DUBLIN–(BUSINESS WIRE)–The “LYNPARZA Market Drug Insight and Market Forecast – 2032” report has been added to ResearchAndMarkets.com’s offering.
“LYNPARZA Market Drug Insight and Market Forecast – 2032” report provides comprehensive insights about LYNPARZA for Pancreatic Cancer in the seven major markets. A detailed picture of the LYNPARZA for pancreatic cancer in the 7MM, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan for the study period 2019 -2032 is provided in this report along with a detailed description of the LYNPARZA for pancreatic cancer.
The report provides insights about mechanism of action, dosage and administration, as well as research and development including regulatory milestones, along with other developmental activities. Further, it also consists of future market assessments inclusive of the LYNPARZA market forecast analysis for pancreatic cancer in the 7MM, SWOT, analysts’ views, comprehensive overview of market competitors, and brief about other emerging therapies in pancreatic cancer.
Drug Summary
LYNPARZA (olaparib) is a first-in-class PARP inhibitor and the first targeted treatment to block DNA damage response (DDR) in cells/tumors harboring a deficiency in homologous recombination repair, such as mutations in BRCA1 and/or BRCA2. Inhibition of PARP with LYNPARZA leads to the trapping of PARP bound to DNA single-strand breaks, stalling of replication forks, their collapse, and the generation of DNA double-strand breaks and cancer cell death. In the DDR pathways, LYNPARZA is being tested in a range of PARP-dependent tumor types with defects and dependencies.
LYNPRAZA is indicated for the maintenance treatment of adult patients with deleterious or suspected deleterious gBRCAm metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen.
Dosage and Administration
A dose of 300 mg should be taken orally twice a day with or without food.
Mechanism of Action
Olaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, including PARP1, PARP2, and PARP3. Normal cellular functions are performed by PARP enzymes, such as DNA transcription and DNA repair. Olaparib has been shown to inhibit the growth of select tumor cell lines in vitro and decrease tumor growth in mouse xenograft models of human cancer, both as monotherapy or following platinum-based chemotherapy.
Increased cytotoxicity and antitumor activity following treatment with olaparib were noted in cell lines and mouse tumor models with deficiencies in BRCA1/2, ATM, or other genes involved in the homologous recombination repair (HRR) of DNA damage and correlated with platinum response. In vitro studies have shown that olaparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes, resulting in DNA damage and cancer cell death.
Scope of the Report
The report provides insights into:
- A comprehensive product overview including the LYNPARZA description, mechanism of action, dosage and administration, research and development activities in pancreatic cancer.
- Elaborated details on LYNPARZA regulatory milestones and other development activities have been provided in this report.
- The report also highlights the LYNPARZA research and development activities in pancreatic cancer across the United States, Europe and Japan.
- The report also covers the patents information with expiry timeline around LYNPARZA.
- The report contains forecasted sales of for pancreatic cancer till 2032.
- Comprehensive coverage of the late-stage emerging therapies for pancreatic cancer.
- The report also features the SWOT analysis with analyst views for LYNPARZA in pancreatic cancer.
Methodology
The report is built using data and information sourced primarily from internal databases, primary and secondary research and in-house analysis by the research team of industry experts. Information and data from the secondary sources have been obtained from various printable and nonprintable sources like search engines, news websites, global regulatory authorities websites, trade journals, white papers, magazines, books, trade associations, industry associations, industry portals and access to available databases.
LYNPARZA Analytical Perspective
In-depth LYNPARZA Market Assessment
This report provides a detailed market assessment of LYNPARZA for pancreatic cancer in the seven major markets, i.e., the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. This segment of the report provides forecasted sales data from 2023 to 2032.
LYNPARZA Clinical Assessment
The report provides the clinical trials information of LYNPARZA for pancreatic cancer covering trial interventions, trial conditions, trial status, start and completion dates.
Report Highlights
- In the coming years, the market scenario for pancreatic cancer is set to change due to the extensive research and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
The companies are developing therapies that focus on novel approaches to treat/improve the disease condition, assess challenges, and seek opportunities that could influence LYNPARZA dominance.
- Other emerging products for pancreatic cancer are expected to give tough market competition to LYNPARZA and launch of late-stage emerging therapies in the near future will significantly impact the market.
- A detailed description of regulatory milestones, and developmental activities, provide the current development scenario of LYNPARZA in pancreatic cancer.
- The in-depth analysis of the forecasted sales data of LYNPARZA from 2023 to 2032 will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the LYNPARZA in pancreatic cancer.
Key Questions Answered
- What is the product type, route of administration and mechanism of action of LYNPARZA?
- What is the clinical trial status of the study related to LYNPARZA in pancreatic cancer and study completion date?
- What are the key collaborations, mergers and acquisitions, licensing and other activities related to the LYNPARZA development?
- What are the key designations that have been granted to LYNPARZA for pancreatic cancer?
- What is the forecasted market scenario of LYNPARZA for pancreatic cancer?
- What are the forecasted sales of LYNPARZA in the seven major countries, including the United States, Europe (Germany, France, Italy, Spain, and the United Kingdom), and Japan?
- What are the other emerging products available and how are these giving competition to LYNPARZA for pancreatic cancer?
- Which are the late-stage emerging therapies under development for the treatment of pancreatic cancer?
For more information about this report visit https://www.researchandmarkets.com/r/o2a38i-market?w=4
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