)-negative early-stage breast cancer (lidERA Breast Cancer; <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT04961996%3Fcond%3DBreast%2520Cancer%26intr%3DGiredestrant%26term%3Dlidera%26rank%3D1&amp;esheet=54441762&amp;newsitemid=20260308597396&amp;lan=en-US&amp;anchor=NCT04961996&amp;index=2&amp;md5=a7c76c809bb6deba1e86c2b38c45fe7f\" rel=\"nofollow\" shape=\"rect\">NCT04961996<\/a>)<\/li>\n<li>\nGiredestrant plus everolimus versus SoC ET plus everolimus in ER-positive, HER2-negative, locally advanced or metastatic breast cancer (evERA Breast Cancer; <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT05306340&amp;esheet=54441762&amp;newsitemid=20260308597396&amp;lan=en-US&amp;anchor=NCT05306340&amp;index=3&amp;md5=206877c33bb15f21b42fc94aaa4c2d71\" rel=\"nofollow\" shape=\"rect\">NCT05306340<\/a>)<\/li>\n<li>\nGiredestrant plus palbociclib versus letrozole plus palbociclib in ER-positive, HER2-negative, endocrine-sensitive, recurrent locally advanced or metastatic breast cancer (persevERA Breast Cancer; <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT04546009%3Fcond%3DBreast%2520Cancer%26intr%3DGiredestrant%26term%3Dpersevera%26rank%3D1&amp;esheet=54441762&amp;newsitemid=20260308597396&amp;lan=en-US&amp;anchor=NCT04546009&amp;index=4&amp;md5=9bdec673e9c265d0c9f72f8f598b06c2\" rel=\"nofollow\" shape=\"rect\">NCT04546009<\/a>)<\/li>\n<li>\nGiredestrant plus investigator\u2019s choice of a cyclin-dependent kinase (CDK)4\/6 inhibitor versus fulvestrant plus a CDK4\/6 inhibitor in ER-positive, HER2-negative advanced breast cancer resistant to adjuvant endocrine therapy (pionERA Breast Cancer; <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT06065748%3Fcond%3DBreast%2520Cancer%26intr%3DGiredestrant%26term%3Dpionera%26rank%3D1&amp;esheet=54441762&amp;newsitemid=20260308597396&amp;lan=en-US&amp;anchor=NCT06065748&amp;index=5&amp;md5=96e3fe2a3be5b7835ccc8eda84694392\" rel=\"nofollow\" shape=\"rect\">NCT06065748<\/a>)<\/li>\n<li>\nGiredestrant plus dual HER2 blockade versus dual HER2 blockade in ER-positive, HER2-positive locally advanced or metastatic breast cancer (heredERA Breast Cancer; <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fstudy%2FNCT05296798%3Fcond%3DBreast%2520Cancer%26intr%3DGiredestrant%26term%3Dheredera%26rank%3D1&amp;esheet=54441762&amp;newsitemid=20260308597396&amp;lan=en-US&amp;anchor=NCT05296798&amp;index=6&amp;md5=29907f22477c5551a316363c668c74eb\" rel=\"nofollow\" shape=\"rect\">NCT05296798<\/a>)<\/li>\n<\/ul>\n<p>\n<b>About estrogen receptor (ER)-positive breast cancer<\/b><\/p>\n<p>\nGlobally, the burden of breast cancer continues to grow, with 2.3 million women diagnosed and 670,000 dying from the disease every year. Breast cancer remains the number one cause of cancer-related deaths amongst women, and the second most common cancer type.<\/p>\n<p>\nER-positive breast cancer accounts for approximately 70% of breast cancer cases. In the U.S. and EU5, an estimated 273,000 people are diagnosed in the early-stage setting, 88,000 people are diagnosed in first-line and 106,000 in the second and third-line setting combined.<\/p>\n<p>\nA defining feature of ER-positive breast cancer is that its tumor cells have receptors that attach to estrogen, which can contribute to tumor growth.<\/p>\n<p>\nDespite treatment advances, ER-positive breast cancer remains particularly challenging to treat due to its biological complexity. In the early-stage setting, up to a third of people eventually experience disease recurrence on or after adjuvant endocrine therapy treatment. Additionally, many have to interrupt or stop treatment early due to safety or tolerability issues, thereby increasing the risk of death. In advanced settings, resistance to endocrine therapy \u2013 particularly following treatment with cyclin-dependent kinase inhibitors \u2013 increases the risk of disease progression and is associated with poor outcomes.<\/p>\n<p>\nThere is an urgent need for more effective treatments that can delay clinical progression and reduce the burden of treatment on people\u2019s lives.<\/p>\n<p>\n<b>About Genentech in Breast Cancer<\/b><\/p>\n<p>\nGenentech has been advancing breast cancer research for more than 30 years with the goal of helping as many people with the disease as possible. Our medicines, along with companion diagnostic tests, have contributed to bringing breakthrough outcomes in multiple types of breast cancers. As our understanding of breast cancer biology rapidly improves, we are working to identify new biomarkers and approaches to treatment for other subtypes of the disease, including estrogen receptor-positive breast cancer, which is a form of hormone receptor-positive breast cancer, the most prevalent type of all breast cancers.<\/p>\n<p>\n<b>About Genentech<\/b><\/p>\n<p>\nFounded 50 years ago, Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious and life-threatening medical conditions. The company, a member of the Roche Group, has headquarters in South San Francisco, California. For additional information about the company, please visit <a target=\"_blank\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.gene.com%2F&amp;esheet=54441762&amp;newsitemid=20260308597396&amp;lan=en-US&amp;anchor=http%3A%2F%2Fwww.gene.com&amp;index=7&amp;md5=a58bc12b42eaac30b8076b8e35165a71\" rel=\"nofollow\" shape=\"rect\">http:\/\/www.gene.com<\/a>.<\/p>\n<p> <b>Contacts<\/b> <\/p>\n<p>\nMedia Contact: Jared Preston (650) 467-6800<br \/>\n<br \/>Advocacy Contact: Julie Burns (860) 881-6594<br \/>\n<br \/>Investor Contacts: Loren Kalm (650) 225-3217<br \/>\n<br \/>Bruno Eschli +41 61 68-75284<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>persevERA Breast Cancer study did not meet the primary objective of a statistically significant improvement in progression-free survival, but a numerical improvement was observed Giredestrant plus palbociclib was well tolerated and adverse events were consistent with the known safety profiles of each individual treatment Genentech is committed to transforming ER-positive breast cancer care, anchored by &#8230; <span class=\"more\"><a class=\"more-link\" href=\"https:\/\/pharma-trend.com\/en\/genentech-provides-update-on-phase-iii-persevera-study-in-er-positive-advanced-breast-cancer\/\">[Read more&#8230;]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-62756","6":"format-standard","7":"category-industry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genentech Provides Update on Phase III persevERA Study in ER-positive Advanced Breast Cancer - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/genentech-provides-update-on-phase-iii-persevera-study-in-er-positive-advanced-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genentech Provides Update on Phase III persevERA Study in ER-positive Advanced Breast Cancer - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"persevERA Breast Cancer study did not meet the primary objective of a statistically significant improvement in progression-free survival, but a numerical improvement was observed Giredestrant plus palbociclib was well tolerated and adverse events were consistent with the known safety profiles of each individual treatment Genentech is committed to transforming ER-positive breast cancer care, anchored by ... 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