New identities advance a modern approach to evidence generation
DURHAM, N.C.–(BUSINESS WIRE)–Target RWE and NoviSci, two leaders in evidence generation, today announced they will rebrand as Pedestal Health and Headwater Science. These two distinct companies will work to build a modern evidence-generation engine for life sciences organizations, navigating the most complex and consequential research challenges.
Pedestal Health (formerly Target RWE) is a full-service evidence generation partner for life sciences organizations. The company delivers scientifically rigorous, regulatory-ready longitudinal datasets that serve a variety of evidence generation needs, from traditional real-world evidence to externally controlled trials to prospective clinical studies. Currently in liver disease, dermatology, and gastroenterology, Pedestal Health’s evidence generation capabilities deliver regulatory-grade insights, with a focus on translating complex data into decisions that improve patient care.
Headwater Science (formerly NoviSci) is a methodological and analytical engine for real-world data. With deep expertise in causal inference, comparative effectiveness, healthcare utilization and expenditure, and regulatory-grade software, Headwater Science brings principled, reproducible, and innovative data science to the most complex scientific questions in medicine. Alan Brookhart, a leader in the development and application of methods for real-world evidence, recently returned to lead Headwater Science into this new phase.
Together, the two companies form the core of Highlander Health’s vision to reduce treatment access time by 50% through continuous evidence generation and more personalized care, modernizing episodic, start-from-scratch studies with an infrastructure that compounds over time. The companies were the inaugural investment of Highlander Health, a firm co-founded by industry veterans Amy Abernethy, M.D., Ph.D., and Brad Hirsch, M.D. to advance evidence generation and personalized healthcare for the new era of medical innovation.
“The evidence system underpinning drug development has been operating on an outdated model: studies run in isolation, programs that reset with each question and insights that arrive too late to shape time-sensitive decisions. Pedestal Health and Headwater Science are built around a different premise: that evidence should be continuous, cumulative and designed from the start to inform care,” said Amy Abernethy, co-CEO of Pedestal Health and Headwater Science.
Co-CEO of Pedestal Health and Headwater Science, Brad Hirsch added: “Amy and I founded Highlander Health to solve some of the biggest challenges facing healthcare. The rebrands represent more than a name change. They reflect a shared conviction: that the evidence system powering today’s drug development was not built for what modern science demands.”
The rebrands will be formally introduced at the ISPOR Annual Meeting, May 17-20 in Philadelphia, where leaders from both companies will engage with industry stakeholders and share more about their combined vision and capabilities. You can also visit the team in person at booth 1111.
About Pedestal Health
Pedestal Health (formerly Target RWE) combines deep health system partnerships, longitudinal data curation at scale, and modern study design to build continuous, high-quality evidence for life sciences organizations. The company partners with pharmaceutical and biotech companies, providers and payers to generate rigorous, multimodal evidence that supports clinical, regulatory and strategic decision-making across the full lifecycle of care. Pedestal Health is committed to advancing medical decision-making to improve outcomes for patients. Pedestal Health is a Highlander Health company. Learn more at pedestalhealth.com.
About Headwater Science
Headwater Science (formerly NoviSci) is a data science and methods company specializing in principled, reproducible evidence generation for complex clinical and regulatory challenges. With deep expertise in comparative effectiveness, causal inference, healthcare utilization and expenditure research, and regulatory-grade analytical software, Headwater Science provides the methodological foundation that delivers reproducible analytic pipelines, novel epidemiologic and statistical methods, and regulatory-grade software validated to hold up under the most demanding scrutiny. The company works with life sciences organizations as a long-term scientific partner. Headwater Science is a Highlander Health company. Learn more at headwaterscience.com.
About Highlander Health
Highlander Health is focused on advancing evidence generation for the new era of medical innovation. Through an investment portfolio and a platform for learning across care settings, Highlander Health is on a mission to modernize clinical research and care — toward flexible approaches, unlocked capacity, and faster and greater patient impact. Learn more and join in our work to move evidence generation forward at highlanderhealth.com.
Contacts
Media Contact for Headwater Science and Pedestal Health:
Nicole Contardo
720-838-8416
ncontardo@pedestalhealth.com
Media Contact for Highlander Health:
Rachel Ford Hutman
Rachel@fordhutmanmedia.com


