{"id":62837,"date":"2026-03-24T13:02:26","date_gmt":"2026-03-24T12:02:26","guid":{"rendered":"https:\/\/pharma-trend.com\/en\/alnylam-advances-future-of-attr-cm-care-through-strategic-collaboration-with-viz-ai-and-support-for-the-american-heart-association\/"},"modified":"2026-03-24T13:02:26","modified_gmt":"2026-03-24T12:02:26","slug":"alnylam-advances-future-of-attr-cm-care-through-strategic-collaboration-with-viz-ai-and-support-for-the-american-heart-association","status":"publish","type":"post","link":"https:\/\/pharma-trend.com\/en\/alnylam-advances-future-of-attr-cm-care-through-strategic-collaboration-with-viz-ai-and-support-for-the-american-heart-association\/","title":{"rendered":"Alnylam Advances Future of ATTR-CM Care Through Strategic Collaboration with Viz.ai and Support for the American Heart Association"},"content":{"rendered":"
\n

\n\u2212 Efforts Aimed at Facilitating Earlier Diagnosis, Coordinated Care, and Long-Term Patient Impact in ATTR-CM \u2013<\/i><\/p>\n

\n\u2212 Alnylam to Host TTR Investor Webinar Today at 9:30 am ET \u2013<\/i><\/p>\n

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Alnylam Pharmaceuticals, Inc.<\/a> (Nasdaq: ALNY), the leading RNAi therapeutics company, today announced a set of strategic efforts designed to accelerate earlier recognition and improve care coordination for patients with the cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR-CM). Through complementary initiatives with Viz.ai and the American Heart Association, Alnylam is advancing a comprehensive, system\u2011level approach to address persistent challenges of underdiagnosis and fragmented care in ATTR\u2011CM.<\/p>\n

<\/a>
<\/a><\/p>\n

\nATTR\u2011CM is a rapidly progressive, life\u2011threatening cause of heart failure that remains significantly underrecognized. Early and accurate diagnosis is critical to enabling access to appropriate management and improving outcomes. Despite advances in treatment, many patients remain undiagnosed for years, preventing access to necessary care. Alnylam aims to move ATTR-CM diagnosis upstream, accelerating earlier identification and enabling health systems to deliver consistent, high\u2011quality patient care at scale.<\/p>\n

\n\u201cAs a cardiologist, I\u2019ve seen firsthand the devastating impact of diagnosing ATTR\u2011CM too late,\u201d said Sameer Bansilal, M.D., M.S., Vice President, Global TTR Medical Lead, Alnylam Pharmaceuticals. \u201cThis is a progressive disease where timing truly matters \u2013 earlier recognition can fundamentally change a patient\u2019s course of disease. Alnylam\u2019s leadership in ATTR amyloidosis is grounded not only in deep science, a robust R&D program, and strong clinical evidence, but in a commitment to enduring impact \u2013 improving how this disease is identified and managed in real-world care. By working with leading health systems, technology innovators, and national clinical organizations, Alnylam is dedicated to building the infrastructure needed to diagnose ATTR-CM earlier and deliver more coordinated care.\u201d<\/p>\n

\nStrengthening Detection and Care Coordination for ATTR-CM in Collaboration with Viz.ai<\/b><\/p>\n

\nAlnylam is partnering with Viz.ai, the leader in artificial intelligence (AI)-powered disease detection and care coordination, to develop an AI-enabled ATTR-CM care pathway designed to help clinicians identify patients earlier in the course of disease and guide appropriate diagnostic evaluation and referral. The pathway combines a U.S. Food and Drug Administration (FDA)-cleared echocardiography AI algorithm, Us2.ai, with electronic health record connectivity and integration into routine clinical practice to support earlier recognition of ATTR-CM and facilitate coordinated care across cardiology and heart failure teams.<\/p>\n

\nThe collaboration includes the AI-Enhanced Echocardiography Workflow to Advance Recognition and Diagnosis of Cardiac Amyloidosis (AWARE) study \u2013 one of the first multi-system prospective implementation studies designed to evaluate how AI-enabled screening can be integrated into routine clinical workflows and assess its impact on diagnostic timelines, care coordination, and clinical decision-making in ATTR-CM. While AI technologies hold significant promise for improving disease detection, implementation and adoption within real-world clinical settings remain a key challenge, and the AWARE study is intended to help address this barrier by evaluating practical approaches to integrating AI tools into existing care pathways.<\/p>\n

\nThe initiative will launch at five pilot health systems later this year, representing a diverse set of clinical settings, with the goal of generating real-world evidence to inform broader, scalable adoption across health systems in the Viz.ai network.<\/p>\n

\n\u201cWhen ATTR\u2011CM is identified late, patients face the risk of disease progression and poorer outcomes,\u201d said Tim Showalter, M.D., Chief Medical Officer, Viz.ai. \u201cBy embedding AI\u2011driven detection into everyday clinical workflows and pairing it with coordinated care pathways, this collaboration focuses on closing the gap between the first clinical signal and meaningful clinical action, so more patients are identified and connected to care sooner before irreversible damage has occurred.\u201d<\/p>\n

\nImproving Systems of Care for ATTR-CM by Supporting the American Heart Association<\/b><\/p>\n

\nComplementing AI-enabled diagnostic technology, Alnylam is supporting a national effort focused on strengthening systems of care for people living with ATTR\u2011CM, led by the American Heart Association, an organization devoted to changing the future to a world of healthier lives for all.<\/p>\n

\nThe three-year initiative will convene a 10-site cohort of multidisciplinary health systems in a national learning collaborative designed to identify gaps in care, share best practices, and scale effective models for diagnosing and managing ATTR-CM. Participating centers will evaluate current practice pathways across diagnosis, referral, treatment, and follow-up in order to improve coordinated care and optimize patient outcomes. Insights generated through the program will be disseminated nationally to help improve care delivery and outcomes for patients with ATTR\u2011CM. This work will amplify proven, replicable models of excellence with the goal of enabling a stronger, more integrated system of care for patients nationwide.<\/p>\n

\nAlnylam is a proud supporter of the American Heart Association’s ATTR-CM Discovery Initiative: Improving the System of Care Across the ATTR Patient Journey<\/a>.<\/p>\n

\nShaping the Future of ATTR-CM Care
\n
<\/b>Together, these efforts reflect Alnylam\u2019s leadership in redefining how ATTR\u2011CM is identified and managed, by shifting diagnosis earlier, strengthening care pathways, and enabling more consistent, coordinated care at scale. By investing in AI\u2011enabled detection, real\u2011world evidence, and system\u2011level partnerships, Alnylam aims to address the root causes of underdiagnosis and fragmentation and help ensure that patients are identified at a point when intervention may make the greatest difference.<\/p>\n

\nAlnylam leadership will discuss these initiatives and how the Company is shaping the future of ATTR-CM care in a webinar today at 9:30 am ET. The webinar can be accessed on the Investors section of the Company\u2019s website at www.alnylam.com\/events<\/b><\/a>. An archived webcast will be available on the Alnylam website approximately two hours after the event.<\/p>\n

\nAbout Transthyretin Amyloidosis (ATTR)
\n
<\/b>Transthyretin amyloidosis (ATTR) is an underdiagnosed, rapidly progressive, debilitating and fatal disease caused by misfolded transthyretin (TTR) proteins, which accumulate as amyloid deposits in various parts of the body, including the nerves, heart, and gastrointestinal tract. Patients may present with polyneuropathy, cardiomyopathy, or both manifestations of disease. There are two different forms of ATTR \u2013 hereditary ATTR (hATTR), which is caused by a TTR gene variant, and wild-type ATTR (wtATTR), which occurs without a TTR gene variant. It is estimated that 350,000 people worldwide live with ATTR, although ~80% remain undiagnosed.<\/p>\n

\nAbout RNAi
\n
<\/b>RNAi (RNA interference) is a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today. Its discovery has been heralded as \u201ca major scientific breakthrough that happens once every decade or so,\u201d and was recognized with the award of the 2006 Nobel Prize for Physiology or Medicine. By harnessing the natural biological process of RNAi occurring in our cells, a new class of medicines known as RNAi therapeutics is now a reality. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam\u2019s RNAi therapeutic platform, function upstream of today\u2019s medicines by potently silencing messenger RNA (mRNA) \u2013 the genetic precursors \u2013 that encode for disease-causing or disease pathway proteins, thus preventing them from being made. <\/sup>This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases.<\/p>\n

\nAbout Alnylam Pharmaceuticals
\n
<\/b>Alnylam (Nasdaq: ALNY) is a leading global biopharmaceutical company and the pioneer of the RNA interference (RNAi) revolution. The Company is focused on developing transformative therapies with the potential to prevent, halt, or reverse disease. For more than two decades, Alnylam has advanced the Nobel-Prize-winning science of RNAi, delivering critical breakthroughs and six approved medicines. Alnylam has medicines available in more than 70 countries and a rapidly expanding and robust pipeline, in addition to consistently being recognized as an exceptional workplace and socially responsible organization. The Company is executing on its Alnylam 2030<\/i> strategy to accelerate innovation and scale impact to transform human health. For more information, please visit www.alnylam.com<\/a> or follow Alnylam on X<\/a>, LinkedIn<\/a>, Facebook<\/a>, Instagram<\/a>, or YouTube<\/a>.<\/p>\n

\nAlnylam Forward-Looking Statements
\n
<\/b>This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. All statements other than historical statements of fact regarding Alnylam\u2019s expectations, beliefs, goals, plans or prospects including, without limitation, statements regarding: Alnylam\u2019s ability to advance the future care of ATTR-CM, including through its efforts to facilitate earlier recognition and diagnosis of ATTR-CM, to improve the quality, consistency and coordination of care for ATTR-CM patients, and to optimize patient outcomes and enable long-term patient impact in ATTR-CM; the potential success of Alnylam\u2019s initiatives with Viz.ai and the American Heart Association; and Alnylam\u2019s ability to execute on its Alnylam 2030 <\/i>strategy to accelerate innovation and scale to transform human health, should be considered forward-looking statements. Actual results and future plans may differ materially from those indicated by these forward-looking statements as a result of various important risks, uncertainties and other factors, including, without limitation, risks and uncertainties relating to Alnylam\u2019s ability to successfully execute on its Alnylam 2030<\/i> strategy; Alnylam\u2019s ability to discover and develop novel drug candidates and delivery approaches and successfully demonstrate the efficacy and safety of its product candidates; the pre-clinical and clinical results for Alnylam\u2019s product candidates; the possibility of unfavorable new clinical data and further analyses of existing clinical data; interim and preliminary data; the possibility that clinical data are subject to differing interpretations and assessments by regulatory agencies; actions or advice of regulatory agencies and Alnylam\u2019s ability to obtain and maintain regulatory approval for its product candidates, as well as favorable pricing and reimbursement; successfully launching, marketing and selling Alnylam\u2019s approved products globally; delays, interruptions or failures in the manufacture and supply of Alnylam\u2019s product candidates or its marketed products; obtaining, maintaining and protecting intellectual property; Alnylam\u2019s ability to manage its growth and operating expenses through disciplined investment in operations; Alnylam\u2019s ability to maintain strategic business collaborations; Alnylam\u2019s dependence on third parties for the development and commercialization of certain products; the outcome of litigation; the potential risk of future government investigations; and unexpected expenditures; as well as those risks more fully discussed in the \u201cRisk Factors\u201d filed with Alnylam\u2019s 2025 Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC), as may be updated from time to time in Alnylam\u2019s subsequent Quarterly Reports on Form 10-Q, and in other filings that Alnylam makes with the SEC. In addition, any forward-looking statements represent Alnylam\u2019s views only as of today and should not be relied upon as representing Alnylam\u2019s views as of any subsequent date. Alnylam explicitly disclaims any obligation, except to the extent required by law, to update any forward-looking statements.<\/p>\n

Contacts<\/b> <\/p>\n

\nAlnylam Pharmaceuticals, Inc.<\/b><\/p>\n

\nChristine Akinc
\n
(Investors and Media)
\n
+1-617-682-4340<\/p>\n

\nJosh Brodsky
\n
(Investors)
\n
+1-617-551-8276<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u2212 Efforts Aimed at Facilitating Earlier Diagnosis, Coordinated Care, and Long-Term Patient Impact in ATTR-CM \u2013 \u2212 Alnylam to Host TTR Investor Webinar Today at 9:30 am ET \u2013 CAMBRIDGE, Mass.–(BUSINESS WIRE)–Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, today announced a set of strategic efforts designed to accelerate earlier recognition and improve … [Read more…]<\/a><\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":{"0":"entry","1":"post","2":"publish","3":"author-business","4":"post-62837","6":"format-standard","7":"category-industry"},"yoast_head":"\nAlnylam Advances Future of ATTR-CM Care Through Strategic Collaboration with Viz.ai and Support for the American Heart Association - Pharma Trend<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pharma-trend.com\/en\/alnylam-advances-future-of-attr-cm-care-through-strategic-collaboration-with-viz-ai-and-support-for-the-american-heart-association\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alnylam Advances Future of ATTR-CM Care Through Strategic Collaboration with Viz.ai and Support for the American Heart Association - Pharma Trend\" \/>\n<meta property=\"og:description\" content=\"\u2212 Efforts Aimed at Facilitating Earlier Diagnosis, Coordinated Care, and Long-Term Patient Impact in ATTR-CM \u2013 \u2212 Alnylam to Host TTR Investor Webinar Today at 9:30 am ET \u2013 CAMBRIDGE, Mass.–(BUSINESS WIRE)–Alnylam Pharmaceuticals, Inc. 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(Nasdaq: ALNY), the leading RNAi therapeutics company, today announced a set of strategic efforts designed to accelerate earlier recognition and improve ... 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